OBJECTIVES: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown. METHODS: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results. RESULTS: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients. CONCLUSION: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.

Department of Biochemistry Cardiovascular Research Institute Maastricht Maastricht University Maastricht The Netherlands

Department of Internal Medicine Canisius Wilhelmina Hospital Nijmegen The Netherlands

Department of Internal Medicine University Hospital of Pilsen Pilsen Czech Republic

Department of Pulmonary Medicine Canisius Wilhelmina Hospital Nijmegen The Netherlands

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