We describe a straightforward one-pot reductive protocol for the synthesis of sulfinamides from sulfonyl chlorides. This method enables the preparation of sulfinamides with a broad range of functional groups. Furthermore, we have expanded a known oxidative pathway to sulfinamides starting from thiols. These methods together provide a general strategy for the synthesis of sulfinamides from common sulfur-based feedstock that is available with large structural and functional group diversity.

Department of Organic Chemistry Faculty of Science Charles University Prague Hlavova 2030 8 12843 Prague 2 Czech Republic

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Sulfinamide Crossover Reaction