Obesity in cases undergoing the surgical procedure of lung lobectomy: risk or benefit?
Jazyk angličtina Země Brazílie Médium print
Typ dokumentu časopisecké články
PubMed
36134838
PubMed Central
PMC9574992
DOI
10.1590/1806-9282.20220526
PII: S0104-42302022000801090
Knihovny.cz E-zdroje
- MeSH
- délka pobytu MeSH
- lidé MeSH
- nádory plic * chirurgie MeSH
- obezita etiologie MeSH
- plíce MeSH
- pneumektomie * škodlivé účinky metody MeSH
- pooperační komplikace etiologie MeSH
- retrospektivní studie MeSH
- torakotomie škodlivé účinky metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: The aim of the study was to evaluate the effect of body mass index on patients' short-term results following lung lobectomy. METHODS: In this retrospective study, we compared the perioperative and short-term postoperative results of obese (BMI≥30 kg/m2) versus non-obese patients (BMI<30 kg/m2) who underwent anatomical lung resection for cancer. The two groups had the same distribution of input risk factors and the same ratio of surgical approaches (thoracoscopy vs. thoracotomy). RESULTS: The study included a total of 144 patients: 48 obese and 96 non-obese patients. Both groups had the same ratio of thoracoscopic vs. thoracotomy approach (50/50%), and were comparable in terms of demographics and clinical data. The g roups did not significantly differ in the frequency of perioperative or postoperative complications. Postoperative morbidity was higher among non-obese patients (34.4 vs. 27.1%), but this difference was not statistically significant (p=0.053). Hospital stay was similar in both study groups (p=0.100). Surgery time was significantly longer among obese patients (p=0.133). Postoperative mortality was comparable between the study groups (p=0.167). CONCLUSIONS: Obesity does not increase the frequency of perioperative and postoperative complications in patients after lung lobectomy. The slightly better results in obese patients suggest that obesity may have some protective role.
Giresun University Faculty of Medicine Department of Pathology Giresun Turkey
Giresun University Faculty of Medicine Department of Surgery Giresun Turkey
Giresun University Faculty of Medicine Division of Endocrine Surgery Giresun Turkey
Tomas Bata University in Zlin Faculty of Humanities Zlin Czech Republic
University Hospital Ostrava Department of Surgery Ostrava Czech Republic
University of Ostrava Faculty of Medicine Department of Surgical Studies Ostrava Czech Republic
Zobrazit více v PubMed
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660. PubMed DOI
Israelsson LA, Jonsson T. Overweight and healing of midline incisions: the importance of suture technique. Eur J Surg. 1997;163(3):175–180. PubMed
Bamgbade OA, Rutter TW, Nafiu OO, Dorje P. Postoperative complications in obese and nonobese patients. World J Surg. 2007;31(3):556–560. doi: 10.1007/s00268-006-0305-0. PubMed DOI
Choban PS, Heckler R, Burge JC, Flancbaum L. Increased incidence of nosocomial infections in obese surgical patients. Am Surg. 1995;61(11):1001–1005. PubMed
Brandt M. Severe obesity does not adversely affect perioperative mortality and morbidity in coronary artery bypass surgery. Eur J Cardiothorac Surg. 2001;19(5):662–666. doi: 10.1016/s1010-7940(01)00647-9. PubMed DOI
Wigfield CH, Lindsey JD, Muñoz A, Chopra PS, Edwards NM, Love RB. Is extreme obesity a risk factor for cardiac surgery? An analysis of patients with a BMI≥40. Eur J Cardiothorac Surg. 2006;29(49):434–440. doi: 10.1016/j.ejcts.2006.01.016. PubMed DOI
Kuduvalli M, Grayson A, Oo A, Fabri B, Rashid A. Risk of morbidity and in-hospital mortality in obese patients undergoing coronary artery bypass surgery. Eur J Cardiothorac Surg. 2002;22(5):787–793. doi: 10.1016/s1010-7940(02)00448-7. PubMed DOI
Petrelli F, Cortellini A, Indini A, Tomasello G, Ghidini M, Nigro O, et al. Obesity paradox in patients with cancer: A systematic review and meta-analysis of 6,320,365 patients. MedRxiv. 2020 doi: 10.1101/2020.04.28.20082800. PubMed DOI
