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PubMed

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The provisional OMERACT ultrasonography score for giant cell arteritis

Annals of the rheumatic diseases. 2023 Apr ; 82 (4) : 556-564. [epub] 20221212

Ann Rheum Dis
ISSN 1468-2060 | 0003-4967
Source

Language English Country United States Media print-electronic

Document type Journal Article

Persistent link https://www.medvik.cz/link/pmid36600183

PubMed 36600183
DOI 10.1136/ard-2022-223367
PII: S0003-4967(24)00442-4
Knihovny.cz E-resources

Keywords
giant cell arteritis, outcome assessment, health care, systemic vasculitis, ultrasonography,
MeSH
Temporal Arteries diagnostic imaging MeSH
Carotid Intima-Media Thickness MeSH
Humans MeSH
Giant Cell Arteritis * diagnostic imaging MeSH
Prospective Studies MeSH
Reproducibility of Results MeSH
Ultrasonography methods MeSH
Check Tag
Humans MeSH
Publication type
Journal Article MeSH

OBJECTIVES: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. METHODS: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. RESULTS: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). CONCLUSION: We developed a provisional OGUS for potential use in clinical trials.

Academic Rheumatology Center Dipartimento Scienze Cliniche e Biologiche Università degli Studi di Torino Turin Italy

Angiology University Hospital Basel Basel Switzerland

Arcispedale Santa Maria Nuova Reggio Emilia Italy

Center for Rheumatology and Spine Diseases Rigshospitalet Copenhagen Denmark

Centro Hospitalar do Baixo Vouga E P E Aveiro Portugal

Clinic for Rheumatology University Hospital Basel Basel Switzerland

Clinic of Internal Medicine 3 University Hospital Bonn Bonn Germany

Clinic of Rheumatology Medical University Plovdiv Plovdiv Bulgaria

Clinical Medicine Copenhagen University Copenhagen Denmark

Copenhagen Center for Arthritis Research Center for Rheumatology and Spine Diseases Rigshospitalet Glostrup Denmark

Department Clinical Medicine Aarhus University Aarhus Denmark

Department of Clinical Medicine Aarhus University Aarhus Denmark