Aging in plants presents a paradox: while individual modules such as leaves and reproductive organs undergo senescence, the plant as a whole may display extraordinary longevity, enabled by its modular architecture and perpetually active meristems. This review explores aging and senescence in plants by challenging commonly held assumptions and integrating emerging insights from telomere biology and epigenetic regulation. We critically examine the role of telomere length as a determinant of replicative lifespan, arguing that its importance is often overstated, particularly in the context of plant systems where telomerase activity persists in meristematic tissues. In contrast, the epigenetic landscape-including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs-plays a dynamic and increasingly appreciated role in orchestrating senescence at cellular and organ levels. We synthesize current understanding of how these chromatin-level mechanisms interact with developmental cues and environmental stresses to regulate genome stability, transcriptional reprogramming, and longevity. By integrating chromosomal and epigenetic processes, this review provides a refined conceptual framework for understanding plant aging and highlights new opportunities to enhance resilience and lifespan in crops and long-lived species through targeted manipulation of telomere maintenance and epigenetic pathways.

Laboratory of Functional Genomics and Proteomics National Centre for Biomolecular Research Faculty of Science Masaryk University Brno 625 00 Czech Republic

Mendel Centre for Plant Genomics and Proteomics CEITEC Central European Institute of Technology Masaryk University Brno 625 00 Czech Republic

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