Oral stem cells, decoding and mapping the resident cells populations
Status PubMed-not-MEDLINE Jazyk angličtina Země Čína Médium electronic-ecollection
Typ dokumentu časopisecké články, přehledy
PubMed
35837342
PubMed Central
PMC9255788
DOI
10.12336/biomatertransl.2022.01.004
Knihovny.cz E-zdroje
- Klíčová slova
- dental pulp stem cells, dental stem cells, gingival stem cells, periodontal ligament stem cells, stem cells from apical papilla,
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The teeth and their supporting tissues provide an easily accessible source of oral stem cells. These different stem cell populations have been extensively studied for their properties, such as high plasticity and clonogenicity, expressing stem cell markers and potency for multilineage differentiation in vitro. Such cells with stem cell properties have been derived and characterised from the dental pulp tissue, the apical papilla region of roots in development, as well as the supporting tissue of periodontal ligament that anchors the tooth within the alveolar socket and the soft gingival tissue. Studying the dental pulp stem cell populations in a continuously growing mouse incisor model, as a traceable in vivo model, enables the researchers to study the properties, origin and behaviour of mesenchymal stem cells. On the other side, the oral mucosa with its remarkable scarless wound healing phenotype, offers a model to study a well-coordinated system of healing because of coordinated actions between epithelial, mesenchymal and immune cells populations. Although described as homogeneous cell populations following their in vitro expansion, the increasing application of approaches that allow tracing of individual cells over time, along with single-cell RNA-sequencing, reveal that different oral stem cells are indeed diverse populations and there is a highly organised map of cell populations according to their location in resident tissues, elucidating diverse stem cell niches within the oral tissues. This review covers the current knowledge of diverse oral stem cells, focusing on the new approaches in studying these cells. These approaches "decode" and "map" the resident cells populations of diverse oral tissues and contribute to a better understanding of the "stem cells niche architecture and interactions. Considering the high accessibility and simplicity in obtaining these diverse stem cells, the new findings offer potential in development of translational tissue engineering approaches and innovative therapeutic solutions.
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Nanci A. Ten Cate’s oral histology: development, structure, and function. 8th ed. Elsevier; St. Louis: 2012.
Gronthos S., Mankani M., Brahim J., Robey P. G., Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000;97:13625–13630. PubMed PMC
Gronthos S., Brahim J., Li W., Fisher L. W., Cherman N., Boyde A., DenBesten P., Robey P. G., Shi S. Stem cell properties of human dental pulp stem cells. J Dent Res. 2002;81:531–535. PubMed
Jo Y. Y., Lee H. J., Kook S. Y., Choung H. W., Park J. Y., Chung J. H., Choung Y. H., Kim E. S., Yang H. C., Choung P. H. Isolation and characterization of postnatal stem cells from human dental tissues. Tissue Eng. 2007;13:767–773. PubMed
Huang G. T., Gronthos S., Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res. 2009;88:792–806. PubMed PMC
Balic A., Aguila H. L., Caimano M. J., Francone V. P., Mina M. Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars. Bone. 2010;46:1639–1651. PubMed PMC
Volponi A. A., Pang Y., Sharpe P. T. Stem cell-based biological tooth repair and regeneration. Trends Cell Biol. 2010;20:715–722. PubMed PMC
Volponi A. A., Sharpe P. T. The tooth -- a treasure chest of stem cells. Br Dent J. 2013;215:353–358. PubMed
Angelova Volponi A., Zaugg L. K., Neves V., Liu Y., Sharpe P. T. Tooth repair and regeneration. Curr Oral Health Rep. 2018;5:295–303. PubMed PMC
Yelick P. C., Sharpe P. T. Tooth bioengineering and regenerative dentistry. J Dent Res. 2019;98:1173–1182. PubMed PMC
Smith A. J., Lesot H. Induction and regulation of crown dentinogenesis: embryonic events as a template for dental tissue repair? Crit Rev Oral Biol Med. 2001;12:425–437. PubMed
Smith J. G., Smith A. J., Shelton R. M., Cooper P. R. Recruitment of dental pulp cells by dentine and pulp extracellular matrix components. Exp Cell Res. 2012;318:2397–2406. PubMed
Smith A. J., Cassidy N., Perry H., Bàgue-Kirn C., Ruch J. V., Lesot H. Reactionary dentinogenesis. Int J Dev Biol. 1995;39:273–280. PubMed
Couve E., Osorio R., Schmachtenberg O. Reactionary dentinogenesis and neuroimmune response in dental caries. J Dent Res. 2014;93:788–793. PubMed PMC
Teaford M. F., Smith M. M., Ferguson M. W. J. Development, function and evolution of teeth. Cambridge University Press; Cambridge: 2000.
Feng J., Mantesso A., De Bari C., Nishiyama A., Sharpe P. T. Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proc Natl Acad Sci U S A. 2011;108:6503–6508. PubMed PMC
Vidovic I., Banerjee A., Fatahi R., Matthews B. G., Dyment N. A., Kalajzic I., Mina M. αSMA-expressing perivascular cells represent dental pulp progenitors in vivo. J Dent Res. 2017;96:323–330. PubMed PMC
Kaukua N., Shahidi M. K., Konstantinidou C., Dyachuk V., Kaucka M., Furlan A., An Z., Wang L., Hultman I., Ahrlund-Richter L., Blom H., Brismar H., Lopes N. A., Pachnis V., Suter U., Clevers H., Thesleff I., Sharpe P., Ernfors P., Fried K., Adameyko I. Glial origin of mesenchymal stem cells in a tooth model system. Nature. 2014;513:551–554. PubMed
Miura M., Gronthos S., Zhao M., Lu B., Fisher L. W., Robey P. G., Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003;100:5807–5812. PubMed PMC
Shi S., Bartold P. M., Miura M., Seo B. M., Robey P. G., Gronthos S. The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthod Craniofac Res. 2005;8:191–199. PubMed
Sakai V. T., Zhang Z., Dong Z., Neiva K. G., Machado M. A., Shi S., Santos C. F., Nör J. E. SHED differentiate into functional odontoblasts and endothelium. J Dent Res. 2010;89:791–796. PubMed
Cordeiro M. M., Dong Z., Kaneko T., Zhang Z., Miyazawa M., Shi S., Smith A. J., Nör J. E. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod. 2008;34:962–969. PubMed
Wang J., Wang X., Sun Z., Wang X., Yang H., Shi S., Wang S. Stem cells from human-exfoliated deciduous teeth can differentiate into dopaminergic neuron-like cells. Stem Cells Dev. 2010;19:1375–1383. PubMed PMC
Nakamura S., Yamada Y., Katagiri W., Sugito T., Ito K., Ueda M. Stem cell proliferation pathways comparison between human exfoliated deciduous teeth and dental pulp stem cells by gene expression profile from promising dental pulp. J Endod. 2009;35:1536–1542. PubMed
Laing A. G., Fanelli G., Ramirez-Valdez A., Lechler R. I., Lombardi G., Sharpe P. T. Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress. PLoS One. 2019;14:e0213170. PubMed PMC
Laing A. G., Riffo-Vasquez Y., Sharif-Paghaleh E., Lombardi G., Sharpe P. T. Immune modulation by apoptotic dental pulp stem cells in vivo. Immunotherapy. 2018;10:201–211. PubMed PMC
Gazarian K. G., Ramírez-García L. R. Human deciduous teeth stem cells (SHED) display neural crest signature characters. PLoS One. 2017;12:e0170321. PubMed PMC
Huang G. T., Sonoyama W., Liu Y., Liu H., Wang S., Shi S. The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering. J Endod. 2008;34:645–651. PubMed PMC
Sonoyama W., Liu Y., Yamaza T., Tuan R. S., Wang S., Shi S., Huang G. T. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod. 2008;34:166–171. PubMed PMC
Hilkens P., Bronckaers A., Ratajczak J., Gervois P., Wolfs E., Lambrichts I. The angiogenic potential of DPSCs and SCAPs in an in vivo model of dental pulp regeneration. Stem Cells Int. 2017;2017:2582080. PubMed PMC
Liu C., Xiong H., Chen K., Huang Y., Huang Y., Yin X. Long-term exposure to pro-inflammatory cytokines inhibits the osteogenic/ dentinogenic differentiation of stem cells from the apical papilla. Int Endod J. 2016;49:950–959. PubMed
Chen H., Fu H., Wu X., Duan Y., Zhang S., Hu H., Liao Y., Wang T., Yang Y., Chen G., Li Z., Tian W. Regeneration of pulpo-dentinal-like complex by a group of unique multipotent CD24a(+) stem cells. Sci Adv. 2020;6:eaay1514. PubMed PMC
Nada O. A., El Backly R. M. Stem cells from the apical papilla (SCAP) as a tool for endogenous tissue regeneration. Front Bioeng Biotechnol. 2018;6:103. PubMed PMC
Jeon B. G., Kang E. J., Kumar B. M., Maeng G. H., Ock S. A., Kwack D. O., Park B. W., Rho G. J. Comparative analysis of telomere length, telomerase and reverse transcriptase activity in human dental stem cells. Cell Transplant. 2011;20:1693–1705. PubMed
Volponi A. A., Gentleman E., Fatscher R., Pang Y. W., Gentleman M. M., Sharpe P. T. Composition of mineral produced by dental mesenchymal stem cells. J Dent Res. 2015;94:1568–1574. PubMed PMC
Bakopoulou A., Kritis A., Andreadis D., Papachristou E., Leyhausen G., Koidis P., Geurtsen W., Tsiftsoglou A. Angiogenic potential and secretome of human apical papilla mesenchymal stem cells in various stress microenvironments. Stem Cells Dev. 2015;24:2496–2512. PubMed PMC
Yu S., Zhao Y., Ma Y., Ge L. Profiling the secretome of human stem cells from dental apical papilla. Stem Cells Dev. 2016;25:499–508. PubMed
Diogenes A., Hargreaves K. M. Microbial modulation of stem cells and future directions in regenerative endodontics. J Endod. 2017;43:S95–S101. PubMed
Yi B., Ding T., Jiang S., Gong T., Chopra H., Sha O., Dissanayaka W. L., Ge S., Zhang C. Conversion of stem cells from apical papilla into endothelial cells by small molecules and growth factors. Stem Cell Res Ther. 2021;12:266. PubMed PMC
Pereira D., Sequeira I. A scarless healing tale: comparing homeostasis and wound healing of oral mucosa with skin and oesophagus. Front Cell Dev Biol. 2021;9:682143. PubMed PMC
Lindhe J., Lang N. P., Karring T. Clinical periodontology and implant dentistry. 5th ed. Wiley-Blackwell; 2008.
