Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
34600851
DOI
10.1016/j.jacep.2021.07.012
PII: S2405-500X(21)00687-3
Knihovny.cz E-zdroje
- Klíčová slova
- catheter ablation, histology, immunohistochemistry, radiotherapy, ventricular tachycardia,
- MeSH
- katetrizační ablace * MeSH
- komorová tachykardie * etiologie chirurgie MeSH
- lidé MeSH
- myokard MeSH
- radiochirurgie * škodlivé účinky MeSH
- srdeční komory chirurgie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Stereotactic body radiotherapy (SBRT) has been suggested as a promising therapeutic alternative in cases of failed catheter ablation for recurrent ventricular tachycardias (VTs) in patients with structural heart disease. This case series is the first postmortem immunohistochemical analysis of morphologic changes in the myocardium early and late after SBRT. The present findings are in line with experimental observations on apoptosis followed by fibrosis. This may explain why the effect of SBRT on VT is not predominantly immediate. Together with observation of early recurrences after SBRT for VT, these data suggest that this strategy may have rather delayed antiarrhythmic effects.
Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic
Department of Oncology University Hospital Ostrava Ostrava Czech Republic
Department of Pathology Institute for Clinical and Experimental Medicine Prague Czech Republic
Masaryk University Brno Czech Republic; Agel Hospital Trinec Podlesi a s Trinec Czech Republic
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