Involvement of calcium signaling in different types of cell death in cancer
Language English Country Slovakia Media print-electronic
Document type Journal Article, Review
PubMed
35144473
DOI
10.4149/neo_2022_220127n121
PII: 220127N121
Knihovny.cz E-resources
- MeSH
- Apoptosis MeSH
- Autophagy MeSH
- Cell Death MeSH
- Ferroptosis * MeSH
- Humans MeSH
- Neoplasms * pathology MeSH
- Necroptosis MeSH
- Calcium Signaling MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Programmed cell death is a basic feature of chemotherapeutic (and also radiotherapeutic) intervention. Induction of cell death in tumor cells aims to kill preferentially the tumor cells, with minimal impact on the normal cells. Although apoptosis is the most obvious type of cell death induced by chemotherapeutics, several other types can also be activated, especially in conditions, where cells are resistant to apoptosis induction. Calcium signaling was shown to play an indisputable role in the activation of different types of cell death. Local increase of the calcium in time and precise place of this increase is secured by calcium transport systems. In this review, we summarized the involvement of some calcium transport systems in apoptosis, autophagy, necroptosis, ferroptosis, and mitophagy during cancer development and treatment.
References provided by Crossref.org
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Miro proteins and their role in mitochondrial transfer in cancer and beyond