Inequities in kidney health and kidney care
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
37580571
DOI
10.1038/s41581-023-00745-6
PII: 10.1038/s41581-023-00745-6
Knihovny.cz E-zdroje
- MeSH
- dostupnost zdravotnických služeb * MeSH
- ledviny MeSH
- lidé MeSH
- nemoci ledvin * MeSH
- výdaje na zdravotnictví MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Health inequity refers to the existence of unnecessary and unfair differences in the ability of an individual or community to achieve optimal health and access appropriate care. Kidney diseases, including acute kidney injury and chronic kidney disease, are the epitome of health inequity. Kidney disease risk and outcomes are strongly associated with inequities that occur across the entire clinical course of disease. Insufficient investment across the spectrum of kidney health and kidney care is a fundamental source of inequity. In addition, social and structural inequities, including inequities in access to primary health care, education and preventative strategies, are major risk factors for, and contribute to, poorer outcomes for individuals living with kidney diseases. Access to affordable kidney care is also highly inequitable, resulting in financial hardship and catastrophic health expenditure for the most vulnerable. Solutions to these injustices require leadership and political will. The nephrology community has an important role in advocacy and in identifying and implementing solutions to dismantle inequities that affect kidney health.
Aberdeen Centre for Health Data Science University of Aberdeen Aberdeen UK
Association Renaloo Paris France
Department of Medicine Kwame Nkrumah University of Science and Technology Kumasi Ghana
Department of Paediatric Nephrology St John's Medical College Bengaluru India
Department of Paediatrics and Child Health University of Cape Town Cape Town South Africa
Departments of Epidemiology and Surgery Johns Hopkins University Baltimore MD USA
European Kidney Health Alliance Brussels Belgium
Faculty of Medicine and Health Sciences Ghent University Ghent Belgium
Imperial College Healthcare NHS Trust Imperial College Renal and Transplant Center London UK
Renal Division Brigham and Women's Hospital Harvard Medical School Boston MA USA
Renal Unit Directorate of Medicine Komfo Anokye Teaching Hospital Kumasi Ghana
Rural and Remote Health Flinders University Adelaide South Australia Australia
Zobrazit více v PubMed
Kawachi, I., Subramanian, S. V. & Almeida-Filho, N. A glossary for health inequalities. J. Epidemiol. Community Health 56, 647–652 (2022). DOI
World Health Organisation. Health Topics — Health Equity. https://www.who.int/health-topics/health-equity (2010).
Nicholas, S. B., Kalantar-Zadeh, K. & Norris, K. C. Socioeconomic disparities in chronic kidney disease. Adv. Chronic Kidney Dis. 22, 6–15 (2015). PubMed DOI PMC
Martin, D. E. et al. Ethical challenges in nephrology: a call for action. Nat. Rev. Nephrol. 16, 603–613 (2020). PubMed DOI
The Health Foundation. A Communications Toolkit for People Working in Public Health. https://www.health.org.uk/publications/how-to-talk-about-the-building-blocks-of-health (2022).
Lynch, J. W., Kaplan, G. A. & Salonen, J. T. Why do poor people behave poorly? Variation in adult health behaviours and psychosocial characteristics by stages of the socioeconomic lifecourse. Soc. Sci. Med. 44, 809–819 (1997). PubMed DOI
Luyckx, V. A., Cherney, D. Z. I. & Bello, A. K. Preventing CKD in developed countries. Kidney Int. Rep. 5, 263–277 (2020). PubMed DOI
Sawhney, S. et al. Care processes and outcomes of deprivation across the clinical course of kidney disease: findings from a high-income country with universal healthcare. Nephrol. Dial. Transpl. 38, 1170–1182 (2023). DOI
Vanholder, R. et al. Reducing the costs of chronic kidney disease while delivering quality health care: a call to action. Nat. Rev. Nephrol. 13, 393–409 (2017). PubMed DOI
The International Society of Nephrology. Global Kidney Health Atlas. https://www.theisn.org/initiatives/global-kidney-health-atlas/ (2023).
Collaboration GBDCKD. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet 395 709-733 (2020).
