Since Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) was introduced as a new thyroid tumour entity, many studies, and meta-analyses on diagnosing NIFTP have been published. NIFTP-revised histopathological criteria emerged in 2018. NIFTP is defined as a histological entity and its diagnosis requires a careful histological examination. Its molecular profile is similar to follicular-like tumours. Ultrasound features are unable to differentiate NIFTP. NIFTP is not a cytological diagnosis, but it influences the risk of malignancy in several categories of The Bethesda System for Reporting Thyroid Cytopathology terminology.

Department of Biology Faculty of Medicine in Pilsen Charles University 32300 Pilsen Czech Republic

Department of Imaging Methods University Hospital Pilsen Faculty of Medicine in Pilsen Charles University Alej Svobody 80 30460 Pilsen Czech Republic

Department of Otorhinolaryngology and Head and Neck Surgery 1st Faculty of Medicine University Hospital Motol Charles University 15006 Prague Czech Republic

Faculty of Medicine and Health Technology Tampere University Arvo Ylpön Katu 34 33520 Tampere Finland

Pathology Fimlab Laboratories Arvo Ylpön Katu 4 33520 Tampere Finland

Zobrazit více v PubMed

Tallini G., Tuttle R.M., Ghossein R.A. The History of the Follicular Variant of Papillary Thyroid Carcinoma. J. Clin. Endocrinol. Metab. 2017;102:15–22. doi: 10.1210/jc.2016-2976. PubMed DOI

Lindsay S. Natural history of thyroid carcinoma. Ariz. Med. 1960;17:623–627. PubMed

Chem K.T., Rosai J. Follicular variant of thyroid papillary carcinoma: A clinicopathologic study of six cases. Am. J. Surg. Pathol. 1977;1:123–130. doi: 10.1097/00000478-197706000-00003. PubMed DOI

Williams E.D. Guest Editorial: Two Proposals Regarding the Terminology of Thyroid Tumors. Int. J. Surg. Pathol. 2000;8:181–183. doi: 10.1177/106689690000800304. PubMed DOI

Nikiforov Y.E., Seethala R.R., Tallini G., Baloch Z.W., Basolo F., Thompson L.D., Barletta J.A., Wenig B.M., Al Ghuzlan A., Kakudo K., et al. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors. JAMA Oncol. 2016;2:1023–1029. doi: 10.1001/jamaoncol.2016.0386. PubMed DOI PMC

Lloyd R.V., Osamura R.Y., Klöppel G., Rosai J. WHO Classification of Tumours of Endocrine Organs. International Agency for Research on Cancer; Lyon, France: 2017.

Haugen B.R., Sawka A.M., Alexander E.K., Bible K.C., Caturegli P., Doherty G.M., Mandel S.J., Morris J.C., Nassar A., Pacini F., et al. American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features. Thyroid. 2017;27:481–483. doi: 10.1089/thy.2016.0628. PubMed DOI

Hodak S., Tuttle R.M., Maytal G., Nikiforov Y.E., Randolph G. Changing the Cancer Diagnosis: The Case of Follicular Variant of Papillary Thyroid Cancer-Primum Non Nocere and NIFTP. Thyroid. 2016;26:869–871. doi: 10.1089/thy.2016.0205. PubMed DOI

Parente D.N., Kluijfhout W.P., Bongers P.J., Verzijl R., Devon K.M., Rotstein L.E., Goldstein D.P., Asa S.L., Mete O., Pasternak J.D. Clinical Safety of Renaming Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: Is NIFTP Truly Benign? World J. Surg. 2018;42:321–326. doi: 10.1007/s00268-017-4182-5. PubMed DOI

Kim T.H., Lee M., Kwon A.Y., Choe J.H., Kim J.H., Kim J.S., Hahn S.Y., Shin J.H., Chung M.K., Son Y.I., et al. Molecular genotyping of the non-invasive encapsulated follicular variant of papillary thyroid carcinoma. Histopathology. 2018;72:648–661. doi: 10.1111/his.13401. PubMed DOI

Cho U., Mete O., Kim M.H., Bae J.S., Jung C.K. Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: The impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features. Mod. Pathol. 2017;30:810–825. doi: 10.1038/modpathol.2017.9. PubMed DOI

Nikiforov Y.E., Baloch Z.W., Hodak S.P., Giordano T.J., Lloyd R.V., Seethala R.R., Wenig B.M. Change in Diagnostic Criteria for Noninvasive Follicular Thyroid Neoplasm With Papillarylike Nuclear Features. JAMA Oncol. 2018;4:1125–1126. doi: 10.1001/jamaoncol.2018.1446. PubMed DOI PMC

