Following the report of a non-travel-associated cluster of monkeypox cases by the United Kingdom in May 2022, 41 countries across the WHO European Region have reported 21,098 cases and two deaths by 23 August 2022. Nowcasting suggests a plateauing in case notifications. Most cases (97%) are MSM, with atypical rash-illness presentation. Spread is mainly through close contact during sexual activities. Few cases are reported among women and children. Targeted interventions of at-risk groups are needed to stop further transmission.

Austrian Agency for Health and Food Safety Vienna Austria

Centre for Health Security and Communicable Disease Control The Directorate of Health Reykjavik Iceland

Communicable Disease Surveillance Centre Public Health Wales Cardiff United Kingdom

Communicable Diseases Centre National Institute of Public Health Ljubljana Slovenia

Coordinating Centre for Health Alerts and Emergencies Directorate General of Public Health Ministry of Health Madrid Spain

Croatian Institute of Public Health Zagreb Croatia

Department for Infectious Disease Epidemiology Robert Koch Institute Berlin Germany

Department of Communicable Disease Epidemiology and Infection Control National Public Health Center Budapest Hungary

Department of Communicable Diseases Health Board Tallinn Estonia

Department of Infectious Disease Epidemiology and Prevention Statens Serum Institut Copenhagen Denmark

Department of Infectious Diseases Epidemiology National Institute of Public Health Prague Czech Republic

Department of Microbiological Reference Laboratory National Public Health Center Budapest Hungary

Department of Virus and Microbiological Special Diagnostics Statens Serum Institut Copenhagen Denmark

Directorate General of Health Prevention Ministry of Health Rome Italy

Directorate of Epidemiological Surveillance and Intervention for Infectious Diseases Hellenic National Public Health Organization Athens Greece

Directorate of Information and Analysis Directorate General of Health Lisbon Portugal

Division of Epidemiology Public Health Services Ministry of Health Jerusalem Israel

ECDC Fellowship Programme Field Epidemiology path Solna Sweden

Emerging Infectious Diseases Unit Department of Infectious Diseases Centro Hospitalar Universitário de São João Porto Portugal

European Centre for Disease Prevention and Control Solna Sweden

Field Services United Kingdom Health Security Agency London United Kingdom

Global Outbreak Alert and Response Network Geneva Switzerland

Head of Public Health Emergency Preparedness and Response Division National Center for Disease Control and Public Health Tbilisi Georgia

Health Directorate Luxembourg Luxembourg

Health Services Executive Health Protection Surveillance Centre Dublin Ireland

Infectious Disease Control and Vaccinations Unit Department of Health Security Finnish Institute for Health and Welfare Helsinki Finland

Infectious Disease Prevention and Control Unit Department of Infectious Risks Analysis and Prevention Centre for Disease Prevention and Control of Latvia Riga Latvia

Laboratory for Integrative and Translational Research in Population Health and EPIUnit Institute of Public Health University of Porto Porto Portugal

Ministry of Health Government of Andorra Andorra la Vella Andorra

National Centre of Epidemiology Carlos 3 Health Institute CIBER in Infectious Diseases Madrid Spain

National Centre of Surveillance and Control of Communicable Disease National Institute of Public Health Romania Bucharest Romania

National Institute for Public Health and the Environment Bilthoven the Netherlands

National Institute of Public Health National Research Institute Warsaw Poland

National Program for Sexually Transmitted Infections and HIV Infection Directorate General of Health Lisbon Portugal

Outbreak Research Team Institute of Tropical Medicine Antwerp Belgium

Public Health Scotland Edinburgh Scotland United Kingdom

Public Health Service of Amsterdam Amsterdam the Netherlands

Public Health Services Ministry of Health Jerusalem Israel

Public Health Wales Cardiff United Kingdom

Santé publique France Regional Office Saint Denis Île de France France

Santé publique France the French National Public Health Agency Saint Maurice France

School of Health Sciences Ashkelon Academic College Ashkelon Israel

Surveillance Coordination Department Hellenic National Public Health Organization Athens Greece

The Norwegian Institute of Public Health Oslo Norway

Unit for Diagnostics Preparedness of Notifiable and High Consequence Pathogens Public Health Agency of Sweden Solna Sweden

