Micro/nano biomimetic systems that convert energy from the surroundings into mechanical motion have emerged as promising tools to enhance the efficiencies of different biomedical and environmental processes. The inclusion of multiple engines into the same device has become a promising strategy to achieve dual/triple stimuli responses. Such hybrid micro/nanoswimmers combining different propulsion forces exhibit advanced motion behaviors and different physical features that are interesting not only to achieve strong propulsion capabilities in complex environments but also to modulate their movement according to the intended use. The development of hybrid systems that can be actuated by both light and biocompatible fuels is of particular interest. This minireview covers the main types of photoactive/biocatalytic micro/nanoswimmers developed so far. Their main photoresponsive and enzymatic components are discussed along with the most representative designs. The applicability of such hybrid machines for analyte sensing, antibacterial and therapeutical uses is also described. The remaining challenges and opportunities are then explored.

Department of Inorganic Chemistry Faculty of Chemical Technology University of Chemistry and Technology Prague Technická 5 166 28 Prague 6 Czech Republic

Institute of Chemical Research of Catalonia Av Països Catalans 16 Tarragona E 43007 Spain

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W. F. Paxton, K. C. Kistler, C. C. Olmeda, A. Sen, S. K. St. Angelo, Y. Cao, T. E. Mallouk, P. E. Lammert, V. H. Crespi, J. Am. Chem. Soc. 2004, 126, 13424-13431;

S. Fournier-Bidoz, A. C. Arsenault, I. Manners, G. A. Ozin, Chem. Commun. 2005, 441-443.

H. Ceylan, J. Giltinan, K. Kozielski, M. Sitti, Lab Chip 2017, 17, 1705-1724;

J. Jiang, Z. Yang, A. Ferreira, L. Zhang, Adv. Intell. Syst. 2022, 4, 2100279;

F. Soto, E. Karshalev, F. Zhang, B. Esteban Fernandez de Avila, A. Nourhani, J. Wang, Chem. Rev. 2022, 122, 5365-5403;

S. Palagi, P. Fischer, Nat. Rev. Mater. 2018, 3, 113-124;

S. Chowdhury, W. Jing, D. J. Cappelleri, J. Micro-Bio Robot. 2015, 10, 1-11;

J. Li, L. Dekanovsky, B. Khezri, B. Wu, H. Zhou, Z. Sofer, Cyborg Bionic Syst. 2022, 2022, 9824057;

X. Ma, A. C. Hortelão, T. Patiño, S. Sánchez, ACS Nano 2016, 10, 9111-9122;

S. Ghosh, A. Somasundar, A. Sen, Annu. Rev. Condens. Matter Phys. 2021, 12, 177-200.

J. Sun, M. Mathesh, W. Li, D. A. Wilson, ACS Nano 2019, 13, 10191-10200;

A. C. Hortelão, R. Carrascosa, N. Murillo-Cremaes, T. Patiño, S. Sánchez, ACS Nano 2019, 13, 429-439.

H. Chen, W. Li, Y. Lin, L. Wang, X. Liu, X. Huang, Angew. Chem. Int. Ed. 2020, 59, 16953-16960;

Angew. Chem. 2020, 132, 17101-17108;

L. Wang, Y. Lin, Y. Zhou, H. Xie, J. Song, M. Li, Y. Huang, X. Huang, S. Mann, Angew. Chem. Int. Ed. 2019, 58, 1067-1071;

Angew. Chem. 2019, 131, 1079-1083;

L. Wang, S. Song, J. van Hest, L. K. E. A. Abdelmohsen, X. Huang, S. Sánchez, Small 2020, 16, 1907680.

H. Choi, S. H. Jeong, T. Y. Kim, J. Yi, S. K. Hahn, Bioact. Mater. 2022, 9, 54-62.

S. Fu, X. Zhang, Y. Xie, J. Wu, H. Ju, Nanoscale 2017, 9, 9026-9033.

Q. Wang, R. Dong, C. Wang, S. Xu, D. Chen, Y. Liang, B. Ren, W. Gao, Y. Cai, ACS Appl. Mater. Interfaces. 2019, 11, 6201-6207.