Alves V.A.F., Kakudo K., LiVolsi V., Lloyd R.V., Nikiforov Y.E., Nose V., Papotti M., Thompson L.D.R. Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTP): Achieving Better Agreement By Refining Diagnostic Criteria. Clinics. 2018;73:e576. doi: 10.6061/clinics/2018/e576. PubMed DOI PMC

LiVolsi V.A., Baloch Z. Noninvasive Follicular Tumor with Papillary-like Nuclear Features: A Practice Changer in Thyroid Pathology. Arch. Pathol. Lab. Med. 2021;145:659–663. doi: 10.5858/arpa.2019-0689-RA. PubMed DOI

Seethala R.R., Baloch Z.W., Barletta J.A., Khanafshar E., Mete O., Sadow P.M., LiVolsi V.A., Nikiforov Y.E., Tallini G., Thompson L.D. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A review for pathologists. Mod. Pathol. 2018;31:39–55. doi: 10.1038/modpathol.2017.130. PubMed DOI

Fakhar Y., Khooei A., Aghaee A., Mohammadzadeh Kosari H., Wartofsky L., Zakavi S.R. Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report. BMC Endocr. Disord. 2021;21:221. doi: 10.1186/s12902-021-00883-7. PubMed DOI PMC

Rosario P.W., Mourao G.F. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A review for clinicians. Endocr.-Relat. Cancer. 2019;26:R259–R266. doi: 10.1530/ERC-19-0048. PubMed DOI

Rana C., Vuong H.G., Nguyen T.Q., Nguyen H.C., Jung C.K., Kakudo K., Bychkov A. The Incidence of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Meta-Analysis Assessing Worldwide Impact of the Reclassification. Thyroid. 2021;31:1502–1513. doi: 10.1089/thy.2021.0158. PubMed DOI

Liu Z., Bychkov A., Jung C.K., Hirokawa M., Sui S., Hong S., Lai C.R., Jain D., Canberk S., Kakudo K. Interobserver and intraobserver variation in the morphological evaluation of noninvasive follicular thyroid neoplasm with papillary-like nuclear features in Asian practice. Pathol. Int. 2019;69:202–210. doi: 10.1111/pin.12779. PubMed DOI

Lloyd R.V., Erickson L.A., Casey M.B., Lam K.Y., Lohse C.M., Asa S.L., Chan J.K., DeLellis R.A., Harach H.R., Kakudo K., et al. Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma. Am. J. Surg. Pathol. 2004;28:1336–1340. doi: 10.1097/01.pas.0000135519.34847.f6. PubMed DOI

Elsheikh T.M., Asa S.L., Chan J.K., DeLellis R.A., Heffess C.S., LiVolsi V.A., Wenig B.M. Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma. Am. J. Clin. Pathol. 2008;130:736–744. doi: 10.1309/AJCPKP2QUVN4RCCP. PubMed DOI

Jung C.K., Bychkov A., Song D.E., Kim J.H., Zhu Y., Liu Z., Keelawat S., Lai C.R., Hirokawa M., Kameyama K., et al. Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms. Endocrinol. Metab. 2021;36:123–133. doi: 10.3803/EnM.2020.860. PubMed DOI PMC

Bychkov A., Jung C.K., Liu Z., Kakudo K. Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Asian Practice: Perspectives for Surgical Pathology and Cytopathology. Endocr. Pathol. 2018;29:276–288. doi: 10.1007/s12022-018-9519-6. PubMed DOI PMC

Ruanpeng D., Cheungpasitporn W., Thongprayoon C., Hennessey J.V., Shrestha R.T. Systematic Review and Meta-analysis of the Impact of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on Cytological Diagnosis and Thyroid Cancer Prevalence. Endocr. Pathol. 2019;30:189–200. doi: 10.1007/s12022-019-09583-4. PubMed DOI

Cancer Genome Atlas Research N. Integrated genomic characterization of papillary thyroid carcinoma. Cell. 2014;159:676–690. doi: 10.1016/j.cell.2014.09.050. PubMed DOI PMC

Song Y.S., Park Y.J. Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E. Endocrinol. Metab. 2020;35:515–525. doi: 10.3803/EnM.2020.304. PubMed DOI PMC

