Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
37515769
DOI
10.1016/j.celrep.2023.112894
PII: S2211-1247(23)00905-1
Knihovny.cz E-resources
- Keywords
- 3D chromosome organization, Arabidopsis, CP: Molecular biology, CP: Plants, H3K27me3, Polycomb, TRB, Telomere Repeat Binding protein, chromatin accessibility, linker histone H1, telomere,
- MeSH
- Arabidopsis * genetics metabolism MeSH
- Chromatin MeSH
- Histones metabolism MeSH
- Polycomb Repressive Complex 2 metabolism MeSH
- Arabidopsis Proteins * genetics metabolism MeSH
- Telomere-Binding Proteins metabolism MeSH
- Mammals metabolism MeSH
- Telomere genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chromatin MeSH
- Histones MeSH
- Polycomb Repressive Complex 2 MeSH
- Arabidopsis Proteins * MeSH
- Telomere-Binding Proteins MeSH
While the pivotal role of linker histone H1 in shaping nucleosome organization is well established, its functional interplays with chromatin factors along the epigenome are just starting to emerge. Here we show that, in Arabidopsis, as in mammals, H1 occupies Polycomb Repressive Complex 2 (PRC2) target genes where it favors chromatin condensation and H3K27me3 deposition. We further show that, contrasting with its conserved function in PRC2 activation at genes, H1 selectively prevents H3K27me3 accumulation at telomeres and large pericentromeric interstitial telomeric repeat (ITR) domains by restricting DNA accessibility to Telomere Repeat Binding (TRB) proteins, a group of H1-related Myb factors mediating PRC2 cis recruitment. This study provides a mechanistic framework by which H1 avoids the formation of gigantic H3K27me3-rich domains at telomeric sequences and contributes to safeguard nucleus architecture.
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