Adult Neurogenesis in the Gut, Homeostatic Autoimmunity and Neurodegenerative Disease Biomarkers
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
36195285
DOI
10.1016/j.neuroscience.2022.09.019
PII: S0306-4522(22)00489-4
Knihovny.cz E-resources
- Keywords
- adult neurogenesis, autoimmunity, biomarkers, enteric nervous system, neurodegenerative disease, tau,
- MeSH
- Autoimmunity MeSH
- Biomarkers metabolism MeSH
- Child MeSH
- Humans MeSH
- Neurodegenerative Diseases * metabolism MeSH
- Neurogenesis physiology MeSH
- Enteric Nervous System * metabolism MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
Autoantibodies to neuronal antigens are viewed as potential biomarkers for neurodegenerative diseases. Increasing evidence, however, suggests a dissociation of the neurodegenerative process in the central nervous system and dynamics of neuronal proteins in peripheral circulation with the prevalence of a wide variety of immunoglobulins reactive to neuronal antigens reported also in the blood of healthy subjects, including children. Recently discovered physiological turnover of neurons in enteric nervous system with release of neuronal proteins in peripheral circulation may account for this conundrum and provide a new perspective on molecular biomarkers of neurodegenerative diseases and immunotherapy.
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