MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review
PubMed
35961438
DOI
10.1016/j.gene.2022.146791
PII: S0378-1119(22)00610-2
Knihovny.cz E-resources
- Keywords
- Biomarker, Colorectal cancer, MALAT1, ceRNA, lncRNA,
- MeSH
- Biomarkers MeSH
- Colorectal Neoplasms * diagnosis genetics pathology MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Prognosis MeSH
- RNA, Long Noncoding genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Biomarkers MeSH
- MALAT1 long non-coding RNA, human MeSH Browser
- RNA, Long Noncoding MeSH
Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1), originally described as a prognostic biomarker remarkably linked with metastasis potential in lung cancer, has been identified as contributing to many diseases, including colorectal cancer (CRC). This long non-coding RNA (lncRNA) has come to the forefront of lncRNA research for its implications in cancer-related processes, such as cell proliferation and migration. In general, lncRNAs are recognized as enhancers, scaffolds, or decoys for a variety of oncogenes and tumor suppressors, although our understanding of lncRNA functions and mechanisms of action is still limited. Nowadays, cancer research is attracted to lncRNAs' ability to improve the early diagnosis of cancer, determine patients' prognosis, or predict therapy outcomes. In this review, we aimed to evaluate recent publications trying to uncover the cellular mechanisms of MALAT1-mediated regulation, and its potential exploitation in the management of CRC. The conclusions of this review provide robust support for the essential role of MALAT1 in CRC development and future personalized therapy.
References provided by Crossref.org
MALAT1 in Liquid Biopsy: The Diagnostic and Prognostic Promise for Colorectal Cancer and Adenomas?
