Enantioselective Construction of Chiral Bispiro[Oxindole-Pyrrolidine-Pyrazolone] Derivatives via Sequential and One-Pot Mannich/Hydroamination Reaction
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Catalysis MeSH
- Molecular Structure MeSH
- Oxindoles MeSH
- Pyrazolones * MeSH
- Pyrrolidines MeSH
- Stereoisomerism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Oxindoles MeSH
- Pyrazolones * MeSH
- Pyrrolidines MeSH
The atom-economic method for the preparation of novel bispirocyclic compounds containing three fused heterocyclic scaffolds privileged in drug discovery was developed by using a chiral amine-squaramide Mannich reaction and Au(I)-catalyzed hydroamination. The developed synthetic strategy performed either stepwise or as a one-pot process allows the formation of chiral bispirocyclic [oxindole-pyrrolidine-pyrazolones] in high yields (up to 75%) with excellent enantioselectivities (up to 99%).
Department of Inorganic Chemistry Charles University Hlavova 8 12843 Prague Czech Republic
Department of Organic Chemistry Charles University Hlavova 8 12843 Prague Czech Republic
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