• This ESMO–EURACAN Clinical Practice Guideline provides key recommendations for managing salivary gland cancer. • The guideline covers clinical and pathological diagnosis, staging and risk assessment, treatment and follow-up. • Treatment algorithms for parotid, submandibular, sublingual and minor salivary gland cancer are provided. • The author group encompasses a multidisciplinary group of experts from different institutions and countries in Europe. • Recommendations are based on available scientific data and the authors’ collective expert opinion.

Department of Head and Neck Oncology and Surgery Antoni van Leeuwenhoek Ziekenhuis and Amsterdam UMC Amsterdam

Department of Medical Oncology Radboud University Medical Center Nijmegen The Netherlands; Multidisciplinary Salivary Gland Society Geneva Switzerland https twitter com myESMO

Department of Otorhinolaryngology Head and Neck Surgery Erasmus University Medical Center Rotterdam The Netherlands

Department of Otorhinolaryngology Head and Neck Surgery Sorbonne Université Hôpital Tenon Assistance Publique Hôpitaux de Paris Paris France

Department of Pathology CHU Montpellier Montpellier France

Department of Pathology Radboud University Medical Center Nijmegen The Netherlands

Department of Radiology ASST Spedali Civili Brescia University of Brescia Brescia Italy

Evaluative Epidemiology Department of Research Fondazione IRCSS Istituto Nazionale dei Tumori Milan Italy

Faculty of Medicine Philipps University Marburg Marburg; Department of Radiation Oncology University Hospitals Gießen and Marburg Ltd Gießen Germany

Head and Neck Department Gustave Roussy Paris; French Network for Rare Head and Neck Cancers Paris France

Head and Neck Medical Oncology Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy

Multidisciplinary Salivary Gland Society Geneva Switzerland; Department of Oncology Section Head and Neck Oncology KU Leuven Leuven; Department of Otorhinolaryngology Head and Neck Surgery University Hospitals Leuven Leuven Belgium

Multidisciplinary Salivary Gland Society Geneva Switzerland; Department of Pathology Charles University Faculty of Medicine in Plzen Plzen Czech Republic

Multidisciplinary Salivary Gland Society Geneva Switzerland; Department of Radiotherapy University Medical Center Utrecht The Netherlands

Salivary Gland Cancer UK London UK

Service d'Oncologie Médicale Institut Roi Albert 2 Cliniques Universitaires Saint Luc Brussels; Institut de Recherche Clinique et Expérimentale Université Catholique de Louvain Brussels Belgium

Erratum In

ESMO Open. 2023 Oct;8(5):101630. doi: 10.1016/j.esmoop.2023.101630. PubMed

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