Assessment and Treatment of Negative Symptoms in Schizophrenia-A Regional Perspective
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic-ecollection
Typ dokumentu časopisecké články, přehledy
PubMed
35185643
PubMed Central
PMC8855151
DOI
10.3389/fpsyt.2021.820801
Knihovny.cz E-zdroje
- Klíčová slova
- Central and Eastern Europe, assessment, negative symptoms, personality, review, schizophrenia, treatment,
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Clinicians and researchers consider that there are a variety of symptoms that constitute negative symptoms in schizophrenia, and they may use different definitions for the same symptoms. These differences are also reflected in a variety of negative symptom rating scales. Both research and clinical work are negatively affected by the lack of consensus regarding the symptoms that constitute negative symptoms in schizophrenia. Leading research groups have investigated ways to reduce heterogeneity in the domain of negative symptoms in schizophrenia; however, little attention has been paid to regional differences in the concepts of negative symptoms in schizophrenia. The objective of this review was to collect and summarize information about the assessment and treatment of negative symptoms of schizophrenia in Central and Eastern Europe (CEE). Nineteen experts from 17 countries in CEE participated in this project. The participants collected information about their countries, including the following: (1) the most important publications about negative symptoms in schizophrenia (irrespective of the time of their publication); (2) the most frequently used negative symptom of schizophrenia in clinical practice; (3) definitions of frequently used negative symptoms; and (4) treatment of negative symptoms in schizophrenia. The participating experts/countries most frequently reported the following five negative symptoms: avolition, blunted affect, alogia, asociality, and anhedonia. Several experts also considered other symptoms as belonging to the negative symptom domain, such as a decrease in energy level and changes in personality. The importance of evaluating the long-term course and the relationship between negative symptoms and other symptom domains was also noted. No noticeable differences were reported in the treatment of negative symptoms compared to currently published guidelines and algorithms. The most frequently reported negative symptoms included those defined by the NIMH-MATRICS consensus statement on negative symptoms and recently endorsed in a guidance paper of the European Psychiatric Association. The main differences in the concepts, names, and definitions of primary negative symptoms, especially those related to personality changes, and to the evaluation of the long-term course and relationship between different symptom domains in CEE compared to the current English language literature deserve the attention of psychiatrists and other professionals in this field.
3rd Faculty of Medicine Charles University Prague Prague Czechia
Clinical Center National Institute of Mental Health Klecany Czechia
Clinical Hospital Centre Zagreb and School of Medicine University of Zagreb Zagreb Croatia
Department for Therapy of Mental Disorders Moscow Research Institute of Psychiatry Moscow Russia
Department of Psychiatry and Medical Psychology Belarusian State Medical University Minsk Belarus
Department of Psychiatry and Medical Psychology Tbilisi State University Tbilisi Georgia
Department of Psychiatry and Narcology Riga Stradins University Riga Latvia
Department of Psychiatry and Psychotherapy Medical School University of Pécs Pécs Hungary
Department of Psychiatry and Psychotherapy Semmelweis University Budapest Hungary
Department of Psychiatry Lithuanian University of Health Sciences Kaunas Lithuania
Department of Psychiatry Medical University of Warsaw Warsaw Poland
Department of Psychiatry Pomeranian Medical University in Szczecin Szczecin Poland
Department of Psychiatry Russian Medical Academy of Continuous Professional Education Moscow Russia
Faculty of Medicine University of Belgrade and Institute of Mental Health Belgrade Serbia
Psychiatric Clinic University Hospital Alexandrovska Sofia Bulgaria
Zobrazit více v PubMed
Bitter I. Definitions and measurement of negative symptoms in schizophrenia. In: Bitter I, editor. Managing Negative Symptoms of Schizophrenia. Oxford: Oxford University Press; (2020). p. 1–18. 10.1093/med/9780198840121.003.0001 DOI
Galderisi S, Mucci A, Dollfus S, Nordentoft M, Falkai P, Kaiser S, et al. . EPA guidance on assessment of negative symptoms in schizophrenia. Eur Psychiatry. (2021) 64:e23. 10.1192/j.eurpsy.2021.11 PubMed DOI PMC
