Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.

BIOCEV 1st Faculty of Medicine Charles University Prumyslova 595 25250 Vestec Czech Republic

Department of Chemical and Biomolecular Engineering Yonsei University 50 Yonsei ro Seodaemun gu Seoul 03722 Korea

Department of Chemistry and Biochemistry Mendel University Zemedelska 1 61300 Brno Czech Republic

Department of Medical Research China Medical University Hospital China Medical University No 91 Hsueh Shih Road 40402 Taichung Taiwan

Department of Pathological Physiology Faculty of Medicine Masaryk University Kamenice 5 62500 Brno Czech Republic

Department of Physiology Faculty of Medicine Masaryk University Kamenice 5 62500 Brno Czech Republic

Faculty of Electrical Engineering and Computer Science VSB Technical University of Ostrava 17 listopadu 2172 15 70800 Ostrava Czech Republic

Future Energy and Innovation Laboratory Central European Institute of Technology Brno University of Technology Purkynova 123 61200 Brno Czech Republic

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