Lee S.E., Hwang T.S., Choi Y.L., Kim W.Y., Han H.S., Lim S.D., Kim W.S., Yoo Y.B., Kim S.K. Molecular Profiling of Papillary Thyroid Carcinoma in Korea with a High Prevalence of BRAF(V600E) Mutation. Thyroid. 2017;27:802–810. doi: 10.1089/thy.2016.0547. PubMed DOI

Brandler T.C., Zhou F., Liu C.Z., Cho M., Lau R.P., Simsir A., Patel K.N., Sun W. Can noninvasive follicular thyroid neoplasm with papillary-like nuclear features be distinguished from classic papillary thyroid carcinoma and follicular adenomas by fine-needle aspiration? Cancer Cytopathol. 2017;125:378–388. doi: 10.1002/cncy.21848. PubMed DOI

Strickland K.C., Eszlinger M., Paschke R., Angell T.E., Alexander E.K., Marqusee E., Nehs M.A., Jo V.Y., Lowe A., Vivero M., et al. Molecular Testing of Nodules with a Suspicious or Malignant Cytologic Diagnosis in the Setting of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Endocr. Pathol. 2018;29:68–74. doi: 10.1007/s12022-018-9515-x. PubMed DOI

Zhao L., Dias-Santagata D., Sadow P.M., Faquin W.C. Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma. Cancer Cytopathol. 2017;125:323–331. doi: 10.1002/cncy.21839. PubMed DOI

Paulson V.A., Shivdasani P., Angell T.E., Cibas E.S., Krane J.F., Lindeman N.I., Alexander E.K., Barletta J.A. Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Accounts for More Than Half of “Carcinomas” Harboring RAS Mutations. Thyroid. 2017;27:506–511. doi: 10.1089/thy.2016.0583. PubMed DOI

Pusztaszeri M., Bongiovanni M. The impact of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the diagnosis of thyroid nodules. Gland Surg. 2019;8:S86–S97. doi: 10.21037/gs.2018.12.01. PubMed DOI PMC

Pool C., Walter V., Bann D., Goldenberg D., Broach J., Hennessy M., Cottrill E., Washburn E., Williams N., Crist H., et al. Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) Virchows Arch. 2019;474:341–351. doi: 10.1007/s00428-018-02512-6. PubMed DOI

Zajkowska K., Kopczynski J., Gozdz S., Kowalska A. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A problematic entity. Endocr. Connect. 2020;9:R47–R58. doi: 10.1530/EC-19-0566. PubMed DOI PMC

Brandler T.C., Yee J., Zhou F., Cho M., Cangiarella J., Wei X.J., Yee-Chang M., Sun W. Does noninvasive follicular thyroid neoplasm with papillary-like nuclear features have distinctive features on sonography? Diagn. Cytopathol. 2018;46:139–147. doi: 10.1002/dc.23863. PubMed DOI

Afkhami M., Karunamurthy A., Chiosea S., Nikiforova M.N., Seethala R., Nikiforov Y.E., Coyne C. Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAF(K601E) Mutation. Thyroid. 2016;26:242–247. doi: 10.1089/thy.2015.0227. PubMed DOI

Johnson D.N., Furtado L.V., Long B.C., Zhen C.J., Wurst M., Mujacic I., Kadri S., Segal J.P., Antic T., Cipriani N.A. Noninvasive Follicular Thyroid Neoplasms with Papillary-like Nuclear Features Are Genetically and Biologically Similar to Adenomatous Nodules and Distinct From Papillary Thyroid Carcinomas with Extensive Follicular Growth. Arch. Pathol. Lab. Med. 2018;142:838–850. doi: 10.5858/arpa.2017-0118-OA. PubMed DOI

Geramizadeh B., Maleki Z. Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): A review and update. Endocrine. 2019;64:433–440. doi: 10.1007/s12020-019-01887-z. PubMed DOI

Kim M.J., Won J.K., Jung K.C., Kim J.H., Cho S.W., Park D.J., Park Y.J. Clinical Characteristics of Subtypes of Follicular Variant Papillary Thyroid Carcinoma. Thyroid. 2018;28:311–318. doi: 10.1089/thy.2016.0671. PubMed DOI

Song Y.S., Won J.K., Yoo S.K., Jung K.C., Kim M.J., Kim S.J., Cho S.W., Lee K.E., Yi K.H., Seo J.S., et al. Comprehensive Transcriptomic and Genomic Profiling of Subtypes of Follicular Variant of Papillary Thyroid Carcinoma. Thyroid. 2018;28:1468–1478. doi: 10.1089/thy.2018.0198. PubMed DOI

