Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
34600851
DOI
10.1016/j.jacep.2021.07.012
PII: S2405-500X(21)00687-3
Knihovny.cz E-resources
- Keywords
- catheter ablation, histology, immunohistochemistry, radiotherapy, ventricular tachycardia,
- MeSH
- Catheter Ablation * MeSH
- Tachycardia, Ventricular * etiology surgery MeSH
- Humans MeSH
- Myocardium MeSH
- Radiosurgery * adverse effects MeSH
- Heart Ventricles surgery MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Stereotactic body radiotherapy (SBRT) has been suggested as a promising therapeutic alternative in cases of failed catheter ablation for recurrent ventricular tachycardias (VTs) in patients with structural heart disease. This case series is the first postmortem immunohistochemical analysis of morphologic changes in the myocardium early and late after SBRT. The present findings are in line with experimental observations on apoptosis followed by fibrosis. This may explain why the effect of SBRT on VT is not predominantly immediate. Together with observation of early recurrences after SBRT for VT, these data suggest that this strategy may have rather delayed antiarrhythmic effects.
Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic
Department of Oncology University Hospital Ostrava Ostrava Czech Republic
Department of Pathology Institute for Clinical and Experimental Medicine Prague Czech Republic
Masaryk University Brno Czech Republic; Agel Hospital Trinec Podlesi a s Trinec Czech Republic
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