Antibody-pHPMA functionalised fluorescent silica nanoparticles for colorectal carcinoma targeting
Status PubMed-not-MEDLINE Jazyk angličtina Země Velká Británie, Anglie Médium electronic-ecollection
Typ dokumentu časopisecké články
PubMed
35541757
PubMed Central
PMC9081219
DOI
10.1039/c8ra03487g
PII: c8ra03487g
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
The systemic application of highly potent drugs such as cytostatics poses the risks of side effects, which could be reduced by using a carrier system able to specifically deliver the encapsulated drug to the target tissue. Essential components of a nanoparticle-based drug delivery system include the drug carrier itself, a targeting moiety, and a surface coating that minimizes recognition by the immune system. The present work reports on the preparation, in vitro characterization and in vivo testing of a new delivery system consisting of fluorescent silica nanoparticles functionalised with a non-immunogenic stealth polymer poly(N-(2-hydroxypropyl)methacrylamide) (pHPMA) and a monoclonal antibody IgG M75 that specifically binds to Carbonic Anhydrase IX (CA IX). CA IX is a promising therapeutic target, as it is a hallmark of several hypoxic tumours including colorectal carcinoma. Uniquely in this work, the monoclonal antibody was covalently coupled to the surface of fluorescently labelled silica nanoparticles via a multivalent amino-reactive co-polymer rather than a traditional bivalent linker. The pHPMA-M75 functionalised SiO2 nanoparticles exhibited excellent colloidal stability in physiological media. Their in vitro characterisation by flow cytometry proved a highly specific interaction with colorectal carcinoma cells HT-29. In vivo study on athymic NU/NU nude mice revealed that the SiO2-pHPMA-M75 nanoparticles are capable of circulating in the blood after intravenous administration and accumulate in the tumour at tenfold higher concentration than nanoparticles without specific targeting, with a considerably longer retention time. Additionally, it was found that by reducing the dose administered in vivo, the selectivity of the nanoparticle biodistribution could be further enhanced in favour of the tumour.
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Owens III D. E. Peppas N. A. Int. J. Pharm. 2006;307:93–102. doi: 10.1016/j.ijpharm.2005.10.010. PubMed DOI
Moghimi S. M. Szebeni J. Prog. Lipid Res. 2003;42:463–478. doi: 10.1016/S0163-7827(03)00033-X. PubMed DOI
Illum L. Davis S. Müller R. Mak E. West P. Life Sci. 1987;40:367–374. doi: 10.1016/0024-3205(87)90138-X. PubMed DOI
Dobrovolskaia M. A. Aggarwal P. Hall J. B. McNeil S. E. Mol. Pharm. 2008;5:487–495. doi: 10.1021/mp800032f. PubMed DOI PMC
Parveen S. Sahoo S. K. Eur. J. Pharmacol. 2011;670:372–383. doi: 10.1016/j.ejphar.2011.09.023. PubMed DOI