Melo M., da Rocha A.G., Vinagre J., Batista R., Peixoto J., Tavares C., Celestino R., Almeida A., Salgado C., Eloy C., et al. TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas. J. Clin. Endocrinol. Metab. 2014;99:E754–E765. doi: 10.1210/jc.2013-3734. PubMed DOI PMC

Kuchareczko A., Kopczynski J., Kowalik A., Hincza K., Plusa A., Gozdz S., Kowalska A. Are molecular tests necessary to diagnose NIFTP? Genes Cancer. 2021;12:39–50. doi: 10.18632/genesandcancer.213. PubMed DOI PMC

Sohn S.Y., Lee J.J., Lee J.H. Molecular Profile and Clinicopathologic Features of Follicular Variant Papillary Thyroid Carcinoma. Pathol. Oncol. Res. 2020;26:927–936. doi: 10.1007/s12253-019-00639-8. PubMed DOI

Amendoeira I., Maia T., Sobrinho-Simoes M. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Impact on the reclassification of thyroid nodules. Endocr.-Relat. Cancer. 2018;25:R247–R258. doi: 10.1530/ERC-17-0513. PubMed DOI

Paniza A.C.J., Mendes T.B., Viana M.D.B., Thomaz D.M.D., Chiappini P.B.O., Colozza-Gama G.A., Lindsey S.C., de Carvalho M.B., Alves V.A.F., Curioni O., et al. Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior. Endocr. Connect. 2019;8:1529–1538. doi: 10.1530/EC-19-0459. PubMed DOI PMC

Jahanbani I., Al-Abdallah A., Ali R.H., Al-Brahim N., Mojiminiyi O. Discriminatory miRNAs for the Management of Papillary Thyroid Carcinoma and Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features. Thyroid. 2018;28:319–327. doi: 10.1089/thy.2017.0127. PubMed DOI

Park J.L., Kim S.K., Jeon S., Jung C.K., Kim Y.S. MicroRNA Profile for Diagnostic and Prognostic Biomarkers in Thyroid Cancer. Cancers. 2021;13:632. doi: 10.3390/cancers13040632. PubMed DOI PMC

Borrelli N., Denaro M., Ugolini C., Poma A.M., Miccoli M., Vitti P., Miccoli P., Basolo F. miRNA expression profiling of ‘noninvasive follicular thyroid neoplasms with papillary-like nuclear features’ compared with adenomas and infiltrative follicular variants of papillary thyroid carcinomas. Mod. Pathol. 2017;30:39–51. doi: 10.1038/modpathol.2016.157. PubMed DOI

Kalfert D., Ludvikova M., Pesta M., Ludvik J., Dostalova L., Kholova I. Multifunctional Roles of miR-34a in Cancer: A Review with the Emphasis on Head and Neck Squamous Cell Carcinoma and Thyroid Cancer with Clinical Implications. Diagnostics. 2020;10:563. doi: 10.3390/diagnostics10080563. PubMed DOI PMC

Ludvikova M., Kalfert D., Kholova I. Pathobiology of MicroRNAs and Their Emerging Role in Thyroid Fine-Needle Aspiration. Acta Cytol. 2015;59:435–444. doi: 10.1159/000442145. PubMed DOI

Mahmoudian-Sani M.R., Jalali A., Jamshidi M., Moridi H., Alghasi A., Shojaeian A., Mobini G.R. Long Non-Coding RNAs in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, and Therapy. Oncol. Res. Treat. 2019;42:136–142. doi: 10.1159/000495151. PubMed DOI

Kwon M.R., Shin J.H., Hahn S.Y., Oh Y.L., Kwak J.Y., Lee E., Lim Y. Histogram analysis of greyscale sonograms to differentiate between the subtypes of follicular variant of papillary thyroid cancer. Clin. Radiol. 2018;73:591.e1–591.e7. doi: 10.1016/j.crad.2017.12.008. PubMed DOI

Yang G.C.H., Fried K.O. Pathologic basis of the sonographic differences between thyroid cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Ultrasonography. 2018;37:157–163. doi: 10.14366/usg.17045. PubMed DOI PMC

