The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.

Addenbrooke's Hospital Cambridge UK

Amazon Web Services Inc Seattle WA USA

Arizona State University Washington DC USA

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Barcelona Supercomputing Center Barcelona Spain

Barcelonaβeta Brain Research Center Pasqual Maragall Foundation Barcelona Spain

BBMRI ERIC Graz Austria

Bicgen Foundation Inc Arlington Heights IL USA

Brigham and Women's Hospital Boston MA USA

Broad Institute of MIT and Harvard Cambridge MA USA

California Institute of Technology Pasadena CA USA

Canada's Michael Smith Genome Sciences Centre BC Cancer Vancouver BC Canada

Canadian Center for Computational Genomics Montreal QC Canada

Canadian Centre for Computational Genomics Montreal QC Canada

Canadian Distributed Infrastructure for Genomics Toronto ON Canada

Centre for Genomic Regulation The Barcelona Institute of Science and Technology Barcelona Spain

Cincinnati Children's Hospital Medical Center Cincinnati OH USA

CNAG CRG Centre for Genomic Regulation The Barcelona Institute of Science and Technology Barcelona Spain

Congenica Ltd Cambridge UK

CSC IT Center for Science Espoo Finland

Datadex Inc Toronto ON Canada

DNAstack Toronto ON Canada

Duke Margolis Center for Health Policy Washington DC USA

École polytechnique fédérale de Lausanne Lausanne Switzerland

ELIXIR Finland Espoo Finland

ELIXIR Hub Hinxton UK

European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK

European Molecular Biology Laboratory Heidelberg Germany

Faculty of Medicine University Southampton Southampton UK

Garvan Institute of Medical Research Darlinghurst NSW Australia

Genome Institute of Singapore Singapore Republic of Singapore

Genomic Medicine Institute Geisinger Danville PA USA

Genomics England London UK

Global Alliance for Genomics and Health Toronto ON Canada

Google LLC Kitchener ON Canada

H3ABioNet Computational Biology Division IDM Faculty of Health Sciences Cape Town South Africa

Harvard Medical School Boston MA USA

Health Data Research UK London UK

Heidelberg Academy of Sciences and Humanities Heidelberg Germany

Howard Hughes Medical Institute University of California Santa Cruz CA USA

Human Genetics Society of Australasia Education Ethics and Social Issues Committee Alexandria NSW Australia

Indoc Research Toronto ON Canada

Institució Catalana de Recerca i Estudis Avançats Barcelona Spain

Institute of Evolutionary Biology Barcelona Spain

Invitae San Francisco CA USA

Japan Agency for Medical Research and Development Tokyo Japan

Johns Hopkins University Baltimore MD USA

Keio University School of Medicine Tokyo Japan

Kelly Government Solutions Rockville MD USA

Laura Paglione LLC New York NY USA

Masaryk University Brno Czech Republic

Massachusetts General Brigham Boston MA USA

Mayo Clinic Rochester MN USA

McGill University Montreal QC Canada

Melbourne Law School University of Melbourne Parkville VIC Australia

Memorial Sloan Kettering Cancer Center New York NY USA

mlin net LLC San Jose CA USA

Murdoch Children's Research Institute Parkville VIC Australia

MyOme Inc San Bruno CA USA

National Cancer Institute National Institutes of Health Bethesda MD USA

National Center for Biotechnology Information National Library of Medicine National Institutes of Health Bethesda MD USA

National Center for Global Health and Medicine Hospital Tokyo Japan

National Center for Global Health and Medicine Tokyo Japan

National Heart Lung and Blood Institute National Institutes of Health Bethesda MD USA

National Human Genome Research Institute National Institutes of Health Bethesda MD USA

National Taiwan University Taipei City Taiwan

Nationwide Children's Hospital Columbus OH USA

Ontario Institute for Cancer Research Toronto ON Canada

Oregon Health and Science University Portland OR USA

Osaka University Suita Japan

Patient Centered Outcomes Research Institute Washington DC USA

PhenoTips Toronto ON Canada

Precision Health Research Singapore Singapore Republic of Singapore

Pryzm Health Sydney QLD Australia

QIMR Berghofer Medical Research Institute Herston QLD Australia

Queen Mary University of London London UK

RIKEN Center for Integrative Medical Sciences Yokohama Japan

Sage Bionetworks Seattle WA USA

Salt Lake City UT USA

Section of Translational Medical Ethics University Hospital Heidelberg Heidelberg Germany

Seven Bridges Boston MA USA

SIB Swiss Institute of Bioinformatics Lausanne Switzerland

Sidra Medicine Doha Qatar

SingHealth Duke NUS Genomic Medicine Centre Singapore Republic of Singapore

SingHealth Duke NUS Institute of Precision Medicine Singapore Republic of Singapore

Spherical Cow Group New York NY USA

Stanford University Stanford CA USA

The Australian e Health Research Centre CSIRO Herston QLD Australia

The Jackson Laboratory Farmington CT USA

The Ohio State University Columbus OH USA

The University of Hong Kong Hong Kong Hong Kong

Tohoku University Sendai Japan

UC Santa Cruz Genomics Institute Santa Cruz CA USA

Universitat de Barcelona Barcelona Spain

Universitat Pompeu Fabra Barcelona Spain

University Health Network Toronto ON Canada

University of Basel Basel Switzerland

University of Cambridge Cambridge UK

University of Chicago Chicago IL USA

University of Colorado Anschutz Medical Campus Aurora CO USA

University of Connecticut Farmington CT USA

University of Edinburgh Edinburgh UK

University of Glasgow Glasgow UK

University of Lausanne Lausanne Switzerland

University of Leicester Leicester UK

University of Luxembourg Esch sur Alzette Luxembourg

University of Melbourne Melbourne VIC Australia

University of Michigan Ann Arbor MI USA

University of Northampton Northampton UK

University of Nottingham Nottingham UK

University of Oxford Oxford UK

University of Tokyo Tokyo Japan

University of Toronto Toronto ON Canada

University of Utah Salt Lake City UT USA

University of Virginia Charlottesville VA USA

University of Waterloo Waterloo ON Canada

University of Zurich Zurich Switzerland

Vanderbilt University Medical Center Nashville TN USA

Vector Institute Toronto ON Canada

Verily Life Sciences South San Francisco CA USA

Walter and Eliza Hall Institute of Medical Research Parkville VIC Australia

Washington University School of Medicine in St Louis St Louis MO USA

Weill Cornell Medicine Qatar Doha Qatar

Wellcome Connecting Science Hinxton UK

Wellcome Sanger Institute Hinxton UK

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Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies

Recording provenance of workflow runs with RO-Crate

A corpus of GA4GH Phenopackets: case-level phenotyping for genomic diagnostics and discovery

GA4GH Passport standard for digital identity and access permissions

The Data Use Ontology to streamline responsible access to human biomedical datasets