Gold nanoparticles (AuNPs) have diverse applications in the diagnosis and treatment of ailments. This study describes an extremely simplified synthesis of AuNPs using antioxidant-rich pollen extract as a local natural source. Ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to characterize the synthesized AuNPs; strong UV-vis absorption at 534 nm confirmed their formation, the XRD pattern showed the presence of a crystalline structure, and TEM images showed them to be spherical nanoparticles with an average size of 9.3 ± 2.9 nm. As synthesized AuNPs remained stable for up to two months under laboratory conditions without any sedimentation or change in the absorption value, presumably due to the protection afforded by the capping agents from pollen. AuNPs revealed low toxicity effects on MCF-7 and HUVECs cell lines (with an IC50 value of ∼400 μg mL-1 for both the cell lines). The proposed method did not use any hazardous materials or high-energy consuming devices; thus this efficient protocol may be adapted for large-scale production using local resources.

Cell Therapy and Regenerative Medicine Comprehensive Center Kerman University of Medical Sciences Kerman Iran

Department of Medical Biotechnology Faculty of Medical Sciences Tarbiat Modares University Tehran Iran 98 3433257543 98 3433257316

Medical Ethics and Law Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

Noncommunicable Diseases Research Center Bam University of Medical Sciences Bam Iran

Regional Centre of Advanced Technologies and Materials Department of Physical Chemistry Faculty of Science Palacky University Šlechtitelů 27 783 71 Olomouc Czech Republic

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Khatami M. Alijani H. Q. Fakheri B. Mobasseri M. M. Heydarpour M. Farahani Z. K. Khan A. U. J. Cleaner Prod. 2019;208:1171–1177. doi: 10.1016/j.jclepro.2018.10.182. DOI

Sargazi G. Afzali D. Mostafavi A. Shadman A. Rezaee B. Zarrintaj P. Saeb M. R. Ramakrishna S. Mozafari M. Heliyon. 2019;5:e01527. doi: 10.1016/j.heliyon.2019.e01527. PubMed DOI PMC

Safaei M. Foroughi M. M. Ebrahimpoor N. Jahani S. Omidi A. Khatami M. TrAC, Trends Anal. Chem. 2019;118:401–425. doi: 10.1016/j.trac.2019.06.007. DOI

Nazari-Vanani R. Sattarahmady N. Yadegari H. Khatami M. Heli H. Biosens. Bioelectron. 2019;142:111541. doi: 10.1016/j.bios.2019.111541. PubMed DOI

Khan Z. U. H. Khan A. Chen Y. Shah N. S. Muhammad N. Khan A. U. Tahir K. Khan F. U. Murtaza B. Hassan S. U. Qaisrani S. A. Wan P. J. Photochem. Photobiol., B. 2017;173:150–164. doi: 10.1016/j.jphotobiol.2017.05.034. PubMed DOI

Salazar-González J. A. González-Ortega O. Rosales-Mendoza S. Expert Rev. Vaccines. 2015;14:1197–1211. doi: 10.1586/14760584.2015.1064772. PubMed DOI

Iravani S. Korbekandi H. Mirmohammadi S. V. Zolfaghari B. Res. Pharm. Sci. 2014;9:385–406. PubMed PMC

Miri A. Khatami M. Sarani M. J. Inorg. Organomet. Polym. Mater. 2020;30:767–774. doi: 10.1007/s10904-019-01245-6. DOI

Miri J. Darroudi S. Sarani S. Appl. Organomet. Chem. 2020;34:5308–5309. doi: 10.1002/aoc.5308. DOI

Ghazal S. Akbari A. Hosseini H. A. Sabouri Z. Khatami M. Darroudi M. Inorg. Chem. Res. 2021;5:37–49.

Scaramuzza S. Zerbetto M. Amendola V. J. Phys. Chem. C. 2016;120:9453–9463. doi: 10.1021/acs.jpcc.6b00161. DOI

Maroušek J. Hašková S. Maroušková A. Myšková K. Vaníčková R. Váchal J. Vochozka M. Zeman R. Žák J. Energy Sources, Part A. 2015;37:1723–1728. doi: 10.1080/15567036.2015.1048391. DOI

Karthik K. Dhanuskodi S. Gobinath C. Prabukumar S. Sivaramakrishnan S. Mater. Res. Innovations. 2018;23(5):1–9.

