Multiple neurological effects associated with exposure to organophosphorus pesticides in man
Language English Country Ireland Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
36543276
DOI
10.1016/j.tox.2022.153407
PII: S0300-483X(22)00319-5
Knihovny.cz E-resources
- Keywords
- Acetylcholinesterase, Neurodegenerative diseases, Neurology, Neurotoxicity, Organophosphorus compounds, Toxicity,
- MeSH
- Attention Deficit Disorder with Hyperactivity * MeSH
- Humans MeSH
- Neurotoxicity Syndromes * etiology psychology MeSH
- Organophosphates toxicity MeSH
- Organophosphorus Compounds toxicity MeSH
- Pesticides * toxicity MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Organophosphates MeSH
- Organophosphorus Compounds MeSH
- Pesticides * MeSH
This article reviews available data regarding the possible association of organophosphorus (OP) pesticides with neurological disorders such as dementia, attention deficit hyperactivity disorder, neurodevelopment, autism, cognitive development, Parkinson's disease and chronic organophosphate-induced neuropsychiatric disorder. These effects mainly develop after repeated (chronic) human exposure to low doses of OP. In addition, three well defined neurotoxic effects in humans caused by single doses of OP compounds are discussed. Those effects are the cholinergic syndrome, the intermediate syndrome and organophosphate-induced delayed polyneuropathy. Usually, the poisoning can be avoided by an improved administrative control, limited access to OP pesticides, efficient measures of personal protection and education of OP pesticide applicators and medical staff.
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