Cancer is one of the leading causes of death worldwide, with nearly 10 million deaths in 2020 [...].

Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Faculty of Pharmacy in Hradec Králové Charles University Ak Heyrovského 1203 8 500 05 Hradec Králové Czech Republic

Laboratory for Machine Learning and Knowledge Representation Ruđer Bošković Institute Bijenička 54 10000 Zagreb Croatia

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World-Health-Organization Cancer. [(accessed on 11 January 2023)]. Available online: https://www.who.int/news-room/fact-sheets/detail/cancer.

Chok K.C., Koh R.Y., Ng M.G., Ng P.Y., Chye S.M. Melatonin Induces Autophagy via Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells. Molecules. 2021;26:17. doi: 10.3390/molecules26165038. PubMed DOI PMC

Lee C.W., Huang C.C.Y., Chi M.C., Lee K.H., Peng K.T., Fang M.L., Chiang Y.C., Liu J.F. Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines. Molecules. 2022;27:16. doi: 10.3390/molecules27020373. PubMed DOI PMC

Gomes D.A., Joubert A.M., Visagie M.H. In Vitro Effects of Papaverine on Cell Proliferation, Reactive Oxygen Species, and Cell Cycle Progression in Cancer Cells. Molecules. 2021;26:19. doi: 10.3390/molecules26216388. PubMed DOI PMC

Augusti P.R., Quatrin A., Mello R., Bochi V.C., Rodrigues E., Prazeres I.D., Macedo A.C., Oliveira-Alves S.C., Emanuelli T., Bronze M.R., et al. Antiproliferative Effect of Colonic Fermented Phenolic Compounds from Jaboticaba (Myrciaria trunciflora) Fruit Peel in a 3D Cell Model of Colorectal Cancer. Molecules. 2021;26:13. doi: 10.3390/molecules26154469. PubMed DOI PMC

He S.Y., Cui X.Y., Khan A., Liu Y.P., Wang Y.D., Cui Q.M., Zhao T.R., Cao J.X., Cheng G.G. Activity Guided Isolation of Phenolic Compositions from Anneslea fragrans Wall. and Their Cytoprotective Effect against Hydrogen Peroxide Induced Oxidative Stress in HepG2 Cells. Molecules. 2021;26:14. doi: 10.3390/molecules26123690. PubMed DOI PMC

Chai T.T., Koh J.A., Wong C.C.C., Sabri M.Z., Wong F.C. Computational Screening for the Anticancer Potential of Seed-Derived Antioxidant Peptides: A Cheminformatic Approach. Molecules. 2021;26:21. doi: 10.3390/molecules26237396. PubMed DOI PMC

Aliyev A.T., Panieri E., Stepanić V., Gurer-Orhan H., Saso L. Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin. Molecules. 2021;26:18. doi: 10.3390/molecules26071853. PubMed DOI PMC

Tawfik M.M., Eissa N., Althobaiti F., Fayad E., Abu Almaaty A.H. Nomad Jellyfish Rhopilema nomadica Venom Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Hepatocellular Carcinoma HepG2 Cells. Molecules. 2021;26:14. doi: 10.3390/molecules26175185. PubMed DOI PMC

Heymans V., Kunath S., Hajieva P., Moosmann B. Cell Culture Characterization of Prooxidative Chain-Transfer Agents as Novel Cytostatic Drugs. Molecules. 2021;26:12. doi: 10.3390/molecules26216743. PubMed DOI PMC

Sangweni N.F., Dludla P.V., Chellan N., Mabasa L., Sharma J.R., Johnson R. The Implication of Low Dose Dimethyl Sulfoxide on Mitochondrial Function and Oxidative Damage in Cultured Cardiac and Cancer Cells. Molecules. 2021;26:15. doi: 10.3390/molecules26237305. PubMed DOI PMC

Valiuliene G., Vitkeviciene A., Skliute G., Borutinskaite V., Navakauskiene R. Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling. Molecules. 2021;26:13. doi: 10.3390/molecules26082303. PubMed DOI PMC

Huntosova V., Horvath D., Seliga R., Wagnieres G. Influence of Oxidative Stress on Time-Resolved Oxygen Detection by Ru(Phen)(3) (2+) In Vivo and In Vitro. Molecules. 2021;26:24. doi: 10.3390/molecules26020485. PubMed DOI PMC

Ramirez-Palma L.G., Espinoza-Guillen A., Nieto-Camacho F., Lopez-Guerra A.E., Gomez-Vidales V., Cortes-Guzman F., Ruiz-Azuara L. Intermediate Detection in the Casiopeina-Cysteine Interaction Ending in the Disulfide Bond Formation and Copper Reduction. Molecules. 2021;26:12. doi: 10.3390/molecules26195729. PubMed DOI PMC

Augusto-Jimenez Y.E., Gonzalez-Montoya M., Naranjo-Feliciano D., Uribe-Ramirez D., Cristiani-Urbina E., Diaz-Aguila C., Yee-Madeira H., Mora-Escobedo R. Antioxidant Activity of Bioactive Peptide Fractions from Germinated Soybeans Conjugated to Fe3O4 Nanoparticles by the Ugi Multicomponent Reaction. Molecules. 2021;26:15. doi: 10.3390/molecules26195726. PubMed DOI PMC

Binatti E., Zoccatelli G., Zanoni F., Dona G., Mainente F., Chignola R. Effects of Combination Treatments with Astaxanthin-Loaded Microparticles and Pentoxifylline on Intracellular ROS and Radiosensitivity of J774A.1 Macrophages. Molecules. 2021;26:11. doi: 10.3390/molecules26175152. PubMed DOI PMC

Milković L., Čipak Gašparović A. AQP3 and AQP5-Potential Regulators of Redox Status in Breast Cancer. Molecules. 2021;26:14. doi: 10.3390/molecules26092613. PubMed DOI PMC

Stepanić V., Kučerová-Chlupáčová M. Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products. Molecules. 2023;28:475. doi: 10.3390/molecules28020475. PubMed DOI PMC

GdVO4:Eu3+ and LaVO4:Eu3+ Nanoparticles Exacerbate Oxidative Stress in L929 Cells: Potential Implications for Cancer Therapy