Minutolo, R. et al. Detection and awareness of moderate to advanced CKD by primary care practitioners: a cross-sectional study from Italy. Am. J. Kidney Dis. 52, 444–453 (2008). PubMed DOI
Levin, A. et al. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet 390, 1888–1917 (2017). PubMed DOI
Matsushita, K. et al. Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data. Lancet Diabetes Endocrinol. 3, 514–525 (2015). PubMed DOI PMC
Thomas, B. et al. Global cardiovascular and renal outcomes of reduced GFR. J. Am. Soc. Nephrol. 28, 2167–2179 (2017). PubMed DOI PMC
Luyckx, V. A. Equity is key to build back better after COVID-19: prioritize noncommunicable diseases and kidney health. Kidney360 2, 747–750 (2021). PubMed DOI PMC
Vanholder, R. et al. Fighting the unbearable lightness of neglecting kidney health: the decade of the kidney. Clin. Kidney J. 14, 1719–1730 (2021). PubMed DOI PMC
European Commission. Research and Innovation. https://ec.europa.eu/info/research-and-innovation/research-area/health-research-and-innovation_en (accessed 31 July 2023).
World Health Organisation Europe. Health topics. https://www.who.int/europe/health-topics (accessed 31 July 2023).
EuroHealthNet. EuroHealthNet provides input for the EU NCD initiative. “Healthier Together”. https://eurohealthnet.eu/publication/eurohealthnet-provides-input-for-the-eu-ncd-initiative-healthier-together/?gclid=CjwKCAjwpKyYBhB7EiwAU2Hn2X2DCd8zG1iKjcvo8EsmpZmOhfnEcqmgzQd9egkTXxml5HMr451FdBoCbmAQAvD_BwE (2022).
NHS. Understanding what the public know about about their kidneys and what they do. thinkkidneys.nhs.uk, http://www.thinkkidneys.nhs.uk/aki/wp-content/uploads/sites/2/2015/01/Understanding-what-the-public-know-about-their-kidneys-and-what-they-do.pdf (2022).
Tonelli, M. et al. Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study. Lancet 380, 807–814 (2012). PubMed DOI
IHME. https://vizhub.healthdata.org/gbd-results .
Institute for Health Metrics and Evaluation. Global Burden of Disease Results. https://vizhub.healthdata.org/gbd-results/ (2019).
Liyanage, T. et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet 385, 1975–1982 (2015). PubMed DOI
Lewington, A. J., Cerda, J. & Mehta, R. L. Raising awareness of acute kidney injury: a global perspective of a silent killer. Kidney Int. 84, 457–467 (2013). PubMed DOI PMC
Luyckx, V. Getting chronic kidney disease on the map. NSAP 22, 115–120 (2022).
Mehta, R. L. et al. International Society of Nephrology’s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet 385, 2616–2643 (2015). PubMed DOI
Mora, C. et al. Over half of known human pathogenic diseases can be aggravated by climate change. Nat. Clim. Chang. 12, 869–875 (2022). PubMed DOI PMC
Mills, K. T. et al. A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010. Kidney Int. 88, 950–957 (2015). PubMed DOI PMC
Lameire, N. The definitions and staging systems of acute kidney injury and their limitations in practice. Arab. J. Nephrol. Transpl. 6, 145–152 (2013).
Susantitaphong, P. et al. World incidence of AKI: a meta-analysis. Clin. J. Am. Soc. Nephrol. 8, 1482–1493 (2013). PubMed DOI PMC
Institute for Health Metrics and Evaluation. Global Burden of Disease - Compare. https://vizhub.healthdata.org/gbd-compare (2020).
Vart, P., Reijneveld, S. A., Bultmann, U. & Gansevoort, R. T. Added value of screening for CKD among the elderly or persons with low socioeconomic status. Clin. J. Am. Soc. Nephrol. 10, 562–570 (2015). PubMed DOI PMC
van Rijn, M. H. C., Alencar de Pinho, N., Wetzels, J. F., van den Brand, J. & Stengel, B. Worldwide disparity in the relation between CKD prevalence and kidney failure risk. Kidney Int. Rep. 5, 2284–2291 (2020). PubMed DOI PMC
Xie, Y. et al. Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016. Kidney Int. 94, 567–581 (2018). PubMed DOI
Sever, M. et al. A roadmap for optimizing chronic kidney disease patient care and patient-oriented research in the Eastern European nephrology community. Clin. Kidney J. 14, 23–35 (2020). PubMed DOI PMC
de Jong, R. W. et al. Results of the European EDITH nephrologist survey on factors influencing treatment modality choice for end-stage kidney disease. Nephrol. Dial. Transpl. 37, 126–38 (2021). DOI
Lunney, M. et al. Availability, accessibility, and quality of conservative kidney management worldwide. Clin. J. Am. Soc. Nephrol. 16, 79–87 (2020). PubMed DOI PMC
Kevin Tucker, J. Social justice as a tool to eliminate inequities in kidney disease. Semin. Nephrol. 41, 203–10 (2021). PubMed DOI
Etheredge, H. & Fabian, J. Challenges in expanding access to dialysis in South Africa-expensive modalities, cost constraints and human rights. Healthcare 5, 38 (2017). PubMed DOI PMC
The World Bank. Gini index. data.worldbank.org, https://data.worldbank.org/indicator/SI.POV.GINI (2023).