L. Wang, A. C. Hortelão, X. Huang, S. Sánchez, Angew. Chem. Int. Ed. 2019, 58, 7992-7996;

Angew. Chem. 2019, 131, 8076-8080;

L. Wang, M. Marciello, M. Estévez-Gay, P. E. D. Soto Rodriguez, Y. Luengo Morato, J. Iglesias-Fernández, X. Huang, S. Osuna, M. Filice, S. Sánchez, Angew. Chem. Int. Ed. 2020, 59, 21080-21087;

Angew. Chem. 2020, 132, 21266-21273.

H. Yuan, X. Liu, L. Wang, X. Ma, Bioact. Mater. 2021, 6, 1727-1749.

A. C. Hortelao, C. Simó, M. Guix, S. Guallar-Garrido, E. Julián, D. Vilela, L. Rejc, P. Ramos-Cabrer, U. Cossío, V. Gómez-Vallejo, T. Patiño, J. Llop, S. Sánchez, Sci. Robot. 2021, 6, eabd2823;

M. Luo, S. Li, J. Wan, C. Yang, B. Chen, J. Guan, Langmuir 2020, 36.

S. Tang, F. Zhang, H. Gong, F. Wei, J. Zhuang, E. Karshalev, B. E.-F. d. Ávila, C. Huang, Z. Zhou, Z. Li, L. Yin, H. Dong, R. H. Fang, X. Zhang, L. Zhang, J. Wang, Sci. Robot. 2020, 5, eaba6137.

X. Arqué, M. D. T. Torres, T. Patiño, A. Boaro, S. Sánchez, C. de la Fuente-Nunez, ACS Nano 2022, 16, 7547-7558;

D. Vilela, N. Blanco-Cabra, A. Eguskiza, A. C. Hortelao, E. Torrents, S. Sanchez, ACS Appl. Mater. Interfaces. 2021, 13, 14964-14973.

T. Patino, A. Porchetta, A. Jannasch, A. Lladó, T. Stumpp, E. Schäffer, F. Ricci, S. Sánchez, Nano Lett. 2019, 19, 3440-3447.

S. Pané, P. Wendel-Garcia, Y. Belce, X.-Z. Chen, J. Puigmartí-Luis, Curr. Robot. Rep. 2021, 2, 427-440;

K. Yuan, V. de la Asunción-Nadal, B. Jurado-Sánchez, A. Escarpa, Chem. Mater. 2020, 32, 1983-1992.

L. Wang, Z. Meng, Y. Chen, Y. Zheng, Adv. Intell. Syst. 2021, 3, 2000267;

Z. Wang, Z. Xu, B. Zhu, Y. Zhang, J. Lin, Y. Wu, D. Wu, Nanotechnology 2022, 33, 152001.

Q. Wang, L. Zhang, ACS Nano 2021, 15, 149-174.

M. Kaynak, A. Ozcelik, A. Nourhani, P. E. Lammert, V. H. Crespi, T. J. Huang, Lab Chip 2017, 17, 395-400;

D. Ahmed, T. Baasch, B. Jang, S. Pane, J. Dual, B. J. Nelson, Nano Lett. 2016, 16, 4968-4974.

A.-I. Bunea, D. Martella, S. Nocentini, C. Parmeggiani, R. Taboryski, D. S. Wiersma, Adv. Intell. Syst. 2021, 3, 2000256.

