Disgust is an essential part of the behavioral immune system, protecting the individual from infection. According to the Compensatory Prophylaxis Hypothesis (CPH), disgust sensitivity increases in times of immunosuppression, potentially including pregnancy. We aimed to replicate a previous study observing longitudinal changes in disgust sensitivity in pregnant women. Additionally, for the first time, we explored how recent health problems influence these changes. To do this, we obtained disgust sensitivity measures from 94 women in each trimester and in early postpartum. In contrast to the original study, where disgust sensitivity was highest in the first trimester, we found that overall and animal reminder disgust increased across pregnancy and after birth. In line with the CPH, women who were recently sick in the first trimester had elevated disgust sensitivity at that time. Although disgust sensitivity was significantly higher in the second trimester and postpartum period compared to the first trimester in mothers pregnant with a male fetus, the overall results regarding the effect of fetus sex on disgust sensitivity were mixed. It seems that changing levels of disgust sensitivity during pregnancy and postpartum result from a suite of physiological and psychological changes that occur during this sensitive period of a woman's life.

Department of Philosophy and History of Science Faculty of Science Charles University Prague Czech Republic

Division of Psychology University of Stirling Stirling Scotland United Kingdom

ProfiGyn S R O Municipal Health Centre Prague Prague Czech Republic

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Curtis V, Aunger R, Rabie T. Evidence that disgust evolved to protect from risk of disease. Proc. R. Soc. Lond. B Biol. Sci. 2004;271:S131–S133. doi: 10.1098/rsbl.2003.0144. PubMed DOI PMC

Schaller, M. & Duncan, L. A. The behavioral immune system: Its evolution and social psychological implications. in Evolution and the social mind: Evolutionary psychology and social cognition (eds. J. P. Forgas, M. G. Haselton, & W. von Hippel) 293–307 (Routledge/Taylor & Francis Group, 2007).

Olatunji BO, et al. The Disgust scale: Item analysis, factor structure, and suggestions for refinement. Psychol. Assess. 2007;19:281–297. doi: 10.1037/1040-3590.19.3.281. PubMed DOI

Fessler DMT, Navarrete CD. Domain-specific variation in disgust sensitivity across the menstrual cycle. Evol. Hum. Behav. 2003;24:406–417. doi: 10.1016/S1090-5138(03)00054-0. DOI

Quigley JF, Sherman MF, Sherman NC. Personality disorder symptoms, gender, and age as predictors of adolescent disgust sensitivity. Personal. Individ. Differ. 1997;22:661–667. doi: 10.1016/S0191-8869(96)00255-3. DOI

Ding Y, Yang J, Ji T, Guo Y. Women suffered more emotional and life distress than men during the COVID-19 pandemic: The role of pathogen disgust sensitivity. Int. J. Environ. Res. Public. Health. 2021;18:8539. doi: 10.3390/ijerph18168539. PubMed DOI PMC

Hennig J, Pössel P, Netter P. Sensitivity to disgust as an indicator of neuroticism: A psychobiological approach. Personal. Individ. Differ. 1996;20:589–596. doi: 10.1016/0191-8869(95)00218-9. DOI

Cervin M, Perrin S, Olsson E, Claesdotter-Knutsson E, Lindvall M. Incompleteness, harm avoidance, and disgust: A comparison of youth with OCD, anxiety disorders, and no psychiatric disorder. J. Anxiety Disord. 2020;69:102175. doi: 10.1016/j.janxdis.2019.102175. PubMed DOI

Bayliss AP, Frischen A, Fenske MJ, Tipper SP. Affective evaluations of objects are influenced by observed gaze direction and emotional expression. Cognition. 2007;104:644–653. doi: 10.1016/j.cognition.2006.07.012. PubMed DOI

Milkowska K, Galbarczyk A, Jasienska G. Disgust sensitivity in relation to menstrual cycle phase in women with and without an infection. Am. J. Hum. Biol. 2019;31:e23233. doi: 10.1002/ajhb.23233. PubMed DOI

Stevenson RJ, Case TI, Oaten MJ. Frequency and recency of infection and their relationship with disgust and contamination sensitivity. Evol. Hum. Behav. 2009;30:363–368. doi: 10.1016/j.evolhumbehav.2009.02.005. DOI

Sarolidou G, et al. People expressing olfactory and visual cues of disease are less liked. Philos. Trans. R. Soc. B Biol. Sci. 2020;375:20190272. doi: 10.1098/rstb.2019.0272. PubMed DOI PMC

Skolnick AJ, Dzokoto VA. Disgust and contamination: A cross-national comparison of Ghana and the United States. Front. Psychol. 2013;4:91. doi: 10.3389/fpsyg.2013.00091. PubMed DOI PMC

