Sensitivity of Papilledema as a Sign of Increased Intracranial Pressure
Status PubMed-not-MEDLINE Language English Country Switzerland Media electronic
Document type Journal Article
PubMed
37189972
PubMed Central
PMC10136908
DOI
10.3390/children10040723
PII: children10040723
Knihovny.cz E-resources
- Keywords
- increased intracranial pressure, optic disc swelling, papilledema,
- Publication type
- Journal Article MeSH
Our study evaluates the sensitivity of papilledema as a sign of high intracranial pressure in children. Patients younger than 18 years old, diagnosed with increased ICP, and who had received dilated fundus examination between 2019 and 2021 were retrospectively reviewed. Factors including the patient's age, sex, aetiology, duration of signs or symptoms, intracranial pressure (ICP), and presence of papilledema were evaluated. We included 39 patients in this study, whose mean age was 6.7 years. The 31 patients without papilledema had a mean age of 5.7 years, and 8 patients (20%) with papilledema had a mean age of 10.4 (p < 0.037). The mean duration of signs or symptoms was nine weeks in patients without papilledema and seven weeks in those with papilledema (p = 0.410). The leading causes of increased ICP with papilledema were supratentorial tumor (12.5%), infratentorial tumor (33.3%), and hydrocephalus (20%) (p = 0.479). Papilledema was statistically significantly more common in older patients. We found no statistical significance between sex, diagnosis, and symptoms. The relatively low incidence of papilledema (20%) in our study shows that papilledema's absence does not ensure the absence of increased ICP, especially in younger patients.
Department of Neurosurgery University Hospital Olomouc 779 00 Olomouc Czech Republic
Department of Ophthalmology University Hospital Olomouc 779 00 Olomouc Czech Republic
Department of Pediatrics University Hospital Olomouc 779 00 Olomouc Czech Republic
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Allen E.D., Byrd S.E., Darling C.F., Tomita T., Wilczynski M.A. The clinical and radiological evaluation of primary brain tumours in children, Part I: Clinical evaluation. J. Natl. Med. Assoc. 1993;85:445–451. PubMed PMC
Steffen H., Eifert B., Aschoff A., Kolling G.H., Völcker H.E. The diagnostic value of optic disc evaluation in acute elevated intracranial pressure. Ophthalmology. 1996;103:1229–1232. doi: 10.1016/S0161-6420(96)30518-6. PubMed DOI
Distelmaier F., Mayatepek E., Tibussek D. Probable idiopathic intracranial hypertension in pre-pubertal children. Arch. Dis. Child. 2008;93:356–357. doi: 10.1136/adc.2008.137158. PubMed DOI
Nazir S., O’Brien M., Qureshi N.H., Slape L., Green T.J., Phillips P.H. Sensitivity of papilledema as a sign of shunt failure in children. J. AAPOS. 2009;13:63–66. doi: 10.1016/j.jaapos.2008.08.003. PubMed DOI
Lee H.J., Phi J.H., Kim S.-K., Wang K.-C., Kim S.-J. Papilledema in Children with Hydrocephalus: Incidence and Associated Factors. J. Neurosurg. Pediatr. 2017;19:627–631. doi: 10.3171/2017.2.PEDS16561. PubMed DOI
Lin C.T., Riva-Cambrin J.K. Management of posterior fossa tumors and hydrocephalus in children: A review. Childs Nerv. Syst. 2015;31:1781–1789. doi: 10.1007/s00381-015-2781-8. PubMed DOI
Levatin P., Raskind R. Delayed appearance of papilledema. Can. J. Ophthalmol. 1973;8:451–455. PubMed
Ghose S. Optic nerve changes in hydrocephalus. Trans. Ophthalmol. Soc. U. K. 1983;103:217–220. PubMed
Hayreh S.S. Pathogenesis of optic disc edema in raised intracranial pressure. Prog. Retin. Eye Res. 2016;50:108–144. doi: 10.1016/j.preteyeres.2015.10.001. PubMed DOI PMC
Hayreh S.S. Pathogenesis of optic disc oedema in raised intracranial pressure. Trans. Ophthalmol. Soc. U. K. 1976;96:404407. PubMed
Chou S.Y., Digre K.B. Neuro-ophthalmic complications of raised intracranial pressure, hydrocephalus, and shunt malfunction. Neurosurg. Clin. N. Am. 1999;10:587–608. doi: 10.1016/S1042-3680(18)30160-8. PubMed DOI
Gaston H. Ophthalmic complications of spina bifida and hydrocephalus. Eye. 1991;5:279–290. doi: 10.1038/eye.1991.44. PubMed DOI
Aleksijevic D., Zapletalova J., Smolka V., Klaskova E., Wiedernnann J., Krahulik D., Vaverka J., Frysak Z. Neuro-endocrine dysfunction in children and adolescents after brain injury. Ceska A Slov. Neurol. A Neurochir. 2010;73:409–414.
Krahulik D., Nevrly M., Otruba P., Bardon J., Hrabálek L., Vaverka M., Kanovsky P. Placement accuracy of deep brain stimulation electrodes using the NexFrame© frameless system. Ceska A Slov. Neurol. A Neurochir. 2017;80:208–212. doi: 10.14735/amcsnn2017208. DOI
Katz D.M., Trobe J.D., Muraszko K.M., Dauser R.C. Shunt failure without ventriculomegaly proclaimed by ophthalmic findings. J. Neurosurg. 1994;81:721–725. doi: 10.3171/jns.1994.81.5.0721. PubMed DOI
Asai A., Hoffman H.J., Hendrick E.B., Humphreys R.P., Becker L.E. Primary intracranial neoplasms in the first year of life. Child’s Nerv. Syst. 1989;5:230–233. doi: 10.1007/BF00271024. PubMed DOI
Selhorst J.B., Gudeman S.K., Butterworth J.F., IV, Harbison J.W., Miller J.D., Becker D.P. Papilledema after acute head injury. Neurosurgery. 1985;16:357–363. doi: 10.1227/00006123-198503000-00013. PubMed DOI
Mizrachi I.B., Trobe J.D., Gebarski S.S., Garton H.J. Papilledema in the assessment of ventriculomegaly. J. Neuroophthalmol. 2006;26:260–263. doi: 10.1097/01.wno.0000249331.88098.b8. PubMed DOI
Newman N.J. Bilateral visual loss and disc edema in a 15-year-old girl. Surv. Ophthalmol. 1994;38:365–370. doi: 10.1016/0039-6257(94)90074-4. PubMed DOI
Scott C.J., Kardon R.H., Lee A.G., Frisén L., Wall M. Diagnosis and grading of papilledema in patients with raised intracranial pressure using optical coherence tomography vs clinical expert assessment using a clinical staging scale. Arch. Ophthalmol. 2010;128:705–711. doi: 10.1001/archophthalmol.2010.94. PubMed DOI
Corbett J.J. Neuro-ophthalmologic complications of hydrocephalus and shunting procedures. Semin. Neurol. 1986;6:111–123. doi: 10.1055/s-2008-1041454. PubMed DOI
Kulkarni A.V., Drake J.M., Armstrong D.C., Dirks P.B. Measurement of ventricular size: Reliability of the frontal and occipital horn ratio compared to subjective assessment. Pediatr. Neurosurg. 1999;31:65–70. doi: 10.1159/000028836. PubMed DOI
Watkins L., Hayward R., Andar U., Harkness W. The diagnosis of blocked cerebrospinal fluid shunts: A prospective study of referral to a paediatric neurosurgical unit. Child’s Nerv. Syst. 1994;10:87–90. doi: 10.1007/BF00302769. PubMed DOI