Galderisi S, Kaiser S, Bitter I, Nordentoft M, Mucci A, Sabé M, et al. . EPA guidance on treatment of negative symptoms in schizophrenia. Eur Psychiatry. (2021) 64:e21. 10.1192/j.eurpsy.2021.13 PubMed DOI PMC
Kirkpatrick B, Fenton WS, Carpenter WT, Marder SR. The NIMH-MATRICS consensus statement on negative symptoms. Schizophr Bull. (2006) 32:214–9. 10.1093/schbul/sbj053 PubMed DOI PMC
Su CC, Chia-Cheng Lai E, Kao Yang YH, Man KKC, Kubota K, Stang P, et al. . Incidence, prevalence and prescription patterns of antipsychotic medications use in Asia and US: a cross-nation comparison with common data model. J Psychiatr Res. (2020) 131:77–84. 10.1016/j.jpsychires.2020.08.025 PubMed DOI
Bitter I, Treuer T, Dyachkova Y, Martenyi F, McBride M, Ungvari GS. Antipsychotic prescription patterns in outpatient settings: 24-month results from the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study. Eur Neuropsychopharmacol. (2008) 18:170–80. 10.1016/j.euroneuro.2007.08.001 PubMed DOI
Ng CH, Kato T, Han C, Wang G, Trivedi M, Ramesh V, et al. . Definition of treatment-resistant depression - Asia Pacific perspectives. J Affect Disord. (2019) 245:626–36. 10.1016/j.jad.2018.11.038 PubMed DOI
Winkler P, Krupchanka D, Roberts T, Kondratova L, Machu V, Höschl C, et al. . A blind spot on the global mental health map: a scoping review of 25 years' development of mental health care for people with severe mental illnesses in central and eastern Europe. Lancet Psychiatry. (2017) 4:634–42. 10.1016/S2215-0366(17)30135-9 PubMed DOI
Szkultecka-Debek M, Walczak J, Augustyńska J, Miernik K, Stelmachowski J, Pieniazek I, et al. . Epidemiology and treatment guidelines of negative symptoms in schizophrenia in Central and Eastern Europe: a literature review. Clin Pract Epidemiol Ment Health. (2015) 11:158–65. 10.2174/1745017901511010158 PubMed DOI PMC
Furedi J, Mohr P, Swingler D, Bitter I, Gheorghe MD, Hotujac L, et al. . Psychiatry in selected countries of Central and Eastern Europe: an overview of the current situation. Acta Psychiatr Scand. (2006) 114:223–31. 10.1111/j.1600-0447.2006.00804.x PubMed DOI
Szkultecka-Debek M, Miernik K, Stelmachowski J, Jakovljević M, Jukić V, Aadamsoo K, et al. . Schizophrenia causes significant burden to patients' and caregivers' lives. Psychiatr Danub. (2016) 28:104–10 PubMed
Kentchadze V, Okribelashvili N, Naneishvili G. History of psychiatry in georgia: hidden pages (dedicated to our teachers). Georgian Med News. (2017) 265:130–8. PubMed
Huber, Huber G, Huber G. Defektsyndrome und basisstadien endogener psychosen. Fortsch Neurol Psychiatr. (1966) 34:409–4015.
Ebel H, Gross G, Klosterkötter J, Huber G. Basic symptoms in schizophrenic and affective psychoses. Psychopathology. (1989) 22:224–32. 10.1159/000284602 PubMed DOI
Mosolov SN, Yaltonskaya PA. Primary and secondary negative symptoms in schizophrenia. Front Psychiatry. (2021) 12:766692. 10.3389/fpsyt.2021.766692 PubMed DOI PMC
Mosolov SN, Yaltonskaya PA. Concept, classification and clinical differentiation of negative symptoms inschizophrenia. Sovrem Psih Rasstrojstv. (2020) 1:2–14. 10.21265/PSYPH.2020.15.30.001 PubMed DOI
Raspopova NI, Bastasova UA, Eshimbetova SZ. Negative Disorders in the Clinical Picture of Schizophrenia. Study Guide. Almaty: Lambert Academic Publishing; (2021). p. 60.
Smulevich A, Romanov D. Long-term course of negative symptoms in schizophrenia. In: Bitter I, editor. Managing Negative Symptoms of Schizophrenia. Oxford: Oxford University Press; (2020). p. 39–50. 10.1093/med/9780198840121.003.0003 DOI
Capatina OO, Miclutia IV. Are negative symptoms in schizophrenia a distinct therapeutic target? Clujul Med. (2018) 91:58–64. 10.15386/cjmed-864 PubMed DOI PMC
Capaţina OO, Miclutia I. Course of negative symptoms sudomanins in schizophrenia: a one year follow-up study. In: 26th European Congress of Psychiatry. Issy-les-Moulineaux: European Psychiatry (2018). p. S348-S. PW0859. 10.26226/morressier.5a7070e5d462b80290b571f4 DOI
Neznanov N, Martynikhin I, Mosolov S. Diagnosis of schizophrenia in Russia: the results of a web-based survey of psychiatrists. Sovrem Psih Rasstrojstv. (2019) 1:2–13. 10.21265/PSYPH.2019.24.24.001 DOI
Capatina OO, Miclutia IV, Fadgyas-Stanculete M. Current perspectives in treating negative symptoms of schizophrenia: a narrative review (Review). Exp Ther Med. (2021) 21:276. 10.3892/etm.2021.9707 PubMed DOI PMC
Masopust J, Mohr P, Kopeček M. Antipsychotics in treatment of predominant negative symptoms in schizophrenia: an update of guidelines. Psychiatrie. (2020) 24:40–3.
