Subgroup analysis based on cytogenetic risk in patients with relapsed or refractory multiple myeloma in the CANDOR study
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural
Grant support
P30 CA240139
NCI NIH HHS - United States
PubMed
35608261
DOI
10.1111/bjh.18233
Knihovny.cz E-resources
- Keywords
- carfilzomib, cytogenetics, proteasome inhibitor, relapsed or refractory multiple myeloma,
- MeSH
- Cytogenetic Analysis MeSH
- Dexamethasone therapeutic use MeSH
- Adult MeSH
- Humans MeSH
- Multiple Myeloma * drug therapy genetics MeSH
- Prognosis MeSH
- Antineoplastic Combined Chemotherapy Protocols * adverse effects MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Names of Substances
- Dexamethasone MeSH
CANDOR compared the safety/efficacy of carfilzomib with dexamethasone and daratumumab (KdD) to carfilzomib with dexamethasone (Kd) in adults with relapsed/refractory multiple myeloma (RRMM). This CANDOR subgroup analysis evaluated outcomes based on cytogenetic risk. Overall response rates (KdD vs. Kd) were 81% versus 56% in high-risk and 87% versus 79% in standard-risk groups. Median progression-free survival was 11.2 versus 7.4 months in high-risk (hazard ratio, 0.56 [95% CI, 0.34, 0.93]) and not reached versus 16.6 months in standard-risk groups (0.56 [95% CI, 0.39, 0.80]). These data support the efficacy of KdD in RRMM treatment, including in patients with high-risk cytogenetics.
Amgen Inc Thousand Oaks California USA
Department of Haematooncology Faculty of Medicine University of Ostrava Ostrava Czech Republic
Department of Haematooncology University Hospital Ostrava Ostrava Czech Republic
Division of Hematology Sylvester Comprehensive Cancer Center Miami Florida USA
Hospital Clínic IDIBAPS Barcelona Spain
Memorial Sloan Kettering Cancer Center New York New York USA
Service d'hématologie Clinique Centre Hospitalier Universitaire de Nantes Nantes France
Yonsei University College of Medicine Severance Hospital Seoul Republic of South Korea
See more in PubMed
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