Institute for Health Metrics and Evaluation. Epi Visualization, https://vizhub.healthdata.org/epi/ (2019).
Ashuntantang, G. et al. Outcomes in adults and children with end-stage kidney disease requiring dialysis in sub-Saharan Africa: a systematic review. Lancet Glob. Health 5, e408–e417 (2017). PubMed DOI
Caskey, F. J. et al. Global variation in renal replacement therapy for end-stage renal disease. Nephrol. Dial. Transpl. 26, 2604–2610 (2011). DOI
Stel, V. S. et al. Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe. Kidney Int. 100, 182–195 (2021). PubMed DOI
Norton, J. M. et al. Social determinants of racial disparities in CKD. J. Am. Soc. Nephrol. 27, 2576–2595 (2016). PubMed DOI PMC
Htay, H. et al. Global access of patients with kidney disease to health technologies and medications: findings from the Global Kidney Health Atlas project. Kidney Int. Suppl. 8, 64–73 (2018). DOI
Francis, A. et al. Barriers to accessing essential medicines for kidney disease in low- and lower middle-income countries. Kidney Int. 102, 969–973 (2022). PubMed DOI
Sharif, M. U., Elsayed, M. E. & Stack, A. G. The global nephrology workforce: emerging threats and potential solutions! Clin. Kidney J. 9, 11–22 (2016). PubMed DOI
Kalantar-Zadeh, K. et al. Living well with kidney disease by patient and care-partner empowerment: kidney health for everyone everywhere. Kidney Int. 99, 278–284 (2021). PubMed DOI
Carter, S. A. et al. Identifying outcomes important to patients with glomerular disease and their caregivers. Clin. J. Am. Soc. Nephrol. 15, 673–684 (2020). PubMed DOI PMC
Morton, R. L. et al. Impact of CKD on household income. Kidney Int. Rep. 3, 610–618 (2018). PubMed DOI
Garcia-Garcia, G. et al. Chronic kidney disease (CKD) in disadvantaged populations. Clin. Kidney J. 8, 3–6 (2015). PubMed DOI
Banerjee, T. et al. Food insecurity, CKD, and subsequent ESRD in US adults. Am. J. Kidney Dis. 70, 38–47 (2017). PubMed DOI PMC
Wilkinson, E., Brettle, A., Waqar, M. & Randhawa, G. Inequalities and outcomes: end stage kidney disease in ethnic minorities. BMC Nephrol. 20, 234 (2097). DOI
Mohottige, D., Diamantidis, C. J., Norris, K. C. & Boulware, L. E. Racism and kidney health: turning equity into a reality. Am. J. Kidney Dis. 77, 951–962 (2021). PubMed DOI
Mohottige, D. & Lunn, M. R. Advancing equity in nephrology: enhancing care for LGBTQ+ patients and our workforce. Clin. J. Am. Soc. Nephrol. 14, 1094–1096 (2019). PubMed DOI PMC
Norris, K. C. & Beech, B. M. Social determinants of kidney health: focus on poverty. Clin. J. Am. Soc. Nephrol. 16, 809–811 (2021). PubMed DOI PMC
Hall, Y. N. Social determinants of health: addressing unmet needs in nephrology. Am. J. Kidney Dis. 72, 582–591 (2018). PubMed DOI
Crews, D. C. & Novick, T. K. Social determinants of CKD hotspots. Semin. Nephrol. 39, 256–262 (2019). PubMed DOI PMC
Brandt, E. J., Chang, T., Leung, C., Ayanian, J. Z. & Nallamothu, B. K. Food insecurity among individuals with cardiovascular disease and cardiometabolic risk factors across race and ethnicity in 1999-2018. JAMA Cardiol. 7, 1218–1226 (2012). DOI
Crews, D. C., Bello, A. K. & Saadi, G. 2019 World Kidney Day editorial — burden, access, and disparities in kidney disease. J. Bras. Nefrol. 41, 1–9 (2019). PubMed DOI PMC
Tannor, E. K., Awaku, Y. A., Boima, V. & Antwi, S. The geographical distribution of dialysis services in Ghana. Ren. Repl. Ther. 4, 3 (2018). DOI
Furia, F. F. et al. Developing nephrology services in low income countries: a case of Tanzania. BMC Nephrol. 20, 378 (2019). PubMed DOI PMC
Naicker, S., Eastwood, J. B., Plange-Rhule, J. & Tutt, R. C. Shortage of healthcare workers in sub-Saharan Africa: a nephrological perspective. Clin. Nephrol. 74, S129–S133 (2010). PubMed
