The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

Bioinformatics Research Laboratory Department of Biological Sciences University of Cyprus Nicosia Cyprus

Bioinformatics Unit Fundación Instituto Leloir Buenos Aires C1405BWE Argentina

Biological Computation and Computational Biology Group Artificial Intelligence and Information Analysis Lab Department of Computer Science Aristotle University of Thessalonica Thessalonica 54124 Greece

Biological Computation and Process Laboratory Chemical Process and Energy Resources Institute Centre for Research and Technology Hellas Thermi Thessalonica 57001 Greece

Cancer Structural Biology Danish Cancer Society Research Center Strandboulevarden 49 2100 Copenhagen Denmark

Cancer Systems Biology Section for Bioinformatics Department of Health and Technology Technical University of Denmark Lyngby Denmark

Cytocast Kft Vecsés Hungary

Dep of Cell Biology Faculty of Science Vinicna 7 128 43 Prague Czech Republic

Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona Barcelona Spain

Departamento de Ciencia y Tecnología Universidad Nacional de Quilmes CONICET Bernal Buenos Aires B1876BXD Argentina

Department of Biochemistry Eötvös Loránd University Pázmány Péter stny 1 c Budapest H 1117 Hungary

Department of Biomedical Sciences University of Padova Padova Italy

Department of Cell Biology Faculty of Science Charles University BIOCEV Prague Czech Republic

Department of Woman and Child Health University of Padova Padova Italy

European Molecular Biology Laboratory European Bioinformatics Institute Wellcome Genome Campus Hinxton UK

Faculty of Information Technology and Bionics Pázmány Péter Catholic University Práter u 50 A 1083 Budapest Hungary

ICREA Barcelona Spain

Institut de Biotecnologia i Biomedicina Universitat Autònoma de Barcelona Barcelona Spain

Institute for Genome Sciences University of Maryland School of Medicine 670 W Baltimore St Baltimore MD 21201 USA

Institute of Biomembranes Bioenergetics and Molecular Biotechnologies National Research Council Bari Italy

Institute of Cancer Research Chester Beatty Laboratories 237 Fulham Rd Chelsea London UK

Institute of Enzymology Research Centre for Natural Sciences Budapest 1117 Hungary

Instituto de Biologia Molecular e Celular Universidade do Porto 4200 135 Porto Portugal

Instituto de Investigação e Inovação em Saúde Universidade do Porto 4200 135 Porto Portugal

Instituto de Investigaciones Biotecnológicas Universidad Nacional de San Martín Av 25 de Mayo y Francia CP1650 Buenos Aires Argentina

Lab Architecture et Fonction des Macromolécules Biologiques 163 Avenue de Luminy Case 932 13288 Marseille France

Laboratory for Bioinformatics and Computational Chemistry Vinča Institute of Nuclear Sciences National Institute of the Republic of Serbia University of Belgrade 11000Belgrade Serbia

Pediatric Research Institute Città della Speranza Padova Italy

Science for Life Laboratory Department of Biochemistry and Biophysics Stockholm University 171 21 Solna Sweden

Structural and Computational Biology Unit European Molecular Biology Laboratory Heidelberg 69117 Germany

Structural Biology Brussels Brussels Belgium

Swiss Prot group SIB Swiss Institute of Bioinformatics Geneva Switzerland

VIB VUB Center for Structural Biology Vlaams Instituut voor Biotechnology Brussels Belgium

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