Seely AJ, Ivanovic J, Threader J, Al-Hussaini A, Al-Shehab DX, Ramsay T, et al. Systematic classification of morbidity and mortality after thoracic surgery. Ann Thorac Surg. 2010;90(3):936–942. doi: 10.1016/j.athoracsur.2010.05.014. PubMed DOI
Stamou SC, Nussbaum M, Stiegel RM, Reames MK, Skipper ER, Robicsek F, et al. Effect of body mass index on outcomes after cardiac surgery: is there an obesity paradox? Ann Thorac Surg. 2011;91:42–47. doi: 10.1016/j.athoracsur.2010.08.047. PubMed DOI
Le-Bert G, Santana O, Pineda AM, Zamora C, Lamas GA, Lamelas J. The obesity paradox in elderly obese patients undergoing coronary artery bypass surgery. Interact Cardiovasc Thorac Surg. 2011;13(2):124–127. doi: 10.1510/icvts.2010.256677. PubMed DOI
Levin NW, Handelman GJ, Coresh J, Port FK, Kaysen GA. Reverse epidemiology: a confusing, confounding, and inaccurate term. Semin Dial. 2007;20(6):586–592. doi: 10.1111/j.1525-139X.2007.00366.x. PubMed DOI
Fleischmann E, Teal N, Dudley J, May W, Bower JD, Salahudeen AK. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int. 1999;55(4):1560–1567. doi: 10.1046/j.1523-1755.1999.00389.x. PubMed DOI
Hainer V, Aldhoon-Hainerova I. Obesity paradox does exist. Diabetes Care. 2013;36(Suppl2):S276–S281. doi: 10.2337/dcS13-2023. PubMed DOI PMC
Wang L, Liu W, He X, Chen Y, Lu J, Liu K, et al. Association of overweight and obesity with patient mortality after acute myocardial infarction: a meta-analysis of prospective studies. Int J Obes (Lond) 2015;40(2):220–228. doi: 10.1038/ijo.2015.176. PubMed DOI
Gruberg L, Weissman NJ, Waksman R, Fuchs S, Deible R, Pinnow EE, et al. The impact of obesity on the short-term andlong-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol. 2002;39:578–584. doi: 10.1016/s0735-1097(01)01802-2. PubMed DOI
Vemmos K, Ntaios G, Spengos K, Savvari P, Vemmou A, Pappa T, et al. Association between obesity and mortality after acute first-ever stroke: the obesity-stroke paradox. Stroke. 2010;42(1):30–36. doi: 10.1161/STROKEAHA.110.593434. PubMed DOI
Julien JBS, Aldrich MC, Sheng S, Deppen SA, Burfeind WR, Jr, Putnam JB, et al. Obesity increases operating room time for lobectomy in the society of thoracic surgeons database. Ann Thorac Surg. 2012;94(6):1841–1847. doi: 10.1016/j.athoracsur.2012.08.006. PubMed DOI PMC
Onaitis MW, Petersen RP, Balderson SS, Toloza E, Burfeind WR, Harpole DH, Jr, et al. Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients. Ann Surg. 2006;244:420–425. doi: 10.1097/01.sla.0000234892.79056.63. PubMed DOI PMC
Paul S, Altorki NK, Sheng S, Lee PC, Harpole DH, Onaitis MW, et al. Thoracoscopic lobectomy is associated with lower morbidity than open lobectomy: a propensity-matched analysis from the STS database. J Thorac Cardiovasc Surg. 2010;139(2):366–378. doi: 10.1016/j.jtcvs.2009.08.026. PubMed DOI
Smith PW, Wang H, Gazoni LM, Shen KR, Daniel TM, Jones DR. Obesity does not increase complications after anatomic resection for non-small cell lung cancer. Ann Thorac Surg. 2007;84(4):1098–1106. doi: 10.1016/j.athoracsur.2007.04.033. PubMed DOI
Petrella F, Radice D, Borri A, Galetta D, Gasparri R, Solli P, et al. The impact of preoperative body mass index on respiratory complications after pneumonectomy for non-small-cell lung cancer. Results from a series of 154 consecutive standard pneumonectomies. Eur J Cardiothorac Surg. 2011;39(5):738–744. doi: 10.1016/j.ejcts.2010.09.007. PubMed DOI
Launer H, Nguyen DV, Cooke DT. National perioperative outcomes of pulmonary lobectomy for cancer in the obese patient: a propensity score matched analysis. J Thorac Cardiovasc Surg. 2013;145(5):1312–1318. doi: 10.1016/j.jtcvs.2012.10.012. PubMed DOI
Childers DK, Allison DB. The ‘obesity paradox’: a parsimonious explanation for relations among obesity, mortality rate and aging? Int J Obes. 2010;34(8):1231–1238. doi: 10.1038/ijo.2010.71. PubMed DOI PMC
Al-Ameri M, Bergman P, Franco-Cereceda A, Sartipy U. Video-assisted thoracoscopic versus open thoracotomy lobectomy: a Swedish nationwide cohort study. J Thorac Dis. 2018;10(6):3499–3506. doi: 10.21037/jtd.2018.05.177. PubMed DOI PMC