Major heart defects: the diagnostic evaluations of first-year-olds
Jazyk angličtina Země Velká Británie, Anglie Médium electronic
Typ dokumentu časopisecké články
PubMed
34847867
PubMed Central
PMC8630885
DOI
10.1186/s12887-021-02997-2
PII: 10.1186/s12887-021-02997-2
Knihovny.cz E-zdroje
- Klíčová slova
- Congenital heart defect, Cyanosis, Murmur, Symptom,
- MeSH
- cyanóza etiologie MeSH
- defekty komorového septa * MeSH
- dítě MeSH
- kohortové studie MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- retrospektivní studie MeSH
- těhotenství MeSH
- vrozené srdeční vady * diagnóza MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Severe or critical congenital heart defects (CHDs) constitute one third of the heart defect cases detected only after birth. These prenatally unrecognised defects usually manifest as cyanotic or acyanotic lesions and are diagnosed postnatally at various times. The aim of the study was to identify their clinical symptoms and determine individual risk periods for CHD manifestation. METHODS: Data were assessed retrospectively based on a cohort of patients born between 2009 and 2018 in a population of 175,153 live births. Occurrence of the first symptoms of CHD was classified into: early neonatal (0-7 days), late neonatal (8-28 days), early infancy (1-6 months), or late infancy (6-12 months). The first symptom for which the child was referred to a paediatric cardiologist was defined as a symptom of CHD. RESULTS: There were 598 major CHDs diagnosed in the studied region, 91% of which were isolated anomalies. A concomitant genetic disorder was diagnosed in 6% of the cases, while 3% presented extracardiac pathology with a normal karyotype. In total, 47% (282/598) of all CHDs were not identified prenatally. Of these, 74% (210/282) were diagnosed as early neonates, 16% (44/282) as late neonates, and 10% (28/282) as infants. The most common symptoms leading to the diagnosis of CHD were heart murmur (51%, 145/282) and cyanosis (26%, 73/282). Diagnosis after discharge from the hospital occurred in 12% (72/598) of all major CHDs. Ventricular septal defect and coarctation of the aorta constituted the majority of delayed diagnoses. CONCLUSIONS: In conclusion, murmur and cyanosis are the most common manifestations of prenatally undetected CHDs. Although most children with major CHDs are diagnosed as neonates, some patients are still discharged from the maternity hospital with an unidentified defect.
Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
Department of Obstetrics and Gynaecology University Hospital Ostrava Ostrava Czech Republic
Department of Pediatrics Palacky University Hospital Palacky University Olomouc Czech Republic
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