Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population
Language English Country Switzerland Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
36360218
PubMed Central
PMC9690213
DOI
10.3390/genes13111981
PII: genes13111981
Knihovny.cz E-resources
- Keywords
- age, angiotensinogen, coronary artery disease, restenosis, rs7079,
- MeSH
- 3' Untranslated Regions MeSH
- Angiotensinogen genetics MeSH
- Humans MeSH
- MicroRNAs * genetics metabolism MeSH
- Coronary Artery Disease * genetics MeSH
- Polymorphism, Genetic MeSH
- Binding Sites MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 3' Untranslated Regions MeSH
- AGT protein, human MeSH Browser
- Angiotensinogen MeSH
- MicroRNAs * MeSH
- MIRN31 microRNA, human MeSH Browser
Angiotensinogen (AGT) represents a key component of the renin-angiotensin-aldosterone system (RAAS). Polymorphisms in the 3' untranslated region (3'UTR) of the AGT gene may alter miRNA binding and cause disbalance in the RAAS. Within this study, we evaluated the possible association of AGT +11525C/A (rs7079) with the clinical characteristics of patients with coronary artery diseases (CAD). Selective coronarography was performed in 652 consecutive CAD patients. Clinical characteristics of the patients, together with peripheral blood samples for DNA isolation, were collected. The genotyping of rs7079 polymorphism was performed with TaqMan® SNP Genotyping Assays. We observed that patients with the CC genotype were referred for coronarography at a younger age compared to those with the AA+CA genotypes (CC vs. AA+CA: 59.1 ± 9.64 vs. 60.91 ± 9.5 (years), p = 0.045). Moreover, according to the logistic regression model, patients with the CC genotype presented more often with restenosis than those with the CA genotype (p = 0.0081). In conclusion, CC homozygotes for rs7079 present with CAD symptoms at a younger age compared with those with the AA+CA genotype, and they are more prone to present with restenosis compared with heterozygotes.
Department of Physiology Faculty of Medicine Masaryk University 625 00 Brno Czech Republic
International Clinical Research Center St Anne's University Hospital 656 91 Brno Czech Republic
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