Hoang J.K., Middleton W.D., Farjat A.E., Langer J.E., Reading C.C., Teefey S.A., Abinanti N., Boschini F.J., Bronner A.J., Dahiya N., et al. Reduction in Thyroid Nodule Biopsies and Improved Accuracy with American College of Radiology Thyroid Imaging Reporting and Data System. Radiology. 2018;287:185–193. doi: 10.1148/radiol.2018172572. PubMed DOI

Watkins L., O’Neill G., Young D., McArthur C. Comparison of British Thyroid Association, American College of Radiology TIRADS and Artificial Intelligence TIRADS with histological correlation: Diagnostic performance for predicting thyroid malignancy and unnecessary fine needle aspiration rate. Br. J. Radiol. 2021;94:20201444. doi: 10.1259/bjr.20201444. PubMed DOI PMC

Tessler F.N., Middleton W.D., Grant E.G. Thyroid Imaging Reporting and Data System (TI-RADS): A User’s Guide. Radiology. 2018;287:29–36. doi: 10.1148/radiol.2017171240. PubMed DOI

Tessler F.N., Middleton W.D., Grant E.G., Hoang J.K., Berland L.L., Teefey S.A., Cronan J.J., Beland M.D., Desser T.S., Frates M.C., et al. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee. J. Am. Coll. Radiol. 2017;14:587–595. doi: 10.1016/j.jacr.2017.01.046. PubMed DOI

Shin J.H., Baek J.H., Chung J., Ha E.J., Kim J.H., Lee Y.H., Lim H.K., Moon W.J., Na D.G., Park J.S., et al. Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations. Korean J. Radiol. 2016;17:370–395. doi: 10.3348/kjr.2016.17.3.370. PubMed DOI PMC

Lauria Pantano A., Maddaloni E., Briganti S.I., Beretta Anguissola G., Perrella E., Taffon C., Palermo A., Pozzilli P., Manfrini S., Crescenzi A. Differences between ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications performance in identifying cytological high-risk thyroid nodules. Eur. J. Endocrinol. 2018;178:595–603. doi: 10.1530/EJE-18-0083. PubMed DOI

Middleton W.D., Teefey S.A., Reading C.C., Langer J.E., Beland M.D., Szabunio M.M., Desser T.S. Comparison of Performance Characteristics of American College of Radiology TI-RADS, Korean Society of Thyroid Radiology TIRADS, and American Thyroid Association Guidelines. AJR Am. J. Roentgenol. 2018;210:1148–1154. doi: 10.2214/AJR.17.18822. PubMed DOI

Kwon H., Jeon M.J., Yoon J.H., Hong S.J., Lee J.H., Kim T.Y., Shong Y.K., Kim W.B., Kim W.G., Song D.E. Preoperative clinicopathological characteristics of patients with solitary encapsulated follicular variants of papillary thyroid carcinomas. J. Surg. Oncol. 2017;116:746–755. doi: 10.1002/jso.24700. PubMed DOI

Yang G.C.H., Fried K.O., Scognamiglio T. Sonographic and cytologic differences of NIFTP from infiltrative or invasive encapsulated follicular variant of papillary thyroid carcinoma: A Review of 179 Cases. Diagn. Cytopathol. 2017;45:533–541. doi: 10.1002/dc.23709. PubMed DOI

Yang G.C.H., Fried K.O., Scognamiglio T. Can cytology and the Thyroid Imaging, Reporting, and Data System (TI-RADS) identify noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) before surgery? J. Am. Soc. Cytopathol. 2020;9:159–165. doi: 10.1016/j.jasc.2020.01.002. PubMed DOI

Hahn S.Y., Shin J.H., Lim H.K., Jung S.L., Oh Y.L., Choi I.H., Jung C.K. Preoperative differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and non-NIFTP. Clin. Endocrinol. 2017;86:444–450. doi: 10.1111/cen.13263. PubMed DOI

Lee H.S., Lee J.W., Park J.H., Kim W.S., Han H.S., Lee S.E. Comprehensive analysis for diagnosis of preoperative non-invasive follicular thyroid neoplasm with papillary-like nuclear features. PLoS ONE. 2019;14:e0218046. doi: 10.1371/journal.pone.0218046. PubMed DOI PMC

Hahn S.Y., Shin J.H., Oh Y.L., Kim T.H., Lim Y., Choi J.S. Role of Ultrasound in Predicting Tumor Invasiveness in Follicular Variant of Papillary Thyroid Carcinoma. Thyroid. 2017;27:1177–1184. doi: 10.1089/thy.2016.0677. PubMed DOI