van Zwieten, A., Wong, G. & Qader, M. A. Tackling health inequities for children and adolescents with CKD-A call to advocacy and action across the life course. Kidney Int. Rep. 7, 671–674 (2022). PubMed DOI PMC
Swartling, O. et al. Sex differences in the recognition, monitoring, and management of CKD in health care: an observational cohort study. J. Am. Soc. Nephrol. 33, 1903–1914 (2022). PubMed DOI PMC
Ravani, P. et al. Association of age with risk of kidney failure in adults with stage IV chronic kidney disease in Canada. JAMA Netw. Open. 3, e2017150 (2020). PubMed DOI PMC
O’Hare, A. M. How useful is an age-neutral model of chronic kidney disease? JAMA Netw. Open. 3, e2017592 (2020). PubMed DOI
Scholes-Robertson, N. et al. Australian rural caregivers’ experiences in supporting patients with kidney failure to access dialysis and kidney transplantation: a qualitative study. Am. J. Kidney Dis. 80, 773–782.e1 (2022). PubMed DOI
Arici, M. Refugees with kidney disease: an increasing global challenge. Nat. Rev. Nephrol. 7, 366–367 (2021). DOI
Van Biesen, W., Vanholder, R., Ernandez, T., Drewniak, D. & Luyckx, V. Caring for migrants and refugees with end-stage kidney disease in Europe. Am. J. Kidney Dis. 71, 701–709 (2018). PubMed DOI
Cervantes, L., Hasnain-Wynia, R., Steiner, J. F., Chonchol, M. & Fischer, S. Patient navigation: addressing social challenges in dialysis patients. Am. J. Kidney Dis. 76, 121–129 (2020). PubMed DOI
Sachs, J., Lafortune, G., Kroll, C., Fuller, G., Woelm, F. Sustainable Development Report 2022. From Crisis to Sustainable Development: the SDGs as Roadmap to 2030 and Beyond (Cambridge Univ. Press, 2022).
Morton, R. L. et al. Impact of educational attainment on health outcomes in moderate to severe CKD. Am. J. Kidney Dis. 67, 31–39 (2016). PubMed DOI PMC
Arogundade, F. A. et al. Burden of end-stage renal disease in sub-Saharan Africa. Clin. Nephrol. 93, 3–7 (2020). PubMed DOI
Kretchy, I. A. et al. Prevalence, patterns and beliefs about the use of herbal medicinal products in Ghana: a multi-centre community-based cross-sectional study. Trop. Med. Int. Health 26, 410–420 (2021). PubMed DOI
Luyckx, V. A., Miljeteig, I., Ejigu, A. M. & Moosa, M. R. Ethical challenges in the provision of dialysis in resource-constrained environments. Semin. Nephrol. 37, 273–286 (2017). PubMed DOI
Sever, M. S. et al. Armed conflicts and kidney patients: a consensus statement from the renal disaster relief task force of the ERA. Nephrol. Dial. Transpl. 38, 56–65 (2023). DOI
Eneanya, N. D. et al. Health inequities and the inappropriate use of race in nephrology. Nat. Rev. Nephrol. 18, 84–94 (2022). PubMed DOI
Hounkpatin, H. O. et al. Ethnic minority disparities in progression and mortality of pre-dialysis chronic kidney disease: a systematic scoping review. BMC Nephrol. 21, 217 (2020). PubMed DOI PMC
Epstein, A. M. et al. Racial disparities in access to renal transplantation — clinically appropriate or due to underuse or overuse? N. Engl. J. Med. 343, 1537–1544 (2000). PubMed DOI PMC
Purnell, T. S. et al. Association of race and ethnicity with live donor kidney transplantation in the United States from 1995 to 2014. JAMA 319, 49–61 (2018). PubMed DOI PMC
Mehrotra, R. et al. Racial and ethnic disparities in use of and outcomes with home dialysis in the United States. J. Am. Soc. Nephrol. 27, 2123–2134 (2016). PubMed DOI
Luyckx, V. A. & Brenner, B. M. Birth weight, malnutrition and kidney-associated outcomes-a global concern. Nat. Rev. Nephrol. 11, 135–149 (2015). PubMed DOI
LaVeist, T. A. et al. The economic burden of racial, ethnic, and educational health inequities in the US. JAMA 329, 1682–1692 (2023). PubMed DOI
