Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26016598
DOI
10.1038/jhh.2015.55
PII: jhh201555
Knihovny.cz E-zdroje
- MeSH
- analýza pulzové vlny MeSH
- biologické markery krev MeSH
- dospělí MeSH
- ELISA MeSH
- extracelulární matrix - proteiny krev MeSH
- fosforylace MeSH
- lidé středního věku MeSH
- lidé MeSH
- lineární modely MeSH
- logistické modely MeSH
- matrixový protein Gla MeSH
- multivariační analýza MeSH
- nemoci aorty krev diagnóza patofyziologie MeSH
- odds ratio MeSH
- onemocnění periferních arterií krev diagnóza patofyziologie MeSH
- proteiny vázající vápník krev MeSH
- průřezové studie MeSH
- rizikové faktory MeSH
- senioři MeSH
- tuhost cévní stěny * MeSH
- upregulace MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- biologické markery MeSH
- extracelulární matrix - proteiny MeSH
- proteiny vázající vápník MeSH
Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and muscular-type large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P<0.0001) increased across the dp-ucMGP quartiles. After adjustment for all potential confounders, aortic PWV independently correlated with dp-ucMGP (with beta coefficient (s.d.) 11.61 (5.38) and P-value=0.031). In a categorized manner, subjects in the top quartile of dp-ucMGP (⩾ 671 pmol l(-1)) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.
Biomedical Centre Medical Faculty of Charles University Pilsen Czech Republic
Department of Immunodiagnostics University Hospital Pilsen Czech Republic
International Clinical Research Centre St Anne's University Hospital Brno Czech Republic
VitaK Cardiovascular Research Institute Maastricht University Maastricht The Netherlands
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