Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
37515769
DOI
10.1016/j.celrep.2023.112894
PII: S2211-1247(23)00905-1
Knihovny.cz E-zdroje
- Klíčová slova
- 3D chromosome organization, Arabidopsis, CP: Molecular biology, CP: Plants, H3K27me3, Polycomb, TRB, Telomere Repeat Binding protein, chromatin accessibility, linker histone H1, telomere,
- MeSH
- Arabidopsis * genetika metabolismus MeSH
- chromatin MeSH
- histony metabolismus MeSH
- PRC2 metabolismus MeSH
- proteiny huseníčku * genetika metabolismus MeSH
- proteiny vázající telomery metabolismus MeSH
- savci metabolismus MeSH
- telomery genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- chromatin MeSH
- histony MeSH
- PRC2 MeSH
- proteiny huseníčku * MeSH
- proteiny vázající telomery MeSH
While the pivotal role of linker histone H1 in shaping nucleosome organization is well established, its functional interplays with chromatin factors along the epigenome are just starting to emerge. Here we show that, in Arabidopsis, as in mammals, H1 occupies Polycomb Repressive Complex 2 (PRC2) target genes where it favors chromatin condensation and H3K27me3 deposition. We further show that, contrasting with its conserved function in PRC2 activation at genes, H1 selectively prevents H3K27me3 accumulation at telomeres and large pericentromeric interstitial telomeric repeat (ITR) domains by restricting DNA accessibility to Telomere Repeat Binding (TRB) proteins, a group of H1-related Myb factors mediating PRC2 cis recruitment. This study provides a mechanistic framework by which H1 avoids the formation of gigantic H3K27me3-rich domains at telomeric sequences and contributes to safeguard nucleus architecture.
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