We report the difunctional modification of an anionic cobalta bis(dicarbollide)(1-) cluster with a B(8,8')-oxygen bridging unit that provides structural rigidity and an organic alkylazide substituent(s) on the carbon atoms of the metallacarborane cage. These ions present a good binding motif for incorporation into organic molecules using Huisgen-Sharpless (2+3) cycloaddition reactions. In addition, the compounds are chiral, as verified by separation of enantiomers using HPLC on chiral stationary phases (CSPs) and provide a high electrochemical peak in the window located outside of typical signals of biomolecules.

Dpt of Inorganic and General Chemistry Faculty of Chemical Technology University of Pardubice Studentská 95 532 10 Pardubice Czech Republic

Faculty of Pharmacy Charles University Akademika Heyrovskeho 1203 500 05 Hradec Kráové Czech Republic

Institute of Biophysics Czech Academy of Sciences Královopolská 135 612 65 Brno Czech Republic

Institute of Inorganic Chemistry Czech Academy of Sciences 25068 Řež Czech Republic

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