Boursier L., Clerc Urmes I., Garon J., Klein M., Demarquet L. Ultrasound and cytological characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features compared to papillary carcinomas. Ann. Endocrinol. 2020;81:28–33. doi: 10.1016/j.ando.2019.10.004. PubMed DOI

Rosario P.W. Is Doppler ultrasonography of value for the differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroid carcinoma? Clin. Endocrinol. 2018;88:506–507. doi: 10.1111/cen.13523. PubMed DOI

You S.H., Lee K.E., Yoo R.E., Choi H.J., Jung K.C., Won J.K., Kang K.M., Yoon T.J., Choi S.H., Sohn C.H., et al. Prevention of total thyroidectomy in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) based on combined interpretation of ultrasonographic and cytopathologic results. Clin. Endocrinol. 2018;88:114–122. doi: 10.1111/cen.13473. PubMed DOI

Figge J.J., Gooding W.E., Steward D.L., Yip L., Sippel R.S., Yang S.P., Scheri R.P., Sipos J.A., Mandel S.J., Mayson S.E., et al. Do Ultrasound Patterns and Clinical Parameters Inform the Probability of Thyroid Cancer Predicted by Molecular Testing in Nodules with Indeterminate Cytology? Thyroid. 2021;31:1673–1682. doi: 10.1089/thy.2021.0119. PubMed DOI PMC

Trimboli P., Castellana M., Virili C., Havre R.F., Bini F., Marinozzi F., D’Ambrosio F., Giorgino F., Giovanella L., Prosch H., et al. Performance of contrast-enhanced ultrasound (CEUS) in assessing thyroid nodules: A systematic review and meta-analysis using histological standard of reference. Radiol. Med. 2020;125:406–415. doi: 10.1007/s11547-019-01129-2. PubMed DOI

Zhao C.K., Xu H.X. Ultrasound elastography of the thyroid: Principles and current status. Ultrasonography. 2019;38:106–124. doi: 10.14366/usg.18037. PubMed DOI PMC

Garino F., Deandrea M., Motta M., Mormile A., Ragazzoni F., Palestini N., Freddi M., Gasparri G., Sgotto E., Pacchioni D., et al. Diagnostic performance of elastography in cytologically indeterminate thyroid nodules. Endocrine. 2015;49:175–183. doi: 10.1007/s12020-014-0438-0. PubMed DOI

Stoian D., Borcan F., Petre I., Mozos I., Varcus F., Ivan V., Cioca A., Apostol A., Dehelean C.A. Strain Elastography as a Valuable Diagnosis Tool in Intermediate Cytology (Bethesda III) Thyroid Nodules. Diagnostics. 2019;9:119. doi: 10.3390/diagnostics9030119. PubMed DOI PMC

Borlea A., Stoian D., Cotoi L., Sporea I., Lazar F., Mozos I. Thyroid Multimodal Ultrasound Evaluation—Impact on Presurgical Diagnosis of Intermediate Cytology Cases. Appl. Sci. 2020;10:3439. doi: 10.3390/app10103439. DOI

Mahajan S., Agarwal S., Kocheri N., Jain D., Mathur S.R., Iyer V.K. Cytopathology of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: A comparative study with similar patterned papillary thyroid carcinoma variants. Cytopathology. 2018;29:233–240. doi: 10.1111/cyt.12537. PubMed DOI

Maletta F., Massa F., Torregrossa L., Duregon E., Casadei G.P., Basolo F., Tallini G., Volante M., Nikiforov Y.E., Papotti M. Cytological features of “noninvasive follicular thyroid neoplasm with papillary-like nuclear features” and their correlation with tumor histology. Hum. Pathol. 2016;54:134–142. doi: 10.1016/j.humpath.2016.03.014. PubMed DOI

Chandler J.B., Colunga M., Prasad M.L., Callender G.G., Quinn C., Chhieng D., Adeniran A.J. Identification of distinct cytomorphologic features in the diagnosis of NIFTP at the time of preoperative FNA: Implications for patient management. Cancer Cytopathol. 2017;125:865–875. doi: 10.1002/cncy.21910. PubMed DOI

Diaz Del Arco C., Fernandez Acenero M.J. Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Can Cytology Face the Challenge of Diagnosis in the Light of the New Classification? Acta Cytol. 2018;62:265–272. doi: 10.1159/000488579. PubMed DOI