World Health Organization Regional Office for Europe Copenhagen Denmark

Zobrazit více v PubMed

World Health Organization (WHO). 2022 Monkeypox Outbreak: Global Trends. Geneva: WHO. [Accessed: 5 Sep 2022]. Available from: https://worldhealthorg.shinyapps.io/mpx_global

World Health Organization (WHO). Second meeting of the International Health Regulations (2005) (IHR) Emergency Committee regarding the multi-country outbreak of monkeypox. Geneva: WHO; 2022. Accessed: Available from: https://www.who.int/news/item/23-07-2022-second-meeting-of-the-international-health-regulations-(2005)-(ihr)-emergency-committee-regarding-the-multi-country-outbreak-of-monkeypox

United Kingdom Health Security Agency (UKHSA). Monkeypox cases confirmed in England – latest updates. London: UKHSA; 2022. Available from: https://www.gov.uk/government/news/monkeypox-cases-confirmed-in-england-latest-updates

Vivancos R, Anderson C, Blomquist P, Balasegaram S, Bell A, Bishop L, et al. Community transmission of monkeypox in the United Kingdom, April to May 2022. Euro Surveill. 2022;27(22):2200422. 10.2807/1560-7917.ES.2022.27.22.2200422 PubMed DOI PMC

World Health Organization (WHO). Monkeypox outbreak toolbox. Geneva: WHO; Jun 2022. Available from: https://www.who.int/emergencies/outbreak-toolkit/disease-outbreak-toolboxes/monkeypox-outbreak-toolbox

European Centre for Disease Control and Prevention (ECDC). Monkeypox multi-country outbreak. Stockholm: ECDC; 2022. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/Monkeypox-multi-country-outbreak.pdf

van de Kassteele J, Eilers PHC, Wallinga J. Nowcasting the number of new symptomatic cases during infectious disease outbreaks using constrained P-spline smoothing. Epidemiology. 2019;30(5):737-45. 10.1097/EDE.0000000000001050 PubMed DOI PMC

Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, et al. The changing epidemiology of human monkeypox-A potential threat? A systematic review. PLoS Negl Trop Dis. 2022;16(2):e0010141. 10.1371/journal.pntd.0010141 PubMed DOI PMC

Vaughan A, Aarons E, Astbury J, Balasegaram S, Beadsworth M, Beck CR, et al. Two cases of monkeypox imported to the United Kingdom, September 2018. Euro Surveill. 2018;23(38):1800509. 10.2807/1560-7917.ES.2018.23.38.1800509 PubMed DOI PMC

Durski KN, McCollum AM, Nakazawa Y, Petersen BW, Reynolds MG, Briand S, et al. Emergence of Monkeypox - West and Central Africa, 1970-2017. MMWR Morb Mortal Wkly Rep. 2018;67(10):306-10. 10.15585/mmwr.mm6710a5 PubMed DOI PMC

Vaughan A, Aarons E, Astbury J, Brooks T, Chand M, Flegg P, et al. Human-to-human transmission of monkeypox virus, United Kingdom, October 2018. Emerg Infect Dis. 2020;26(4):782-5. 10.3201/eid2604.191164 PubMed DOI PMC

Yong SEF, Ng OT, Ho ZJM, Mak TM, Marimuthu K, Vasoo S, et al. Imported Monkeypox, Singapore. Emerg Infect Dis. 2020;26(8):1826-30. 10.3201/eid2608.191387 PubMed DOI PMC

Reed KD, Melski JW, Graham MB, Regnery RL, Sotir MJ, Wegner MV, et al. The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med. 2004;350(4):342-50. 10.1056/NEJMoa032299 PubMed DOI

Erez N, Achdout H, Milrot E, Schwartz Y, Wiener-Well Y, Paran N, et al. Diagnosis of imported monkeypox, Israel, 2018. Emerg Infect Dis. 2019;25(5):980-3. 10.3201/eid2505.190076 PubMed DOI PMC

Hobson G, Adamson J, Adler H, Firth R, Gould S, Houlihan C, et al. Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom, May 2021. Euro Surveill. 2021;26(32):2100745. 10.2807/1560-7917.ES.2021.26.32.2100745 PubMed DOI PMC

