Common xanthene fluorescent dyes are visible-light activatable CO-releasing molecules
Language English Country England, Great Britain Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
36326159
DOI
10.1039/d2ob01823c
Knihovny.cz E-resources
- MeSH
- Rose Bengal MeSH
- Fluorescein MeSH
- Fluorescent Dyes * chemistry MeSH
- Light MeSH
- Xanthenes * chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Rose Bengal MeSH
- Fluorescein MeSH
- Fluorescent Dyes * MeSH
- Xanthenes * MeSH
Fluorescein, eosin Y, and rose bengal are dyes used in clinical medicine and considered (photo-)chemically stable. Upon extensive irradiation with visible light in aqueous solutions, we found that these compounds release carbon monoxide (CO) - a bioactive gasotransmitter - in 40-100% yields along with the production of low-mass secondary photoproducts, such as phthalic and formic acids, in a multistep degradation process. Such photochemistry should be considered in applications of these dyes, and they could also be utilized as visible-light activatable CO-releasing molecules (photoCORMs) with biological implications.
RECETOX Faculty of Science Masaryk University Kamenice 735 5 D29 625 00 Brno Bohunice Czech Republic
Transport Research Centre Líšeňská 33a 636 00 Brno Líšeň Czech Republic
References provided by Crossref.org
Antiproliferative and Cytotoxic Activities of Fluorescein-A Diagnostic Angiography Dye
