Fluorescein, eosin Y, and rose bengal are dyes used in clinical medicine and considered (photo-)chemically stable. Upon extensive irradiation with visible light in aqueous solutions, we found that these compounds release carbon monoxide (CO) - a bioactive gasotransmitter - in 40-100% yields along with the production of low-mass secondary photoproducts, such as phthalic and formic acids, in a multistep degradation process. Such photochemistry should be considered in applications of these dyes, and they could also be utilized as visible-light activatable CO-releasing molecules (photoCORMs) with biological implications.

4th Department of Internal Medicine General University Hospital Prague and 1st Faculty of Medicine Charles University Kateřinská 32 121 08 Praha 2 Czech Republic

Department of Chemistry Faculty of Science Masaryk University Kamenice 735 5 A08 625 00 Brno Bohunice Czech Republic

Department of Organic Chemistry Faculty of Science Charles University Hlavova 2030 8 128 43 Prague Czech Republic

Institute of Medical Biochemistry and Laboratory Diagnostics General University Hospital Prague and 1st Faculty of Medicine Charles University Kateřinská 32 121 08 Praha 2 Czech Republic

RECETOX Faculty of Science Masaryk University Kamenice 735 5 D29 625 00 Brno Bohunice Czech Republic

Transport Research Centre Líšeňská 33a 636 00 Brno Líšeň Czech Republic

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