Purnell, T. S., Hall, Y. N. & Boulware, L. E. Understanding and overcoming barriers to living kidney donation among racial and ethnic minorities in the United States. Adv. Chronic Kidney Dis. 19, 244–251 (2012). PubMed DOI PMC
Obermeyer, Z., Powers, B., Vogeli, C. & Mullainathan, S. Dissecting racial bias in an algorithm used to manage the health of populations. Science 366, 447–453 (2019). PubMed DOI
Gichoya, J. W. et al. AI recognition of patient race in medical imaging: a modelling study. Lancet Digit. Health 4, e406–e414 (2022). PubMed DOI PMC
Williams, W. W., Hogan, J. W. & Ingelfinger, J. R. Time to eliminate health care disparities in the estimation of kidney function. N. Engl. J. Med. 385, 1804–1806 (2021). PubMed DOI
Delanaye, P. et al. The « race » correction in estimating glomerular filtration rate: an European point of view. Curr. Opin. Nephrol. Hypertens. 30, 525–530 (2021). PubMed DOI
Delgado, C. et al. A unifying approach for GFR estimation: recommendations of the NKF-ASN task force on reassessing the inclusion of race in diagnosing kidney disease. Am. J. Kidney Dis. 79, 268–88 e1 (2022). PubMed DOI
Weiss B. D. Health Literacy and Patient Safety: Help Patients Understand: Manual for Clinicians, 2nd edn (American Medical Association Foundation and American Medical Association, 2022).
Vellar, L., Mastroianni, F. & Lambert, K. Embedding health literacy into health systems: a case study of a regional health service. Aust. Health Rev. 41, 621–625 (2017). PubMed DOI
Levy, H. & Janke, A. Health literacy and access to care. J. Health Commun. 21, Suppl. 1 43–50 (2016). PubMed DOI PMC
Blumenthal, S. J. & Kagen, J. MSJAMA. The effects of socioeconomic status on health in rural and urban America. JAMA 287, 109 (2002). PubMed DOI
Scholes-Robertson, N. et al. Perspectives of a proposed patient navigator programme for people with chronic kidney disease in rural communities: report from national workshops. Nephrology 27, 886–896 (2022). PubMed DOI
Moist, L. M. et al. Travel time to dialysis as a predictor of health-related quality of life, adherence, and mortality: the dialysis outcomes and practice patterns study (DOPPS). Am. J. Kidney Dis. 51, 641–650 (2008). PubMed DOI
Evans, R., Rudd, P., Hemmila, U., Dobbie, H. & Dreyer, G. Deficiencies in education and experience in the management of acute kidney injury among Malawian healthcare workers. Malawi Med. J. 27, 101–103 (2015). PubMed DOI PMC
Baelani, I. et al. Identifying resource needs for sepsis care and guideline implementation in the Democratic Republic of the Congo: a cluster survey of 66 hospitals in four eastern provinces. Middle East. J. Anaesthesiol. 21, 559–575 (2012). PubMed
Olowu, W. A. et al. Outcomes of acute kidney injury in children and adults in sub-Saharan Africa: a systematic review. Lancet Glob. Health 4, e242–e250 (2016). PubMed DOI
Ramachandran, R. et al. Challenges in diagnosis and management of glomerular disease in resource-limited settings. Kidney Int. Rep. 7, 2141–2149 (2022). PubMed DOI PMC
Yeung, E. et al. Current status of health systems financing and oversight for end-stage kidney disease care: a cross-sectional global survey. BMJ Open 11, e047245 (2021). PubMed DOI PMC
Ludlow, M. J., Lauder, L. A., Mathew, T. H., Hawley, C. M. & Fortnum, D. Australian consumer perspectives on dialysis: first national census. Nephrology 17, 703–709 (2012). PubMed DOI
Niang, A., Iyengar, A. & Luyckx, V. A. Hemodialysis versus peritoneal dialysis in resource-limited settings. Curr. Opin. Nephrol. Hypertens. 27, 463–471 (2018). PubMed DOI
van der Tol, A., Lameire, N., Morton, R. L., Van Biesen, W. & Vanholder, R. An international analysis of dialysis services reimbursement. Clin. J. Am. Soc. Nephrol. 14, 84–93 (2019). PubMed DOI