Maroušek J. Stehel V. Vochozka M. Maroušková A. Kolář L. J. Cleaner Prod. 2018;199:173–176. doi: 10.1016/j.jclepro.2018.07.183. DOI

Khatami M. Sharifi I. Nobre M. A. L. Zafarnia N. Aflatoonian M. R. Green Chem. Lett. Rev. 2018;11:125–134. doi: 10.1080/17518253.2018.1444797. DOI

Azhdari S. Sarabi R. E. Rezaeizade N. Mosazade F. Heidari M. Borhani F. Abdollahpour-Alitappeh M. Khatami M. RSC Adv. 2020;10:29737–29744. doi: 10.1039/D0RA04071A. PubMed DOI PMC

Alinaghi Langari A. Soltaninezhad S. Zafarnia N. Heidari M. Varma R. S. Ebrahimi Z. Azhdari S. Borhani F. Khatami M. Bioprocess Biosyst. Eng. 2020;43:1–7. doi: 10.1007/s00449-019-02195-6. PubMed DOI

Chandran S. P. Chaudhary M. Pasricha R. Ahmad A. Sastry M. Biotechnol. Prog. 2006;22:577–583. doi: 10.1021/bp0501423. PubMed DOI

Montes M. O. Mayoral A. Deepak F. L. Parsons J. G. Jose-Yacamán M. Peralta-Videa J. R. Gardea-Torresdey J. L. J. Nanopart. Res. 2011;13:3113–3121. doi: 10.1007/s11051-011-0230-5. DOI

Sattarahmady N. Firoozabadi V. Nazari-Vanani R. Azarpira N. Int. J. Biol. Macromol. 2018;112:703–711. doi: 10.1016/j.ijbiomac.2018.02.025. PubMed DOI

Schulte F. Lingott J. Panne U. Kneipp J. Anal. Chem. 2008;80:9551–9556. doi: 10.1021/ac801791a. PubMed DOI

Wang X. Teng Z. Wang H. Wang C. Liu Y. Tang Y. Wu J. Sun J. Wang H. Wang J. Lu G. Int. J. Clin. Exp. Pathol. 2014;7:1337–1347. PubMed PMC

El-Naggar M. E. Shaheen T. I. Fouda M. M. G. Hebeish A. A. Carbohydr. Polym. 2016;136:1128–1136. doi: 10.1016/j.carbpol.2015.10.003. PubMed DOI

Ravindra P. Mater. Sci. Eng., B. 2009;163:93–98. doi: 10.1016/j.mseb.2009.05.013. DOI

Filippo E. Serra A. Buccolieri A. Manno D. J. Non-Cryst. Solids. 2010;356:344–350. doi: 10.1016/j.jnoncrysol.2009.11.021. DOI

Egorova E. Revina A. Colloids Surf., A. 2000;168:87–96. doi: 10.1016/S0927-7757(99)00513-0. DOI

Engelbrekt C. Sorensen K. H. Zhang J. Welinder A. C. Jensen P. S. Ulstrup J. J. Mater. Chem. 2009;19:7839–7847. doi: 10.1039/B911111E. DOI

Narayanan K. B. Sakthivel N. Mater. Lett. 2008;62:4588–4590. doi: 10.1016/j.matlet.2008.08.044. DOI

Shi C. Zhu N. Cao Y. Wu P. Nanoscale Res. Lett. 2015;10:147. doi: 10.1186/s11671-015-0856-9. PubMed DOI PMC

Vijayakumar S. J. Saudi Chem. Soc. 2019;23:753–761. doi: 10.1016/j.jscs.2018.12.002. DOI

Barai A. C. Paul K. Dey A. Manna S. Roy S. Bag B. G. Mukhopadhyay C. Nano Convergence. 2018;5:10. doi: 10.1186/s40580-018-0142-5. PubMed DOI PMC

Anbu P. Gopinath S. C. Jayanthi S. Nanomater. Nanotechnol. 2020;10:1847980420961697.

Khatua A. Priyadarshini E. Rajamani P. Patel A. Kumar J. Naik A. Saravanan M. Barabadi H. Prasad A. Ghosh l. Paul B. Meena R. J. Cluster Sci. 2020;31:125–131. doi: 10.1007/s10876-019-01624-6. DOI

Dorosti N. Jamshidi F. J. Appl. Biomed. 2016;14:235–245. doi: 10.1016/j.jab.2016.03.001. DOI

Kajani A. A. Bordbar A.-K. Esfahani S. H. Z. Razmjou A. RSC Adv. 2016;6:63973–63983. doi: 10.1039/C6RA09050H. DOI

Anand K. Gengan R. Phulukdaree A. Chuturgoon A. J. Ind. Eng. Chem. 2015;21:1105–1111. doi: 10.1016/j.jiec.2014.05.021. DOI

Wongyai K. Wintachai P. Maungchang R. Rattanakit P. J. Nanomater. 2020;2020:1320274. doi: 10.1155/2020/1320274. DOI

Ankamwar B. Eur. J. Chem. 2010;7:745120.

