The direct toxicity of cancer treatment threatens patients and survivors with an increased risk of cardiovascular disease or adverse functional changes with subsequent progression of cardiovascular complications. An accumulation of cardiovascular risk factors combined with an unhealthy lifestyle has recently become more common in cancer patients and survivors. It has been recommended to integrate a comprehensive cardiac rehabilitation model called cardio-oncology rehabilitation to mitigate cardiovascular risk. Nevertheless, cardiac rehabilitation interventions limit barriers in low utilization, further exacerbated by the restrictions associated with the COVID-19 pandemic. Therefore, it is essential to integrate alternative interventions such as telehealth, which can overcome several barriers. This literature review was designed as a framework for developing and evaluating telehealth interventions and mobile applications for comprehensive cardio-oncology rehabilitation. We identify knowledge gaps and propose strategies to facilitate the development and integration of cardio-oncology rehabilitation telehealth as an alternative approach to the standard of care for cancer patients and survivors. Despite the limited evidence, the pilot results from included studies support the feasibility and acceptability of telehealth and mobile technologies in cardio-oncology rehabilitation. This new area suggests that telehealth interventions are feasible and induce physiological and psychological benefits for cancer patients and survivors. There is an assumption that telehealth interventions and exercise may be an effective future alternative approach in supportive cancer care.

Clinical Exercise Physiology and Rehabilitation Research Laboratory Physiotherapy Department School of Health Sciences University of Thessaly Lamia Greece

Department of Health Sciences Faculty of Medicine Masaryk University Brno Czechia

Department of Internal Medicine and Cardiology University Hospital Brno Brno Czechia

Department of Internal Medicine Hematology and Oncology University Hospital Brno Brno Czechia

Department of Kinesitherapy Faculty of Public Health Prof Dr Tzecomir Vodenicharov Ph D Medical University of Sofia Sofia Bulgaria

Department of Medical Imaging Allergology and Physiotherapy Faculty of Dental Medicine Medical University of Plovdiv Plovdiv Bulgaria

Department of Neurology University Hospital Brno Brno Czechia

Department of Public Health Faculty of Medicine Masaryk University Brno Czechia

Department of Rehabilitation University Hospital Brno Brno Czechia

Faculty of Arts Department of Physical Education and Sports Matej Bel University Banská Bystrica Slovakia

Faculty of Medicine Masaryk University Brno Czechia

Faculty of Physical Education and Physiotherapy Opole University of Technology Opole Poland

Physiotherapy Department University of West Attica Athens Greece

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The Digital Revolution in Medicine: Applications in Cardio-Oncology

Feasibility, safety, and adherence of home-based exercise interventions in people diagnosed with cancer: a systematic review

Effects of home-based exercise with telehealth guidance in lymphoma cancer survivors entering cardio-oncology rehabilitation: rationale and design of the tele@home study

Effect of exercise-based cancer rehabilitation via telehealth: a systematic review and meta-analysis

Efficacy of supervised home-based, real time, videoconferencing telerehabilitation in patients with type 2 diabetes: a single-blind randomized controlled trial

The cost-effectiveness of exercise-based cardiac telerehabilitation intervention: a systematic review

Home-based cardio-oncology rehabilitation using a telerehabilitation platform in hematological cancer survivors: a feasibility study