Yinka-Ogunleye A, Aruna O, Dalhat M, Ogoina D, McCollum A, Disu Y, et al. Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report. Lancet Infect Dis. 2019;19(8):872-9. 10.1016/S1473-3099(19)30294-4 PubMed DOI PMC

Brown K, Leggat PA. Human Monkeypox: Current State of Knowledge and Implications for the Future. Trop Med Infect Dis. 2016;1(1):8. 10.3390/tropicalmed1010008 PubMed DOI PMC

Mbala PK, Huggins JW, Riu-Rovira T, Ahuka SM, Mulembakani P, Rimoin AW, et al. Maternal and Fetal Outcomes Among Pregnant Women With Human Monkeypox Infection in the Democratic Republic of Congo. J Infect Dis. 2017;216(7):824-8. 10.1093/infdis/jix260 PubMed DOI

World Health Organization (WHO). Factsheet: Monkeypox. Geneva: WHO; 19 May 2022. Available from: https://www.who.int/news-room/fact-sheets/detail/monkeypox

Heymann DL, Szczeniowski M, Esteves K. Re-emergence of monkeypox in Africa: a review of the past six years. Br Med Bull. 1998;54(3):693-702. 10.1093/oxfordjournals.bmb.a011720 PubMed DOI

Huhn GD, Bauer AM, Yorita K, Graham MB, Sejvar J, Likos A, et al. Clinical characteristics of human monkeypox, and risk factors for severe disease. Clin Infect Dis. 2005;41(12):1742-51. 10.1086/498115 PubMed DOI

Ježek Z, Szczeniowski M, Paluku KM, Mutombo M. Human monkeypox: clinical features of 282 patients. J Infect Dis. 1987;156(2):293-8. 10.1093/infdis/156.2.293 PubMed DOI

Fine PEM, Jezek Z, Grab B, Dixon H. The transmission potential of monkeypox virus in human populations. Int J Epidemiol. 1988;17(3):643-50. 10.1093/ije/17.3.643 PubMed DOI

Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, et al. Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022. N Engl J Med. 2022;387(8):679-91. 10.1056/NEJMoa2207323 PubMed DOI

Patel A, Bilinska J, Tam JCH, Da Silva Fontoura D, Mason CY, Daunt A, et al. Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series. BMJ. 2022;378:e072410. 10.1136/bmj-2022-072410 PubMed DOI PMC

Gobierno de Espana. Alerta sobre infección de viruela de los monos en España y otros países no endémicos. [Status report July 30, 2022. Alert on monkeypox infection in Spain and other non-endemic countries.] Centro de Coordinación de Alertas y Emergencias Sanitarias: Ministerio De Sanidad; 30 Jul 2022. Available from: https://www.sanidad.gob.es/profesionales/saludPublica/ccayes/alertasActual/alertaMonkeypox/docs/Informe_de_situacion_MPX_20220730.pdf

European Centre for Disease Prevention and Control (ECDC). Navigating monkeypox: considerations for gay and bisexual men and other men who have sex with men. Stockholm: ECDC. [Accessed: 10 Jun 2022]. Available from: https://www.ecdc.europa.eu/en/publications-data/navigating-monkeypox-considerations-gay-and-bisexual-men-and-msm

World Health Organization (WHO). Monkeypox: public health advice for gay, bisexual and other men who have sex with men. Geneva: WHO; 25 May 2022. Available from: https://www.who.int/news/item/25-05-2022-monkeypox--public-health-advice-for-gay--bisexual-and-other-men-who-have-sex-with-men

World Health Organization (WHO). Vaccines and immunization for monkeypox: Interim guidance. Geneva: WHO; 24 Aug 2022. Available from: https://apps.who.int/iris/bitstream/handle/10665/361894/WHO-MPX-Immunization-2022.2-eng.pdf

World Health Organization (WHO) Regional Office for Europe. Considerations for the control and elimination of monkeypox in the WHO European Region: policy brief No.1, 26 August 2022. Copenhagen: WHO Regional Office for Europe; 2022. Available from: https://apps.who.int/iris/handle/10665/361984

Continued circulation of mpox: an epidemiological and phylogenetic assessment, European Region, 2023 to 2024