In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking selectivity to cancer cells compared to noncancerous human fibroblasts. The data reveal that the complex induces ferroptosis in rhabdomyosarcoma cells, likely due to interfering with iron metabolism. Importantly, it can kill both bulk and stem rhabdomyosarcoma cells. To the best of our knowledge, this is the first compound based on metal other than Fe capable of inducing ferroptosis in cancer cells.

Czech Academy of Sciences Institute of Biophysics Brno 61265 Czech Republic

Department of Biophysics Faculty of Science Palacky University in Olomouc Olomouc 78371 Czech Republic

Department of Inorganic Chemistry Institute of Chemistry P J Šafárik University in Košice Košice 04001 Slovakia

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