Mosolov SN, Yaltonskaya PA. An algorithm for the treatment of primary negative symptoms in schizophrenia. Sovrem Psih Rasstrojstv. (2020) 2:2–10. 10.21265/PSYPH.2020.26.17.001 DOI
Cerveri G, Gesi C, Mencacci C. Pharmacological treatment of negative symptoms in schizophrenia: update and proposal of a clinical algorithm. Neuropsychiatr Dis Treat. (2019) 15:1525–35. 10.2147/NDT.S201726 PubMed DOI PMC
Czobor P, Bitter I. Pharmacologic treatment of negative symptoms: focus on efficacy. In: Bitter I, editor. Managing Negative Symptoms of Schizophrenia. Oxford: Oxford University Press; (2020). p. 67–86. 10.1093/med/9780198840121.003.0005 DOI
Novak T, Horacek J, Mohr P, Kopecek M, Skrdlantova L, Klirova M, et al. . The double-blind sham-controlled study of high-frequency rTMS (20 Hz) for negative symptoms in schizophrenia: negative results. Neuro Endocrinol Lett. (2006) 27:209–13. PubMed
Prikryl R, Kasparek T, Skotakova S, Ustohal L, Kucerova H, Ceskova E. Treatment of negative symptoms of schizophrenia using repetitive transcranial magnetic stimulation in a double-blind, randomized controlled study. Schizophr Res. (2007) 95:151–7. 10.1016/j.schres.2007.06.019 PubMed DOI
Prikryl R, Ustohal L, Prikrylova Kucerova H, Kasparek T, Venclikova S, Vrzalova M, et al. . A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: a double-blind trial. Schizophr Res. (2013) 149:167–73. 10.1016/j.schres.2013.06.015 PubMed DOI
Maslenikov NV, Mosolov SN, Smirnov NA, Tsukarzi EE. Repetitive transcranial magnetic stimulation (rTMS) effects on depression, negative symptoms and cognition in schizophrenia. Brain Stimul. (2015) 8:333 10.1016/j.brs.2015.01.078 DOI
Fuchs T, Broschmann D. [Disorders of the will in psychopathology]. Nervenarzt. (2017) 88:1252–8. 10.1007/s00115-017-0323-1 PubMed DOI
Strauss GP, Zamani Esfahlani F, Sayama H, Kirkpatrick B, Opler MG, Saoud JB, et al. . Network analysis indicates that avolition is the most central domain for the successful treatment of negative symptoms: evidence from the roluperidone randomized clinical trial. Schizophr Bull. (2020) 46:964–70. 10.1093/schbul/sbz141 PubMed DOI PMC
Gard DE, Kring AM, Gard MG, Horan WP, Green MF. Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure. Schizophr Res. (2007) 93:253–60. 10.1016/j.schres.2007.03.008 PubMed DOI PMC
Erkwoh R, Herpertz S, Sass H. [Personality disorders and schizophrenic psychoses]. Nervenarzt. (2003) 74:740–7. 10.1007/s00115-003-1474-9 PubMed DOI
World Health Organization . International Statistical Classification of Diseases and Related Health Problems. 11th ed. (2019). Avaialble online at: https://icd.who.int/ (accessed November 20, 2021).
Kirkpatrick B, Cohen A, Bitter I, Strauss GP. Primary negative symptoms: refining the research target. Schizophr Bull. (2021) 47:1207–10. 10.1093/schbul/sbab069 PubMed DOI PMC
Krause M, Zhu Y, Huhn M, Schneider-Thoma J, Bighelli I, Nikolakopoulou A, et al. . Antipsychotic drugs for patients with schizophrenia and predominant or prominent negative symptoms: a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci. (2018) 268:625–39. 10.1007/s00406-018-0869-3 PubMed DOI