Aggarwal P. Hall J. B. McLeland C. B. Dobrovolskaia M. A. McNeil S. E. Adv. Drug Delivery Rev. 2009;61:428–437. doi: 10.1016/j.addr.2009.03.009. PubMed DOI PMC
Walkey C. D. Olsen J. B. Guo H. Emili A. Chan W. C. J. Am. Chem. Soc. 2012;134:2139–2147. doi: 10.1021/ja2084338. PubMed DOI
Decuzzi P. Godin B. Tanaka T. Lee S.-Y. Chiappini C. Liu X. Ferrari M. J. Controlled Release. 2010;141:320–327. doi: 10.1016/j.jconrel.2009.10.014. PubMed DOI
Moghimi S. M. Hunter A. C. Murray J. C. Pharmacogn. Rev. 2001;53:283–318. PubMed
Cheng J. Teply B. A. Sherifi I. Sung J. Luther G. Gu F. X. Levy-Nissenbaum E. Radovic-Moreno A. F. Langer R. Farokhzad O. C. Biomaterials. 2007;28:869–876. doi: 10.1016/j.biomaterials.2006.09.047. PubMed DOI PMC
Hans M. Lowman A. Curr. Opin. Solid State Mater. Sci. 2002;6:319–327. doi: 10.1016/S1359-0286(02)00117-1. PubMed DOI
Knop K. Hoogenboom R. Fischer D. Schubert U. S. Angew. Chem., Int. Ed. 2010;49:6288–6308. doi: 10.1002/anie.200902672. PubMed DOI
Calvo D. Jesús M. Lee D.-H. Rev. Esp. Cardiol. 2006;59:399–400. doi: 10.1157/13087068. PubMed DOI
Szebeni J. Toxicology. 2005;216:106–121. doi: 10.1016/j.tox.2005.07.023. PubMed DOI
Chanan-Khan A. Szebeni J. Savay S. Liebes L. Rafique N. Alving C. Muggia F. Ann. Oncol. 2003;14:1430–1437. doi: 10.1093/annonc/mdg374. PubMed DOI
Szebeni J. Baranyi L. Savay S. Milosevits J. Bunger R. Laverman P. Metselaar J. Storm G. Chanan-Khan A. Liebes L. J. Liposome Res. 2002;12:165–172. doi: 10.1081/LPR-120004790. PubMed DOI
Duncan R. Nat. Rev. Cancer. 2006;6:688. doi: 10.1038/nrc1958. PubMed DOI
Lammers T. Kühnlein R. Kissel M. Subr V. Etrych T. Pola R. Pechar M. Ulbrich K. Storm G. Huber P. J. Controlled Release. 2005;110:103–118. doi: 10.1016/j.jconrel.2005.09.010. PubMed DOI
Kunjachan S. Gremse F. Theek B. Koczera P. Pola R. Pechar M. Etrych T. Ulbrich K. Storm G. Kiessling F. ACS Nano. 2012;7:252–262. doi: 10.1021/nn303955n. PubMed DOI PMC
Pechar M. Pola R. Laga R. Ulbrich K. Bednárová L. Maloň P. Sieglová I. Král V. Fábry M. Vaněk O. Biomacromolecules. 2011;12:3645–3655. doi: 10.1021/bm200897b. PubMed DOI
Šubr V. Koňák Č. Laga R. Ulbrich K. Biomacromolecules. 2006;7:122–130. doi: 10.1021/bm050524x. PubMed DOI
Koňák Č. Šubr V. Kostka L. Štěpánek P. Ulbrich K. Schlaad H. Langmuir. 2008;24:7092–7098. doi: 10.1021/la800119w. PubMed DOI
Klepac D. Kostkova H. Petrova S. Chytil P. Etrych T. Kereïche S. Raska I. Weitz D. A. Filippov S. K. Nanoscale. 2018;10:6194–6204. doi: 10.1039/C7NR09355A. PubMed DOI
Green N. Herbert C. W. Hale S. Hale A. Mautner V. Harkins R. Hermiston T. Ulbrich K. Fisher K. Seymour L. Gene Ther. 2004;11:1256. doi: 10.1038/sj.gt.3302295. PubMed DOI
Král V. Mader P. Collard R. Fábry M. Hořejší M. Řezáčová P. Kožíšek M. Závada J. Sedláček J. Rulíšek L. Proteins: Struct., Funct., Bioinf. 2008;71:1275–1287. doi: 10.1002/prot.21821. PubMed DOI