Muthukumar T. Sambandam B. Aravinthan A. Sastry T. P. Kim J.-H. Process Biochem. 2016;51:384–391. doi: 10.1016/j.procbio.2015.12.017. DOI

Balasubramanian S. Kala S. M. J. Pushparaj T. L. J. Drug Delivery Sci. Technol. 2020;57:101620. doi: 10.1016/j.jddst.2020.101620. DOI

Nejad M. S. Khatami M. Bonjar G. H. S. IET Nanobiotechnol. 2016;10:33–38. doi: 10.1049/iet-nbt.2015.0028. PubMed DOI PMC

Shabestarian H. Homayouni-Tabrizi M. Soltani M. Namvar F. Azizi S. Mohamad R. Shabestarian H. Materials Research. 2017;20:264–270. doi: 10.1590/1980-5373-mr-2015-0694. DOI

Xin Lee K. Shameli K. Miyake M. Kuwano N. Bt Ahmad Khairudin N. B. Bt Mohamad S. E. Yew Y. P. J. Nanomater. 2016;2016:7. PubMed PMC

Singh A. K. Srivastava O. N. Nanoscale Res. Lett. 2015;10:353. doi: 10.1186/s11671-015-1055-4. PubMed DOI PMC

Elia P. Zach R. Hazan S. Kolusheva S. Porat Z. e. Zeiri Y. Int. J. Nanomed. 2014;9:4007–4021. PubMed PMC

Pani A. Thanh T. D. Kim N. H. Lee J. H. Yun S.-I. IET Nanobiotechnol. 2016;10:431–437. doi: 10.1049/iet-nbt.2016.0017. PubMed DOI PMC

Li J. Li Q. Ma X. Tian B. Li T. Yu J. Dai S. Weng Y. Hua Y. Int. J. Nanomed. 2016;11:5931–5944. doi: 10.2147/IJN.S119618. PubMed DOI PMC

Wang C. Mathiyalagan R. Kim Y. J. Castro-Aceituno V. Singh P. Ahn S. Wang D. Yang D. C. Int. J. Nanomed. 2016;11:3691. doi: 10.2147/IJN.S97181. PubMed DOI PMC

Castro-Aceituno V. Abbai R. Moon S. S. Ahn S. Mathiyalagan R. Kim Y.-J. Kim Y.-J. Yang D. C. Biomed. Pharmacother. 2017;93:995–1003. doi: 10.1016/j.biopha.2017.07.040. PubMed DOI

Lee S. Y. Krishnamurthy S. Cho C.-W. Yun Y.-S. ACS Sustainable Chem. Eng. 2016;4:2651–2659. doi: 10.1021/acssuschemeng.6b00161. DOI

Bhambure R. Bule M. Shaligram N. Kamat M. Singhal R. Chem. Eng. Technol. 2009;32:1036–1041. doi: 10.1002/ceat.200800647. DOI

Priyadarshini E. Pradhan N. Sukla L. B. Panda P. K. J. Nanotechnol. 2014;2014:9.

Jha A. K. Prasad K. Int. J. Green Nanotechnol. 2011;3:92–97. doi: 10.1080/19430892.2011.574560. DOI

Castro M. E. Cottet L. Castillo A. Mater. Lett. 2014;115:42–44. doi: 10.1016/j.matlet.2013.10.020. DOI

Khalil M. M. H. Ismail E. H. El-Magdoub F. Arabian J. Chem. 2012;5:431–437. doi: 10.1016/j.arabjc.2010.11.011. DOI

Dzimitrowicz A. Jamróz P. diCenzo G. C. Sergiel I. Kozlecki T. Pohl P. Arabian J. Chem. 2019;12:4118–4130. doi: 10.1016/j.arabjc.2016.04.004. DOI

Ramakrishna M. Rajesh Babu D. Gengan R. M. Chandra S. Nageswara Rao G. J. Nanostruct. Chem. 2016;6:1–13. doi: 10.1007/s40097-015-0173-y. DOI

Fernando L. M. Merca F. E. Paterno E. S. Philipp. Agric. Scientist. 2013;96:129–136.

Gonnelli C., Giordano C., Fontani U., Salvatici M. C. and Ristori S., in Advances in Bionanomaterials: Selected Papers from the 2nd Workshop in Bionanomaterials, BIONAM 2016, October 4-7, 2016, Salerno, Italy, ed. S. Piotto, F. Rossi, S. Concilio, E. Reverchon and G. Cattaneo, Springer International Publishing, Cham, 2018, pp. 155–164, 10.1007/978-3-319-62027-5_14 DOI

Bogireddy N. Pal U. Gomez L. M. Agarwal V. RSC Adv. 2018;8:24819–24826. doi: 10.1039/C8RA04332A. PubMed DOI PMC