Automatic oxygen control for reducing extremes of oxygen saturation: a randomised controlled trial
Language English Country Great Britain, England Media print-electronic
Document type Randomized Controlled Trial, Journal Article
PubMed
35999043
DOI
10.1136/archdischild-2022-324160
PII: archdischild-2022-324160
Knihovny.cz E-resources
- Keywords
- Intensive Care Units, Neonatal, Neonatology,
- MeSH
- Hypoxia prevention & control MeSH
- Oxygen * MeSH
- Humans MeSH
- Infant, Premature * MeSH
- Infant, Newborn MeSH
- Oxygen Saturation MeSH
- Continuous Positive Airway Pressure MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Publication type
- Journal Article MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Oxygen * MeSH
OBJECTIVE: The objective of this study was to evaluate the efficacy of the automatic oxygen control (A-Fio2) in reducing the percentage of time spent in severe hypoxaemia (Spo2 <80%) in preterm infants for the time period on invasive ventilation and/or nasal continuous positive airway pressure (NCPAP) delivered by AVEA ventilator. DESIGN: A parallel arm randomised controlled trial. SETTING: A level-III neonatal intensive care unit. PATIENTS: Preterm infants (<33 weeks birth gestation) who received invasive ventilation or NCPAP in the first 72 hours of age. INTERVENTIONS: A-Fio2 vs manual (M-Fio2) oxygen control. OUTCOMES: The primary outcome of the study was percentage of time spent in severe hypoxaemia (Spo2 <80%). RESULTS: 44 infants were randomised to either A-Fio2 or M-Fio2 arm and continued in the study for the period of respiratory support (invasive ventilation and/or NCPAP). The total number of study days in A-Fio2 and M-Fio2 arm were 194 and 204 days, respectively. The percentage of time spent in Spo2 <80% was significantly lower with A-Fio2 compared with M-Fio2 (median of 0.1% (IQR: 0.07-0.7) vs 0.6% (0.2-2); p=0.03). The number of prolonged episodes (>60 s) of Spo2 <80% per day was also significantly lower in A-Fio2 (0.3 (0.0-2) vs 2 (0.6-6); p=0.02). CONCLUSION: A-Fio2 was associated with statistically significant reduction in the percentage of time spent in severe hypoxaemia when compared with M-Fio2 in preterm infants receiving respiratory support. TRIAL REGISTRATION NUMBER: NCT04223258.
Biomedical Engineering Czech Technical University Prague Praha Czech Republic
Neonatal Intensive Care Unit James Cook University Hospital Middlesbrough UK
Neonatology James Cook University Hospital Middlesbrough UK
Paediatric Respiratory Medicine Great North Children's Hospital Newcastle Upon Tyne UK
Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK
References provided by Crossref.org
ClinicalTrials.gov
NCT04223258