Okpechi, I. G. et al. The case for increased peritoneal dialysis utilization in low- and lower-middle-income countries. Nephrology 27, 391–403 (2022). PubMed DOI
Brown, E. A. et al. Availability of assisted peritoneal dialysis in Europe: call for increased and equal access. Nephrol. Dial. Transpl. 37, 2080–2089 (2022). DOI
Hamroun, A. et al. Barriers to conservative care from patients’ and nephrologists’ perspectives: the CKD-REIN Study. Nephrol. Dial. Transpl. 37, 2438–2448 (2022). DOI
Wolfe, R. A. et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N. Engl. J. Med. 341, 1725–1730 (1999). PubMed DOI
Giwa, S. et al. The promise of organ and tissue preservation to transform medicine. Nat. Biotechnol. 35, 530–542 (2017). PubMed DOI PMC
Bello, A. K. et al. Global kidney health atlas (GKHA): design and methods. Kidney Int. Suppl. 7, 145–153 (2012). DOI
Wu, D. A. et al. Global trends and challenges in deceased donor kidney allocation. Kidney Int. 91, 1287–1299 (2017). PubMed DOI
Vanholder, R. et al. Organ donation and transplantation: a multi-stakeholder call to action. Nat. Rev. Nephrol. 17, 554–568 (2021). PubMed DOI PMC
Tiong, M. K., Thomas, S., Fernandes, D. K. & Cherian, S. Examining barriers to timely waitlisting for kidney transplantation for Indigenous Australians in central Australia. Intern. Med. J. 52, 288–294 (2022). PubMed DOI
Rota-Musoll, L. et al. An intersectional gender analysis in kidney transplantation: women who donate a kidney. BMC Nephrol. 22, 59 (2021). PubMed DOI PMC
Hecking, M. et al. Sex-specific differences in mortality and incident dialysis in the chronic kidney disease outcomes and practice patterns study. Kidney Int. Rep. 7, 410–423 (2022). PubMed DOI
Sever, M. S. et al. Ethical and medical dilemmas in paid living kidney donor transplantation. Transpl. Rev. 36, 100726 (2022). DOI
Steering Committee of the Istanbul S. Organ trafficking and transplant tourism and commercialism: the declaration of Istanbul. Lancet 372, 5–6 (2008). DOI
Banerjee, S., Kamath, N., Antwi, S. & Bonilla-Felix, M. Paediatric nephrology in under-resourced areas. Pediatr. Nephrol. 37, 959–972 (2022). PubMed DOI
Macedo, E. et al. Recognition and management of acute kidney injury in children: the ISN 0by25 Global Snapshot study. PLoS ONE 13, e0196586 (2018). PubMed DOI PMC
Kennedy, S. E., Bailey, R. & Kainer, G. Causes and outcome of late referral of children who develop end-stage kidney disease. J. Paediatr. Child. Health 48, 253–258 (2012). PubMed DOI
Chesnaye, N. C. et al. Mortality risk in European children with end-stage renal disease on dialysis. Kidney Int. 89, 1355–1362 (2016). PubMed DOI
Pais, P., Blydt-Hansen, T. D., Michael Raj, J. A., Dello Strologo, L. & Iyengar, A. Low renal transplantation rates in children with end-stage kidney disease: a study of barriers in a low-resource setting. Pediatr. Transpl. 25, e13867 (2021). DOI
Sarnak, D. O., Squires, D., Kuzmak, G. & Bishop, S. Paying for prescription drugs around the world: why is the U.S. an outlier? Issue Brief. 2017, 1–14 (2017). PubMed
Vanholder, R., Van Biesen, W. & Lameire, N. Renal replacement therapy: how can we contain the costs? Lancet 383, 1783–1785 (2014). PubMed DOI
Mohnen, S. M. et al. Healthcare costs of patients on different renal replacement modalities — analysis of Dutch health insurance claims data. PLoS ONE 14, e0220800 (2019). PubMed DOI PMC
de Vries, E. F., Los, J., de Wit, G. A. & Hakkaart-van, R. L. Patient, family and productivity costs of end-stage renal disease in the Netherlands; exposing non-healthcare related costs. BMC Nephrol. 22, 341 (2021). PubMed DOI PMC
Essue, B. M. et al. in Disease Control Priorities Improving Health and Reducing Poverty 3 edn (eds Jamison, D. T., Gelband H., Horton S. et al.) 121–143 (World Bank, 2018).