Hirokawa M., Higuchi M., Suzuki A., Hayashi T., Kuma S., Miyauchi A. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A single-institutional experience in Japan. Endocr. J. 2017;64:1149–1155. doi: 10.1507/endocrj.EJ17-0214. PubMed DOI

Hirokawa M., Higuchi M., Suzuki A., Hayashi T., Kuma S., Miyauchi A. Prevalence and diagnostic significance of noninvasive follicular thyroid neoplasm with papillary-like nuclear features among tumors previously diagnosed as follicular adenoma: A single-institutional study in Japan. Endocr. J. 2020;67:1071–1075. doi: 10.1507/endocrj.EJ20-0198. PubMed DOI

Howitt B.E., Chang S., Eszlinger M., Paschke R., Drage M.G., Krane J.F., Barletta J.A. Fine-needle aspiration diagnoses of noninvasive follicular variant of papillary thyroid carcinoma. Am. J. Clin. Pathol. 2015;144:850–857. doi: 10.1309/AJCPEIE12POICULI. PubMed DOI

Jaconi M., Manzoni M., Pincelli A.I., Giardini V., Scardilli M., Smith A., Fellegara G., Pagni F. The impact of the non-invasive follicular thyroid neoplasm with papillary-like nuclear feature terminology in the routine diagnosis of thyroid tumours. Cytopathology. 2017;28:495–502. doi: 10.1111/cyt.12459. PubMed DOI

Koshikawa T., Fujita N., Ueda N., Ota Y., Sasaki E., Murakami Y., Hosoda W., Yatabe Y., Hanai N., Higuchi M., et al. Important cytological findings for distinction between follicular variant and conventional papillary thyroid carcinoma, including noninvasive follicular thyroid tumors with papillary-like nuclear features. Endocr. J. 2019;66:475–483. doi: 10.1507/endocrj.EJ18-0525. PubMed DOI

Legesse T., Parker L., Heath J., Staats P.N. Distinguishing non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) from classic and invasive follicular-variant papillary thyroid carcinomas based on cytologic features. J. Am. Soc. Cytopathol. 2019;8:11–17. doi: 10.1016/j.jasc.2018.07.004. PubMed DOI

Maleki S., Zandvakili A., Gera S., Khutti S.D., Gersten A., Khader S.N. Differentiating Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features from Classic Papillary Thyroid Carcinoma: Analysis of Cytomorphologic Descriptions Using a Novel Machine-Learning Approach. J. Pathol. Inform. 2019;10:29. doi: 10.4103/jpi.jpi_25_19. PubMed DOI PMC

Selvaggi S.M. The presence of multinucleated giant cells: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features vs the follicular variant of papillary thyroid carcinoma. Diagn. Cytopathol. 2019;47:1007–1010. doi: 10.1002/dc.24259. PubMed DOI

Strickland K.C., Howitt B.E., Marqusee E., Alexander E.K., Cibas E.S., Krane J.F., Barletta J.A. The Impact of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma on Rates of Malignancy for Fine-Needle Aspiration Diagnostic Categories. Thyroid. 2015;25:987–992. doi: 10.1089/thy.2014.0612. PubMed DOI

Strickland K.C., Vivero M., Jo V.Y., Lowe A.C., Hollowell M., Qian X., Wieczorek T.J., French C.A., Teot L.A., Sadow P.M., et al. Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis. Thyroid. 2016;26:1466–1471. doi: 10.1089/thy.2016.0280. PubMed DOI

Yan L., Sethi S., Park J.W. Cytologic and clinical features of NIFTP: Can we diagnose based on preoperative fine-needle aspiration. Diagn. Cytopathol. 2019;47:1259–1266. doi: 10.1002/dc.24309. PubMed DOI

Zhang Z., Chhieng D., Harshan M., Zheng X., Zakowski M. Cytological features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) J. Am. Soc. Cytopathol. 2019;8:5–10. doi: 10.1016/j.jasc.2018.07.007. PubMed DOI

Bizzarro T., Martini M., Capodimonti S., Straccia P., Lombardi C.P., Pontecorvi A., Larocca L.M., Rossi E.D. Young investigator challenge: The morphologic analysis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on liquid-based cytology: Some insights into their identification. Cancer Cytopathol. 2016;124:699–710. doi: 10.1002/cncy.21777. PubMed DOI

Haaga E., Kalfert D., Ludvikova M., Kholova I. Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Is Not a Cytological Diagnosis, but It Influences Cytological Diagnosis Outcomes: A Systematic Review and Meta-Analysis. Acta Cytol. 2021:1–21. doi: 10.1159/000519757. PubMed DOI PMC

Ali S.Z., Cibas E.S. The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria and Explanatory Notes. 1st ed. Springer; New York, NY, USA: 2010.

