elektronický časopis
- Conspectus
- Obecná genetika. Obecná cytogenetika. Evoluce
- NML Fields
- genetika, lékařská genetika
- NML Publication type
- elektronické časopisy
sv. : ill.
- MeSH
- Epigenesis, Genetic * MeSH
- DNA Methylation MeSH
- Publication type
- Periodical MeSH
- Conspectus
- Biologické vědy
- NML Fields
- genetika, lékařská genetika
... Epigenetics: from phenomenon to field / Daniel E. ... ... Gottschling -- A brief history of epigenetics / Gary Felsenfeld -- Overview and concepts / C. ... ... David Allis, Thomas Jenuwein, and Danny Reinberg -- Epigenetics in Saccharomyces cerevisiae / Michael ... ... Selker -- Epigenetics of ciliates / Eric Meyer and Douglas L. ... ... Tamkun -- Histone variants and epigenetics / Steven Henikoff and M. Mitchell Smith -- ...
x, 502 s. : il.
- MeSH
- Epigenesis, Genetic MeSH
- Gene Expression Regulation MeSH
- Publication type
- Monograph MeSH
- Conspectus
- Biotechnologie. Genetické inženýrství
- NML Fields
- genetika, lékařská genetika
elektronický časopis
- Conspectus
- Obecná genetika. Obecná cytogenetika. Evoluce
- NML Fields
- genetika, lékařská genetika
- NML Publication type
- elektronické časopisy
Epigenetics, the study of non-DNA sequence-related heredity, is at the epicenter of modern medicine because it can help to explain the relationship between an individual's genetic background, the environment, aging, and disease. It can do so because the epigenetic state varies among tissues and during a lifetime, whereas the DNA sequence remains essentially the same. As cells adapt to a changing internal and external environment, epigenetic mechanisms can remember these changes in the normal programming and reprogramming of gene activity. The common disease genetic and epigenetic (CDGE) model provides an epidemiologic framework that can incorporate epigenetic with genetic variation in the context of age-related susceptibility to disease. Under CDGE, the epigenetic program can modify the effects of deleterious genes or may be influenced by an adverse environment. Thus, including epigenetics into epidemiologic studies of human disease may help explain the relationship between the genome and the environment and may provide new clues to modifying these effects in disease prevention and therapy.
Pediatric research, ISSN 0031-3998 vol. 61, no. 5/Part 2, May 2007
75 s. : il., tab. ; 28 cm
- MeSH
- Child MeSH
- Endocrine Disruptors MeSH
- Epigenesis, Genetic MeSH
- Genomic Imprinting MeSH
- DNA Methylation MeSH
- MicroRNAs MeSH
- DNA Mismatch Repair MeSH
- Developmental Biology MeSH
- Research MeSH
- Check Tag
- Child MeSH
- Publication type
- Collected Work MeSH
svazky
- MeSH
- Epigenesis, Genetic * MeSH
- Genetic Phenomena MeSH
- Genetics MeSH
- Publication type
- Periodical MeSH
- Conspectus
- Obecná genetika. Obecná cytogenetika. Evoluce
- NML Fields
- genetika, lékařská genetika
Nejlepší definice epigenetiky říká, že se zabývá studiem vlastností, jež jsou předávány prostřednictvím meiózy nebo mitózy a přitom nejsou závislé na primární struktuře DNA Britský genetik Adrian Bird k tomu dodává: „Epigenetika je užitečný termín, pokud nevíte, o co jde. Pokud to víte, nazvete to úplně jinak“ (Anonymus 2010).
The best working definition for the epigenetics is that it is the study of traits heritable through meiosis or mitosis that are not dependent on the primary DNA sequence. Even so, British geneticist Adrian Bird has commented: “Epigenetics is useful word if you don't know what's going on – if you do, you use something else” (Anonymus 2010).
- Keywords
- gen aguti,
- MeSH
- Heredity genetics MeSH
- Endocrine Disruptors MeSH
- Epigenomics * MeSH
- Histones physiology MeSH
- Hunger MeSH
- Humans MeSH
- DNA Methylation physiology MeSH
- RNA, Untranslated MeSH
- Check Tag
- Humans MeSH
- Publication type
- Popular Work MeSH
The ever-increasing interest in epigenetics comes from the fact that in the diverse life situations of organisms, e [...].
