Divergent gut microbiota in two closely related house mouse subspecies under common garden conditions
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
35767862
DOI
10.1093/femsec/fiac078
PII: 6620832
Knihovny.cz E-resources
- Keywords
- Helicobacter, evolution, gut microbiome, metabarcoding, seminatural breeding, speciation,
- MeSH
- Host Microbial Interactions MeSH
- Mice MeSH
- RNA, Ribosomal, 16S genetics MeSH
- Gastrointestinal Microbiome * MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- RNA, Ribosomal, 16S MeSH
The gastrointestinal microbiota (GM) is considered an important component of the vertebrate holobiont. GM-host interactions influence the fitness of holobionts and are, therefore, an integral part of evolution. The house mouse is a prominent model for GM-host interactions, and evidence suggests a role for GM in mouse speciation. However, previous studies based on short 16S rRNA GM profiles of wild house mouse subspecies failed to detect GM divergence, which is a prerequisite for the inclusion of GM in Dobzhansky-Muller incompatibilities. Here, we used standard 16S rRNA GM profiling in two mouse subspecies, Mus musculus musculus and M. m. domesticus, including the intestinal mucosa and content of three gut sections (ileum, caecum, and colon). We reduced environmental variability by sampling GM in the offspring of wild mice bred under seminatural conditions. Although the breeding conditions allowed a contact between the subspecies, we found a clear differentiation of GM between them, in all three gut sections. Differentiation was mainly driven by several Helicobacters and two H. ganmani variants showed a signal of codivergence with their hosts. Helicobacters represent promising candidates for studying GM-host coadaptations and the fitness effects of their interactions.
Department of Zoology Faculty of Science Charles University Prague Czech Republic
Institute of Animal Physiology and Genetics Czech Academy of Sciences Brno Czech Republic
References provided by Crossref.org
Aberrant microbiomes are associated with increased antibiotic resistance gene load in hybrid mice