Pastorekova S. Parkkila S. Parkkila A. K. Opavsky R. Zelnik V. Saarnio J. Pastorek J. Gastroenterology. 1997;112:398–408. doi: 10.1053/gast.1997.v112.pm9024293. PubMed DOI
McDonald P. C. Winum J.-Y. Supuran C. T. Dedhar S. Oncotarget. 2012;3:84. doi: 10.18632/oncotarget.422. PubMed DOI PMC
Zavada J. Zavadova Z. Pastorek J. Biesova Z. Jezek J. Velek J. Br. J. Cancer. 2000;82:1808. doi: 10.1054/bjoc.2000.1111. PubMed DOI PMC
Chrastina A. Zavada J. Parkkila S. Kaluz Š. Kaluzová M. Rajčáni J. Pastorek J. Pastoreková S. Int. J. Cancer. 2003;105:873–881. doi: 10.1002/ijc.11142. PubMed DOI
Tokárová V. Pittermannová A. Král V. Řezáčová P. Štěpánek F. Nanoscale. 2013;5:11490–11498. doi: 10.1039/C3NR04340A. PubMed DOI PMC
Ullrich M. Haša J. Hanuš J. Šoóš M. Štěpánek F. Powder Technol. 2016;295:115–121. doi: 10.1016/j.powtec.2016.03.021. DOI
Watermann A. Brieger J. Nanomaterials. 2017;7:189. doi: 10.3390/nano7070189. PubMed DOI PMC
Zhang Y. Guo J. Zhang X.-L. Li D.-P. Zhang T.-T. Gao F.-F. Liu N.-F. Sheng X.-G. Int. J. Pharm. 2015;496:1026–1033. doi: 10.1016/j.ijpharm.2015.10.080. PubMed DOI
Bouchoucha M. Béliveau É. Kleitz F. Calon F. Fortin M.-A. J. Mater. Chem. B. 2017;5:7721–7735. doi: 10.1039/C7TB01385J. PubMed DOI
Mandal T. Beck M. Lindén M. Buske C. Blood. 2016;128:4713.
Chen F. Hong H. Zhang Y. Valdovinos H. F. Shi S. Kwon G. S. Theuer C. P. Barnhart T. E. Cai W. ACS Nano. 2013;7:9027–9039. doi: 10.1021/nn403617j. PubMed DOI PMC
Wang J.-K. Zhou Y.-Y. Guo S.-J. Wang Y.-Y. Nie C.-J. Wang H.-l. Wang J.-l. Zhao Y. Li X.-Y. Chen X.-J. Mater. Sci. Eng., C. 2017;76:944–950. doi: 10.1016/j.msec.2017.03.131. PubMed DOI
Clinical Trial ID no. NCT02106598, Targeted Silica Nanoparticles for Real-Time Image-Guided Intraoperative Mapping of Nodal Metastases
Owens III D. E. Peppas N. A. Int. J. Pharm. 2006;307:93–102. doi: 10.1016/j.ijpharm.2005.10.010. PubMed DOI
Cataldi M. Vigliotti C. Mosca T. Cammarota M. Capone D. Int. J. Mol. Sci. 2017;18:1249. doi: 10.3390/ijms18061249. PubMed DOI PMC
Blanco E. Shen H. Ferrari M. Nat. Biotechnol. 2015;33:941. doi: 10.1038/nbt.3330. PubMed DOI PMC
Etrych T. Mrkvan T. Chytil P. Koňák Č. Říhová B. Ulbrich K. J. Appl. Polym. Sci. 2008;109:3050–3061. doi: 10.1002/app.28466. DOI
Pastoreková S. Závadová Z. Košťál M. Babušíková O. Závada J. Virology. 1992;187:620–626. doi: 10.1016/0042-6822(92)90464-Z. PubMed DOI
Stöber W. Fink A. Bohn E. J. Colloid Interface Sci. 1968;26:62–69. doi: 10.1016/0021-9797(68)90272-5. DOI
Čejková J. Hanuš J. Štěpánek F. J. Colloid Interface Sci. 2010;346:352–360. doi: 10.1016/j.jcis.2010.02.060. PubMed DOI
Bangs Laboratories, Inc., TechNote 205: Covalent Coupling, 2013
Touisni N. Kanfar N. Ulrich S. Dumy P. Supuran C. T. Mehdi A. Winum J.-Y. Chem.–Eur. J. 2015;21:10306–10309. doi: 10.1002/chem.201501037. PubMed DOI