The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

3rd Radiotherapy and Chemotherapy Department Maria Skłodowska Curie National Research Institute of Oncology Ul Wybrzeze Armii Krajowej Gliwice 44102 Poland

Arrhythmia Unit Department of Cardiology Consorcio Hospital General Universitario de Valencia Av Tres Cruces 2 Valencia 46014 Spain

Arrhythmia Unit Department of Cardiology University Hospital Zurich Ramistrasse 71 Zurich 8006 Switzerland

Bioethics Unit Azienda Unità Sanitaria Locale IRCCS Via Amendola 2 Reggio Emilia 42100 Italy

Cardiac Intensive Care Unit Arrhythmia and Electrophysiology and Experimental Cardiology Fondazione IRCCS Policlinico San Matteo Camillo Golgi Avenue 5 Pavia 27100 Italy

Cardiocenter Hospital Agel Trinec Podlesi and Masaryk University Konska 453 Trinec 73961 Czech Republic

Cardiology Arrhythmology Center AUSL IRCCS di Reggio Emilia Via Amendola 2 Reggio Emilia 42100 Italy

Department for Radiation Oncology Charité Universitätsmedizin Berlin Charitéplatz 1 10117 Berlin Germany

Department of Advanced Radiation Oncology IRCCS Sacro Cuore Don Calabria Hospital University of Brescia Via San Zeno in Monte 23 Verona 37129 Italy

Department of Cardiology Aarhus University Hospital Palle Juul Jensens Boulevard 99 Aarhus 8200 Denmark

Department of Cardiology Amsterdam UMC University of Amsterdam Meibergdreef 15 Amsterdam 1105AZ The Netherlands

Department of Cardiology Catharina Hospital Michelangelolaan 2 Eindhoven 5623 EJ The Netherlands

Department of Cardiology Division of Heart and Lungs University Medical Center Utrecht Utrecht University Heidelberglaan 100 Utrecht 3584 CX The Netherlands

Department of Cardiology Hospital del Mar Universitat Pompeu Fabra Institut Hospital del Mar d'Investigacions Mèdiques Paseo Maritim 25 29 Barcelona 08003 Spain

Department of Cardiology Inselspital Bern University Hospital University of Bern Freiburgstrasse 18 Bern 3010 Switzerland

Department of Cardiology Institute for Clinical and Experimental Medicine Videnska 9 Prague 14000 Czech Republic

Department of Cardiology IRCCS Sacro Cuore Don Calabria Hospital Via San Zeno in Monte 23 Verona 37129 Italy

Department of Cardiology Maastricht University Medical Center P Debyelaan 25 Maastricht 6229 HX The Netherlands

Department of Cardiovascular Medicine University Hospital Ostrava Listopadu 1790 Ostrava Poruba 70852 Czech Republic

Department of Electrophysiology Heart Center Leipzig University of Leipzig Struempellstrasse 39 Leipzig 04289 Germany

Department of Medical Sciences University of Turin Via Verdi 8 Torino 10124 Italy

Department of Medicine 1 University Medical Center Mannheim Medical Faculty Mannheim University of Heidelberg Theodor Kutzer Ufer 1 3 Mannheim 68167 Germany

Department of Oncology Aarhus University Hospital Palle Juul Jensens Boulevard 99 Aarhus 8200 Denmark

Department of Oncology and Radiotherapy Faculty of Medicine Medical University of Gdansk M Sklodowskiel Curie 3a Gdansk 80210 Poland

Department of Oncology University Hospital and Faculty of Medicine Listopadu 1790 Ostrava Poruba 70852 Czech Republic

Department of Oncology University of Torino Via Giuseppe Verdi 8 Torino 10124 Italy

Department of Radiation Oncology Amsterdam UMC University of Amsterdam Meibergdreef 15 Amsterdam 1105AZ The Netherlands

Department of Radiation Oncology Catharina Hospital Michelangelolaan 2 Eindhoven 5623 EJ The Netherlands

Department of Radiation Oncology GROW School for Oncology and Reproduction Maastricht University Medical Centre P Debyelaan 25 Maastricht 6229 HX The Netherlands

Department of Radiation Oncology Hospital Clínico San Carlos Faculty of Medicine University Complutense of Madrid Profesor Martin Lagos Madrid 28040 Spain

Department of Radiation Oncology Hospital del Mar Universitat Pompeu Fabra Institut Hospital del Mar d'Investigacions Mèdiques Paseo Maritim 25 29 Barcelona 08003 Spain

Department of Radiation Oncology Hospital General Valencia Av Tres Cruces 2 Valencia 46014 Spain

Department of Radiation Oncology Inselspital Bern University Hospital University of Bern Freiburgstrasse 18 Bern 3010 Switzerland

Department of Radiation Oncology University Hospital of Zurich Ramistrasse 71 Zurich 8006 Switzerland

Department of Radiation Oncology University Medical Center Mannheim Medical Faculty Mannheim University of Heidelberg Theodor Kutzer Ufer 1 3 Mannheim 68167 Germany

Department of Radiation Oncology University Medical Center Schleswig Holstein Arnold Heller Strasse 3 Kiel 24105 Germany

Department of Radio Oncology Lausanne University Hospital Rue du Bugnon 21 Lausanne 1011 Switzerland

Department of Radiotherapy and Radiation Oncology Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universität Dresden Fetscherstraße 74 Dresden 01307 Germany

Department of Radiotherapy Maria Skłodowska Curie National Research Institute of Oncology Ul Wybrzeze Armii Krajowej Gliwice 44102 Poland

Department of Radiotherapy University Medical Center Utrecht Heidelberglaan 100 Utrecht 3584 CX The Netherlands

Department of Rhythmology Charité University Medicine Berlin Charitéplatz 1 10117 Berlin Germany

Division of Cardiology and Structural Heart Diseases Medical University of Silesia Ul Poniatowskiego 15 Katowice 40055 Poland

Division of Cardiology Cardiovascular and Thoracic Department 'Città della Salute e della Scienza' Hospital Via Giuseppe Verdi 8 Torino 10124 Italy

Electrophysiology Unit Department of Cardiology Hospital Clínico San Carlos Madrid Professor Martin Lagos Madrid 28040 Spain

Heart and Vessel Department Service of Cardiology Lausanne University Hospital and University of Lausanne Rue du Bugnon 21 Lausanne 1011 Switzerland

Institute of Radiooncology OncoRay Helmholtz Zentrum Dresden Rossendorf Bautzner Landstr 400 Dresden 01328 Germany

Interventional Cardiac Electrophysiology Group International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic

National Center of Oncological Hadrontherapy Strada Campeggi 53 Pavia PV27100 Italy

OncoRay National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universität Dresden Helmholtz Zentrum Dresden Rossendorf Fetscherstrasse 74 Dresden 01307 Germany

Radiation Oncology Unit Clinical Cancer Centre AUSL IRCCS di Reggio Emilia Via Amendola 2 Reggio Emilia 42100 Italy

Research Support Office University Medical Center Utrecht Heidelberglaan 100 Utrecht 3584 CX The Netherlands

Unit of Clinical Electrophysiology Leiden University Medical Center Albinusdreef 2 Leiden 2333 ZA The Netherlands

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