Patient-reported symptoms are a more reliable predictor of the societal burden compared to established physician-reported activity indices in inflammatory bowel disease: a cross-sectional study
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Crohn’s disease, absenteeism, out-of-pocket costs, presenteeism, productivity costs, ulcerative colitis,
- MeSH
- Crohnova nemoc * diagnóza MeSH
- hodnocení výsledků péče pacientem MeSH
- idiopatické střevní záněty * diagnóza MeSH
- lidé MeSH
- průřezové studie MeSH
- ulcerózní kolitida * diagnóza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: The societal burden of inflammatory bowel diseases (IBD) is not well documented, and further studies are needed to quantify the costs of the disease state. Thus, the aim was to estimate the societal burden and identify its predictors. METHODS: A cross-sectional questionnaire-based study complemented by objective data from patient medical records was performed for patients with Crohn's disease (CD) and ulcerative colitis (UC). RESULTS: We analyzed data from 161 patients (CD: 102, UC: 59). The overall work impairment reached 15.4%, 11.2% vs. 28.8% without/with self-reported symptoms (p = 0.006). Daily activity impairment was 19.3%, 14.1% vs. 35.6% (p < 0.001). The disability pension rate was 28%, 23% vs. 44% (p = 0.012). The total productivity loss due to absenteeism, presenteeism, and disability amounted to 7,673 €/patient/year, 6,018 vs. 12,354 €/patient/year (p = 0.000). Out-of-pocket costs amounted to 562 €/patient/year, 472 vs. 844 €/patient/year (p = 0.001). Self-reported symptoms were the strongest predictor of costs (p < 0.001). CONCLUSION: We found a high societal burden for IBD and a significant association between patient-reported disease symptoms and work disability, daily activity impairment, disability pensions, and out-of-pocket costs. Physician-reported disease activity is not a reliable predictor of costs except for out-of-pocket expenses.
Department of Medical Informatics 1st Faculty of Medicine Charles University Prague Czech Republic
Department of Pharmacology Faculty of Medicine Masaryk University Brno Czech Republic
Gastroenterology Department Ceske Budejovice Hospital Ceske Budejovice Czech Republic
IBD clinical and research center ISCARE a s Prague Czech Republic
Institute of Health Economics and Technology Assessment Prague Czech Republic
Institute of Pharmacology 1st Faculty of Medicine Charles University Prague Czech Republic
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