Ali S.Z., Cibas E.S. The Bethesda System for Reporting Thyroid Cytopathology. 2nd ed. Springer; Cham, Switzerland: 2018.

Bongiovanni M., Giovanella L., Romanelli F., Trimboli P. Cytological Diagnoses Associated with Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features According to the Bethesda System for Reporting Thyroid Cytopathology: A Systematic Review and Meta-Analysis. Thyroid. 2019;29:222–228. doi: 10.1089/thy.2018.0394. PubMed DOI

Faquin W.C., Wong L.Q., Afrogheh A.H., Ali S.Z., Bishop J.A., Bongiovanni M., Pusztaszeri M.P., VandenBussche C.J., Gourmaud J., Vaickus L.J., et al. Impact of reclassifying noninvasive follicular variant of papillary thyroid carcinoma on the risk of malignancy in The Bethesda System for Reporting Thyroid Cytopathology. Cancer Cytopathol. 2016;124:181–187. doi: 10.1002/cncy.21631. PubMed DOI

Shrestha R.T., Ruanpeng D., Hennessey J.V. Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing. Med. Sci. 2019;7:15. doi: 10.3390/medsci7020015. PubMed DOI PMC

Baloch Z.W., Seethala R.R., Faquin W.C., Papotti M.G., Basolo F., Fadda G., Randolph G.W., Hodak S.P., Nikiforov Y.E., Mandel S.J. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A changing paradigm in thyroid surgical pathology and implications for thyroid cytopathology. Cancer Cytopathol. 2016;124:616–620. doi: 10.1002/cncy.21744. PubMed DOI

Lau R.P., Paulsen J.D., Brandler T.C., Liu C.Z., Simsir A., Zhou F. Impact of the Reclassification of “Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma” to “Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features” on the Bethesda System for Reporting Thyroid Cytopathology: A Large Academic Institution’s Experience. Am. J. Clin. Pathol. 2017;149:50–54. doi: 10.1093/ajcp/aqx136. PubMed DOI

Layfield L.J., Baloch Z.W., Esebua M., Kannuswamy R., Schmidt R.L. Impact of the Reclassification of the Non-Invasive Follicular Variant of Papillary Carcinoma as Benign on the Malignancy Risk of the Bethesda System for Reporting Thyroid Cytopathology: A Meta-Analysis Study. Acta Cytol. 2017;61:187–193. doi: 10.1159/000469654. PubMed DOI

Bongiovanni M., Faquin W.C., Giovanella L., Durante C., Kopp P., Trimboli P. Impact of non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) on risk of malignancy in patients undergoing lobectomy/thyroidectomy for suspected malignancy or malignant fine-needle aspiration cytology findings: A systematic review and meta-analysis. Eur. J. Endocrinol. 2019;181:389–396. doi: 10.1530/EJE-19-0223. PubMed DOI PMC

Chereau N., Greilsamer T., Mirallié E., Sadowski S.M., Pusztaszeri M., Triponez F., Baud G., Pattou F., Christou N., Mathonnet M., et al. NIFT-P: Are they indolent tumors? Results of a multi-institutional study. Surgery. 2019;165:12–16. doi: 10.1016/j.surg.2018.04.089. PubMed DOI

Mao M.L., Joyal T., Picado O., Kerr D., Lew J.I., Farrá J.C. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features reclassification and its impact on thyroid malignancy rate and treatment. J. Surg. Res. 2018;230:47–52. doi: 10.1016/j.jss.2018.04.013. PubMed DOI

Kiernan C.M., Weiss V.L., Mehrad M., Ely K., Baregamian N., Solórzano C.C. New terminology-noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) and its effect on the rate of malignancy at a single institution. Surgery. 2018;163:55–59. doi: 10.1016/j.surg.2017.04.041. PubMed DOI

Kakudo K. How to handle borderline/precursor thyroid tumors in management of patients with thyroid nodules. Gland Surg. 2018;7:S8–S18. doi: 10.21037/gs.2017.08.02. PubMed DOI PMC

Kakudo K. Unsettled issues in Non-invasive encapsulated/well circumscribed follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and precursor thyroid tumors. J. Basic Clin. Med. 2017;6:3–7.