Cepon-Robins TJ, et al. Pathogen disgust sensitivity protects against infection in a high pathogen environment. Proc. Natl. Acad. Sci. 2021;118:e2018552118. doi: 10.1073/pnas.2018552118. PubMed DOI PMC

de Barra M, Islam MS, Curtis V. Disgust sensitivity is not associated with health in a rural Bangladeshi sample. PLoS One. 2014;9:e100444. doi: 10.1371/journal.pone.0100444. PubMed DOI PMC

Oaten M, Stevenson R, Case T. Compensatory up-regulation of behavioral disease avoidance in immuno-compromised people with rheumatoid arthritis. Evol. Hum. Behav. 2016;38:350–356. doi: 10.1016/j.evolhumbehav.2016.11.006. DOI

Tybur JM, Jones BC, DeBruine LM, Ackerman JM, Fasolt V. Preregistered direct replication of “Sick body, vigilant mind: The biological immune system activates the behavioral immune system”. Psychol. Sci. 2020;31:1461–1469. doi: 10.1177/0956797620955209. PubMed DOI PMC

Miller SL, Maner JK. Sick body, vigilant mind: The biological immune system activates the behavioral immune system. Psychol. Sci. 2011;22:1467–1471. doi: 10.1177/0956797611420166. PubMed DOI

Fessler D. Luteal phase immunosuppression and meat eating. Riv. Biol. 2001;94:403–426. PubMed

Fleischman DS, Fessler DMT. Progesterone’s effects on the psychology of disease avoidance: Support for the compensatory behavioral prophylaxis hypothesis. Horm. Behav. 2011;59:271–275. doi: 10.1016/j.yhbeh.2010.11.014. PubMed DOI

Żelaźniewicz A, Borkowska B, Nowak J, Pawłowski B. The progesterone level, leukocyte count and disgust sensitivity across the menstrual cycle. Physiol. Behav. 2016;161:60–65. doi: 10.1016/j.physbeh.2016.04.002. PubMed DOI

Jones BC, et al. Hormonal correlates of pathogen disgust: Testing the compensatory prophylaxis hypothesis. Evol. Hum. Behav. 2018;39:166–169. doi: 10.1016/j.evolhumbehav.2017.12.004. DOI

Fessler DMT, Eng SJ, Navarrete CD. Elevated disgust sensitivity in the first trimester of pregnancy. Evol. Hum. Behav. 2005;26:344–351. doi: 10.1016/j.evolhumbehav.2004.12.001. DOI

Racicot K, Kwon J-Y, Aldo P, Silasi M, Mor G. Understanding the complexity of the immune system during pregnancy. Am. J. Reprod. Immunol. 2014;72:107–116. doi: 10.1111/aji.12289. PubMed DOI PMC

Folstad I, Karter AJ. Parasites, bright males, and the immunocompetence handicap. Am. Nat. 1992;139:603–622. doi: 10.1086/285346. DOI

Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 2000;21:55–89. PubMed

DiPietro JA, Costigan KA, Kivlighan KT, Chen P, Laudenslager ML. Maternal salivary cortisol differs by fetal sex during the second half of pregnancy. Psychoneuroendocrinology. 2011;36:588–591. doi: 10.1016/j.psyneuen.2010.09.005. PubMed DOI PMC

Meulenberg PMM, Hofman JA. Maternal testosterone and fetal sex. J. Steroid Biochem. Mol. Biol. 1991;39:51–54. doi: 10.1016/0960-0760(91)90012-T. PubMed DOI

Kaňková Š, et al. Disgust sensitivity is negatively associated with immune system activity in early pregnancy: Direct support for the compensatory prophylaxis hypothesis. Evol. Hum. Behav. 2022;43:234–241. doi: 10.1016/j.evolhumbehav.2022.02.001. DOI

Żelaźniewicz A, Pawłowski B. Disgust in pregnancy and fetus sex–longitudinal study. Physiol. Behav. 2015;139:177–181. doi: 10.1016/j.physbeh.2014.11.032. PubMed DOI

Polák J, Landová E, Frynta D. Undisguised disgust: A psychometric evaluation of a disgust propensity measure. Curr. Psychol. N. B. NJ. 2019;38:608–617. doi: 10.1007/s12144-018-9925-4. DOI

The jamovi project. jamovi. (2022).

Miyaura H, Iwata M. Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids. J. Immunol. Baltim. Md. 2002;1950(168):1087–1094. PubMed

Haidt J, McCauley C, Rozin P. Individual differences in sensitivity to disgust: A scale sampling seven domains of disgust elicitors. Personal. Individ. Differ. 1994;16:701–713. doi: 10.1016/0191-8869(94)90212-7. DOI

Tybur JM, Lieberman D, Griskevicius V. Microbes, mating, and morality: Individual differences in three functional domains of disgust. J. Pers. Soc. Psychol. 2009;97:103–122. doi: 10.1037/a0015474. PubMed DOI

Kupfer TR. Why are injuries disgusting? Comparing pathogen avoidance and empathy accounts. Emot. Wash. DC. 2018;18:959–970. PubMed

Fava GA, et al. Hypochondriacal fears and beliefs in pregnancy. Acta Psychiatr. Scand. 1990;82:70–72. doi: 10.1111/j.1600-0447.1990.tb01358.x. PubMed DOI

Odent M, et al. Fear of death during labour. Midwifery Today Int. Midwife. 2003;67:20–22. PubMed

Silva, M. M. de J., Nogueira, D. A., Clapis, M. J. & Leite, E. P. R. C. Anxiety in pregnancy: Prevalence and associated factors. Rev. Esc. Enferm. USP51, 1–8 (2017). PubMed

Soto-Balbuena C, et al. Incidence, prevalence and risk factors related to anxiety symptoms during pregnancy. Psicothema. 2018;30:257–263. PubMed

Polachek IS, Harari LH, Baum M, Strous RD. Postpartum anxiety in a cohort of women from the general population: Risk factors and association with depression during last week of pregnancy, postpartum depression and postpartum PTSD. Isr. J. Psychiatry Relat. Sci. 2014;51:128–134. PubMed

Miao H, et al. Congenital anomalies associated with ambient temperature variability during fetal organogenesis period of pregnancy: Evidence from 4.78 million births. Sci. Total Environ. 2021;798:149305. doi: 10.1016/j.scitotenv.2021.149305. PubMed DOI

Weinhold B. Environmental factors in birth defects: What we need to know. Environ. Health Perspect. 2009;117:A440–A447. doi: 10.1289/ehp.117-a440. DOI

Czeizel AE, Puhó E. Association between severe nausea and vomiting in pregnancy and lower rate of preterm births. Paediatr. Perinat. Epidemiol. 2004;18:253–259. doi: 10.1111/j.1365-3016.2004.00568.x. PubMed DOI

Hinkle SN, et al. Association of nausea and vomiting during pregnancy with pregnancy loss: A secondary analysis of a randomized clinical trial. JAMA Intern. Med. 2016;176:1621–1627. doi: 10.1001/jamainternmed.2016.5641. PubMed DOI PMC

Patil CL, Abrams ET, Steinmetz AR, Young SL. Appetite sensations and nausea and vomiting in pregnancy: An overview of the explanations. Ecol. Food Nutr. 2012;51:394–417. doi: 10.1080/03670244.2012.696010. PubMed DOI

Rantala MJ, et al. Evidence for the stress-linked immunocompetence handicap hypothesis in humans. Nat. Commun. 2012;3:694. doi: 10.1038/ncomms1696. PubMed DOI PMC

Fessler DMT, Navarrete CD. The effect of age on death disgust: Challenges to terror management perspectives. Evol. Psychol. 2005;3:147470490500300130. doi: 10.1177/147470490500300120. DOI

Olatunji BO, Haidt J, McKay D, David B. Core, animal reminder, and contamination disgust: Three kinds of disgust with distinct personality, behavioral, physiological, and clinical correlates. J. Res. Personal. 2008;42:1243–1259. doi: 10.1016/j.jrp.2008.03.009. DOI

van Overveld M, de Jong PJ, Peters ML, Schouten E. The Disgust Scale-R: A valid and reliable index to investigate separate disgust domains? Personal. Individ. Differ. 2011;51:325–330. doi: 10.1016/j.paid.2011.03.023. DOI

Oum RE, Lieberman D, Aylward A. A feel for disgust: Tactile cues to pathogen presence. Cogn. Emot. 2011;25:717–725. doi: 10.1080/02699931.2010.496997. PubMed DOI

Saluja S, Stevenson RJ. Perceptual and cognitive determinants of tactile disgust. Q. J. Exp. Psychol. 2019;72:2705–2716. doi: 10.1177/1747021819862500. PubMed DOI

Liuzza MT, et al. The Body odor disgust scale (BODS): Development and validation of a novel olfactory disgust assessment. Chem. Senses. 2016;5:107. doi: 10.1093/chemse/bjw107. PubMed DOI

Disgust as a primary emotional system and its clinical relevance

Association between Disgust Sensitivity during Pregnancy and Endogenous Steroids: A Longitudinal Study

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