Zhang Q., Shi S., Liu Y., Uyanne J., Shi Y., Shi S., Le A. D. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol. 2009;183:7787–7798. PubMed PMC
Yang H., Gao L. N., An Y., Hu C. H., Jin F., Zhou J., Jin Y., Chen F. M. Comparison of mesenchymal stem cells derived from gingival tissue and periodontal ligament in different incubation conditions. Biomaterials. 2013;34:7033–7047. PubMed
Nakamura T., Inatomi T., Sotozono C., Amemiya T., Kanamura N., Kinoshita S. Transplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders. Br J Ophthalmol. 2004;88:1280–1284. PubMed PMC
Nakamura T., Takeda K., Inatomi T., Sotozono C., Kinoshita S. Long-term results of autologous cultivated oral mucosal epithelial transplantation in the scar phase of severe ocular surface disorders. Br J Ophthalmol. 2011;95:942–946. PubMed
Nagata M., Chu A. K. Y., Ono N., Welch J. D., Ono W. Single-cell transcriptomic analysis reveals developmental relationships and specific markers of mouse periodontium cellular subsets. Front Dent Med. 2021;2:679937. PubMed PMC
Wada N., Menicanin D., Shi S., Bartold P. M., Gronthos S. Immunomodulatory properties of human periodontal ligament stem cells. J Cell Physiol. 2009;219:667–676. PubMed
Zhao J., Volponi A. A., Caetano A., Sharpe P. T. Encyclopedia of Bone Biology. Elsevier; 2020. Mesenchymal stem cells in teeth; pp. 109–118.
Iwasaki K., Komaki M., Yokoyama N., Tanaka Y., Taki A., Kimura Y., Takeda M., Oda S., Izumi Y., Morita I. Periodontal ligament stem cells possess the characteristics of pericytes. J Periodontol. 2013;84:1425–1433. PubMed
Caetano A. J., Yianni V., Volponi A., Booth V., D’Agostino E. M., Sharpe P. Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease. eLife. 2021;10:e62810. PubMed PMC
Human cell atlas. https://www.humancellatlas.org/. Access March 1.2022.
An Z., Sabalic M., Bloomquist R. F., Fowler T. E., Streelman T., Sharpe P. T. A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors. Nat Commun. 2018;9:378. PubMed PMC
An Z., Akily B., Sabalic M., Zong G., Chai Y., Sharpe P. T. Regulation of mesenchymal stem to transit-amplifying cell transition in the continuously growing mouse incisor. Cell Rep. 2018;23:3102–3111. PubMed PMC
Seidel K., Marangoni P., Tang C., Houshmand B., Du W., Maas R. L., Murray S., Oldham M. C., Klein O. D. Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis. eLife. 2017;6:e24712. PubMed PMC
Krivanek J., Soldatov R. A., Kastriti M. E., Chontorotzea T., Herdina A. N., Petersen J., Szarowska B., Landova M., Matejova V. K., Holla L. I., Kuchler U., Zdrilic I. V., Vijaykumar A., Balic A., Marangoni P., Klein O. D., Neves V. C. M., Yianni V., Sharpe P. T., Harkany T., Metscher B. D., Bajénoff M., Mina M., Fried K., Kharchenko P. V., Adameyko I. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nat Commun. 2020;11:4816. PubMed PMC
Yu T., Volponi A. A., Babb R., An Z., Sharpe P. T. Stem cells in tooth development, growth, repair, and regeneration. Curr Top Dev Biol. 2015;115:187–212. PubMed
Zhao J., Faure L., Adameyko I., Sharpe P. T. Stem cell contributions to cementoblast differentiation in healthy periodontal ligament and periodontitis. Stem Cells. 2021;39:92–102. PubMed