The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science-policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science-policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientific networks and to intensify science-policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientific knowledge explaining the anticipated benefit for human and environmental health.

Catalan Institute of Water Research Carrer Emili Grahit 101 17003 Girona Spain

Center for Applied Geoscience Eberhard Karls University of Tübingen 72076 Tübingen Germany

Centre for Pollution Research and Policy Department of Life Sciences College of Health Medicine and Life Sciences Brunel University London Uxbridge UB8 3PH UK

Centre of Chemical Safety and Risks School of the Environment Nanjing University Nanjing China

Departamento de Química Física Facultad de Ciencias del Mar y Ambientales Universidad de Cádiz European Universities of the Seas Campus Río San Pedro 11510 Puerto Real Cádiz Spain

Department Environment and Health Vrije Universiteit Amsterdam De Boelelaan 1085 1081 HV Amsterdam The Netherlands

Department of Biological Sciences Moi University 3900 30100 Eldoret Kenya

Department of Chemistry and Biochemistry University of South Carolina Columbia SC 29208 USA

Department of Civil and Environmental Engineering and Nireas International Water Research Center University of Cyprus P O Box 20537 1678 Nicosia Cyprus

Department of Civil and Environmental Engineering National University of Singapore 1 Engineering Drive 2 Singapore Singapore

Department of Environmental Science Radbound University Nijmegen Nijmegen The Netherlands

Department of Environmental Sciences Istituto di Ricerche Farmacologiche Mario Negri IRCCS Via Mario Negri 2 20156 Milan Italy

Dept Environment and Geography University of York York N Yorkshire YO10 5DD UK

Eawag Swiss Federal Institute of Aquatic Science and Technology 8600 Dübendorf Switzerland

Environmental Institute Okruzna 784 42 97241 Kos Slovak Republic

Environmental Safety Center Tokyo University of Science 12 1 Ichigaya Funagawara Shinjuku Tokyo 162 0826 Japan

Faculty Biological Sciences Goethe University Frankfurt Max von der Laue Straße 13 60438 Frankfurt Germany

Faculty of Sciences University of Novi Sad Novi Sad Serbia

Faculty of Technology UNICAMP Limeira 13484 332 Brazil

INERIS Direction Milieu et Impacts sur le Vivant Parc technologique ALATA 60550 Verneuil en Halatte France

Institute for Nanotechnology and Water Sustainability University of South Africa Pretoria South Africa

Institute for Social Ecological Research Hamburger Alee 45 60486 Frankfurt Germany

Institute for Sustainable Chemistry Leuphana University Lüneburg Universitätsallee 1 21335 Lüneburg Germany

Institute of Biogeochemistry and Pollutant Dynamics ETH Zurich 8092 Zurich Switzerland

Institute of Chemistry UNICAMP Campinas 13083 970 Brazil

Nanyang Environment and Water Research Institute Nanyang Technological University Singapore Singapore

NILU Norwegian Institute for Air Research P O Box 100 2027 Kjeller Norway

Norwegian Institute for Water Research Environmental Chemistry and Technology Oslo Norway

Quantitative Sustainability Assessment Department of Technology Management and Economics Technical University of Denmark Produktionstorvet 424 2800 Kgs Lyngby Denmark

Queensland Alliance for Environmental Health Sciences The University of Queensland 20 Cornwall Street Woolloongabba QLD 4102 Australia

RECETOX Faculty of Science Masaryk University Kotlarska 2 Brno Czech Republic

Research Institute for Pesticides and Water University Jaume 1 12006 Castellon Spain

RIVM National Institute for Public Health and the Environment PO Box 1 3720 BA Bilthoven The Netherlands

RWTH Aachen University Worringerweg 1 52074 Aachen Germany

School of Civil and Environmental Engineering University of New South Wales Sydney NSW 2052 Australia

Spanish National Research Council Institute for Environmental Assessment and Water Research Water and Soil Quality Research Group Jordi Girona 18 26 08034 Barcelona Spain

Stanford University Stanford CA 94305 4020 USA

The French Water Academy 51 rue Salvador Allende 92027 Nanterre France

Toxicological Center University of Antwerp Universiteitsplen 1 2610 Wilrijk Belgium

UFZ Helmholtz Centre for Environmental Research Permoserstraße 15 04318 Leipzig Germany

Université de Bordeaux 351 crs de la Libération 33405 Talence France

Université Paris Saclay INRAE AgroParisTech UMR ECOSYS 78026 Versailles France

University of Bath Bath BA2 7AY UK

University of Brasilia Brasília DF 70910 000 Brazil

University of Luxembourg 6 avenue du Swing 4367 Belvaux Luxembourg

VNU Key Laboratory of Analytical Technology for Environmental Quality Vietnam National University 334 Nguyen Trai Hanoi Vietnam

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Quantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison

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