Bystander activation in memory and antigen-inexperienced memory-like CD8 T cells
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
36913776
DOI
10.1016/j.coi.2023.102299
PII: S0952-7915(23)00018-3
Knihovny.cz E-resources
- Keywords
- CD8, CD8+ T cells, IFNγ, IL-12, Memory T cells, NKG2D, antigen-inexperienced memory-like T cells, bystander response, innate-like lymphocytes,
- MeSH
- Lymphocyte Activation * MeSH
- Antigens MeSH
- CD8-Positive T-Lymphocytes * MeSH
- Cytokines MeSH
- Immunologic Memory MeSH
- Humans MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antigens MeSH
- Cytokines MeSH
Antigen-induced memory T cells undergo counterintuitive activation in an antigen-independent manner, which is called bystander response. Although it is well documented that memory CD8+ T cells produce IFNγ and upregulate the cytotoxic program upon the stimulation with inflammatory cytokines, there is only rare evidence that this provides an actual protection against pathogens in immunocompetent individuals. One of the reasons might be numerous antigen-inexperienced memory-like T cells that are also capable of the bystander response. Little is known about the bystander protection of memory and memory-like T cells and their redundancies with innate-like lymphocytes in humans because of the interspecies differences and the lack of controlled experiments. However, it has been proposed that IL-15/NKG2D-driven bystander activation of memory T cells drives protection or immunopathology in particular human diseases.
References provided by Crossref.org
IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy
