Assessing regulated cell death modalities as an efficient tool for in vitro nanotoxicity screening: a review
Language English Country England, Great Britain Media print-electronic
Document type Review, Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Nanotoxicology, nanoparticles, reactive oxygen species, regulated cell death,
- MeSH
- Humans MeSH
- Neoplasms * MeSH
- Nanomedicine MeSH
- Nanostructures * toxicity MeSH
- Nanotechnology MeSH
- Necroptosis MeSH
- Reactive Oxygen Species metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Reactive Oxygen Species MeSH
Nanomedicine is a fast-growing field of nanotechnology. One of the major obstacles for a wider use of nanomaterials for medical application is the lack of standardized toxicity screening protocols for assessing the safety of newly synthesized nanomaterials. In this review, we focus on less frequently studied nanomaterials-induced regulated cell death (RCD) modalities, including eryptosis, necroptosis, pyroptosis, and ferroptosis, as a tool for in vitro nanomaterials safety evaluation. We summarize the latest insights into the mechanisms that mediate these RCDs in response to nanomaterials exposure. Comprehensive data from reviewed studies suggest that ROS (reactive oxygen species) overproduction and ROS-mediated pathways play a central role in nanomaterials-induced RCDs activation. On the other hand, studies also suggest that individual properties of nanomaterials, including size, shape, or surface charge, could determine specific toxicity pathways with consequent RCD induction as well. We anticipate that the evaluation of RCDs can become one of the mechanism-based screening methods in nanotoxicology. In addition to the toxicity assessment, evaluation of necroptosis-, pyroptosis-, and ferroptosis-promoting capacity of nanomaterials could simultaneously provide useful information for specific medical applications as could be their anti-tumor potential. Moreover, a detailed understanding of molecular mechanisms driving nanomaterials-mediated induction of immunogenic RCDs will substantially aid novel anti-tumor nanodrugs development.
BIOCEV 1st Faculty of Medicine Charles University Vestec Czechia
Department of Medical Biology Kharkiv National Medical University Kharkiv Ukraine
Institute for Scintillation Materials National Academy of Sciences of Ukraine Kharkiv Ukraine
References provided by Crossref.org
Erythronecroptosis: an overview of necroptosis or programmed necrosis in red blood cells
