Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Cargo Transportation, Micromachines, Micromotors, Photocatalysis, Tumor Cells,
- MeSH
- Dendrites MeSH
- Photochemotherapy * MeSH
- Glutathione MeSH
- Humans MeSH
- Magnetic Fields MeSH
- Tumor Microenvironment MeSH
- Prostatic Neoplasms * drug therapy MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ferric oxide MeSH Browser
- Glutathione MeSH
Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.
BIOCEV 1st Faculty of Medicine Charles University Prumyslova 595 25250 Vestec Czech Republic
Department of Chemistry and Biochemistry Mendel University Zemedelska 1 61300 Brno Czech Republic
Department of Physiology Faculty of Medicine Masaryk University Kamenice 5 62500 Brno Czech Republic
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Reconfigurable self-assembly of photocatalytic magnetic microrobots for water purification