S. Palagi, D. P. Singh, P. Fischer, Adv. Opt. Mater. 2019, 7, 1900370;

Q. Yang, L. Xu, W. Zhong, Q. Yan, Y. Gao, W. Hong, Y. She, G. Yang, Adv. Intell. Syst. 2020, 2, 2000049.

C. Liu, J. Huang, T. Xu, X. Zhang, Microchim. Acta 2022, 189, 116.

K. Villa, F. Novotný, J. Zelenka, M. P. Browne, T. Ruml, M. Pumera, ACS Nano 2019, 13, 8135-8145;

K. Villa, C. L. Manzanares Palenzuela, Z. Sofer, S. Matějková, M. Pumera, ACS Nano 2018, 12, 12482-12491;

H. Zhou, B. Wu, L. Dekanovsky, S. Wei, B. Khezri, T. Hartman, J. Li, Z. Sofer, FlatChem 2021, 30, 100294.

L. Xu, F. Mou, H. Gong, M. Luo, J. Guan, Chem. Soc. Rev. 2017, 46, 6905-6926;

L. Wang, Y. Liu, J. He, M. J. Hourwitz, Y. Yang, J. T. Fourkas, X. Han, Z. Nie, Small 2015, 11, 3762-3767.

J. Wang, Z. Xiong, J. Zheng, X. Zhan, J. Tang, Acc. Chem. Res. 2018, 51, 1957-1965.

C. Chen, F. Soto, E. Karshalev, J. Li, J. Wang, Adv. Funct. Mater. 2019, 29, 1806290;

T. Xu, F. Soto, W. Gao, R. Dong, V. Garcia-Gradilla, E. Magaña, X. Zhang, J. Wang, J. Colloid Interface Sci. 2015, 137, 2163-2166;

J. Li, T. Li, T. Xu, M. Kiristi, W. Liu, Z. Wu, J. Wang, Nano Lett. 2015, 15, 4814-4821.

C. Chen, S. Tang, H. Teymourian, E. Karshalev, F. Zhang, J. Li, F. Mou, Y. Liang, J. Guan, J. Wang, Angew. Chem. Int. Ed. 2018, 57, 8110-8114;

Angew. Chem. 2018, 130, 8242-8246.

D. Zhou, Y. Gao, J. Yang, Y. C. Li, G. Shao, G. Zhang, T. Li, L. Li, Adv. Sci. 2018, 5, 1800122;

S. Tang, F. Zhang, J. Zhao, W. Talaat, F. Soto, E. Karshalev, C. Chen, Z. Hu, X. Lu, J. Li, Z. Lin, H. Dong, X. Zhang, A. Nourhani, J. Wang, Adv. Funct. Mater. 2019, 29, 1809003.

K. Yuan, V. de la Asunción-Nadal, B. Jurado-Sánchez, A. Escarpa, Chem. Mater. 2020, 32, 1983-1992.

Y. Hu, Z. Li, Y. Sun, J. Colloid Interface Sci. 2022, 621, 341-351.

Y. You, D. Xu, X. Pan, X. Ma, Appl. Mater. Res. 2019, 16, 508-517.

M. Liu, L. Chen, Z. Zhao, M. Liu, T. Zhao, Y. Ma, Q. Zhou, Y. S. Ibrahim, A. A. Elzatahry, X. Li, D. Zhao, J. Am. Chem. Soc. 2022, 144, 3892-3901.

K. Villa, H. Sopha, J. Zelenka, M. Motola, L. Dekanovsky, D. C. Beketova, J. M. Macak, T. Ruml, M. Pumera, Small, n/a, 2106612.

Y. Xing, S. Tang, X. Du, T. Xu, X. Zhang, Nano Res. 2021, 14, 654-659.

D. Xu, C. Zhou, C. Zhan, Y. Wang, Y. You, X. Pan, J. Jiao, R. Zhang, Z. Dong, W. Wang, X. Ma, Adv. Funct. Mater. 2019, 29, 1807727.

Y. Xing, X. Du, T. Xu, X. Zhang, Soft Matter 2020, 16, 9553-9558.

Z.-W. Gao, W. Zheng, L. Y. S. Lee, Small 2019, 15, 1902649;

K. Villa, M. Pumera, Chem. Soc. Rev. 2019, 48, 4966-4978;

J. Wang, Z. Xiong, J. Tang, Adv. Intell. Syst. 2021, 3, 2000170.

N. Yang, Y. Tian, M. Zhang, X. Peng, F. Li, J. Li, Y. Li, B. Fan, F. Wang, H. Song, Biotechnol. Adv. 2022, 54, 107808.

Active Microrobots for Dual Removal of Biofilms via Chemical and Physical Mechanisms