Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved multi-subunit complexes that repress gene transcription by introducing trimethylation of lysine 27 on histone 3 (H3K27me3). PRC2 activity is of key importance for cell identity specification and developmental phase transitions in animals and plants. The composition, biochemistry, and developmental function of PRC2 in animal and flowering plant model species are relatively well described. Recent evidence demonstrates the presence of PRC2 complexes in various eukaryotic supergroups, suggesting conservation of the complex and its function. Here, we provide an overview of the current understanding of PRC2-mediated repression in different representatives of eukaryotic supergroups with a focus on the green lineage. By comparison of PRC2 in different eukaryotes, we highlight the possible common and diverged features suggesting evolutionary implications and outline emerging questions and directions for future research of polycomb repression and its evolution.

Biology Centre Institute of Plant Molecular Biology Czech Academy of Sciences 370 05 Ceske Budejovice Czech Republic

Faculty of Science University of South Bohemia 370 05 Ceske Budejovice Czech Republic

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PREDICTED: Histone-Binding Protein RBBP4 Isoform X2 [Anolis Carolinensis] [(accessed on 21 October 2021)]; Available online: Https://Www.Ncbi.Nlm.Nih.Gov/Protein/XP_003230003.3?Report=genbank&log$=prottop&blast_rank=1&RID=R2P2UE3N013.

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