Luyckx, V. A. & Moosa, M. R. Priority setting as an ethical imperative in managing global dialysis access and improving kidney care. Semin. Nephrol. 41, 230–241 (2021). PubMed DOI
Sculpher M., Revill P., Ochalek J. M., Claxton K. in What’s In, What’s Out? Designing Benefits for Universal Health Coverage (eds Glassman, A. et al.) 115–140 (Center for Global Development, USA).
Howell, M., Walker, R. C. & Howard, K. Cost effectiveness of dialysis modalities: a systematic review of economic evaluations. Appl. Health Econ. Health Policy 17, 315–330 (2019). PubMed DOI
Johri, M. & Norheim, O. F. Can cost-effectiveness analysis integrate concerns for equity? Systematic review. Int. J. Technol. Assess. Health Care 28, 125–132 (2012). PubMed DOI
Himmelfarb, J., Vanholder, R., Mehrotra, R. & Tonelli, M. The current and future landscape of dialysis. Nat. Rev. Nephrol. 16, 573–585 (2020). PubMed DOI PMC
van der Tol, A. et al. A call for harmonization of European kidney care: dialysis reimbursement and distribution of kidney replacement therapies. Nephrol. Dial. Transpl. 35, 979–986 (2020). DOI
Van Biesen, W. et al. Considerations on equity in management of end-stage kidney disease in low- and middle-income countries. Kidney Int. Suppl. 10, e63–e71 (2020). DOI
Ashu, J. T. et al. Challenges to the right to health in sub-Saharan Africa: reflections on inequities in access to dialysis for patients with end-stage kidney failure. Int. J. Equity Health 21, 126 (2022). PubMed DOI PMC
Crosby, L. et al. Dialysis in Africa: the need for evidence-informed decision making. Lancet Glob. Health 8, e476–e477 (2020). PubMed DOI PMC
Luyckx, V. A. et al. Sustainable Development Goals relevant to kidney health: an update on progress. Nat. Rev. Nephrol. 17, 15–32 (2021). PubMed DOI
Sumaili, E. K. et al. High prevalence of undiagnosed chronic kidney disease among at-risk population in Kinshasa, the Democratic Republic of Congo. BMC Nephrol. 10, 18 (2009). PubMed DOI PMC
World Health Organization. Saving Lives, Spending Less: The Case for Investing In Noncommunicable Diseases. https://www.who.int/publications/i/item/9789240041059 (2021).
Ameh, O. I., Ekrikpo, U. E. & Kengne, A. P. Preventing CKD in low- and middle-income countries: a call for urgent action. Kidney Int. Rep. 5, 255–262 (2020). PubMed DOI
Karpman, D. & Hoglund, P. Orphan drug policies and use in pediatric nephrology. Pediatr. Nephrol. 32, 1–6 (2017). PubMed DOI
Zimmermann, B. M., Eichinger, J. & Baumgartner, M. R. A systematic review of moral reasons on orphan drug reimbursement. Orphanet J. Rare Dis. 16, 292 (2021). PubMed DOI PMC
Berdud, M., Drummond, M. & Towse, A. Establishing a reasonable price for an orphan drug. Cost. Eff. Resour. Alloc. 18, 31 (2020). PubMed DOI PMC
Onakpoya, I. J., Spencer, E. A., Thompson, M. J. & Heneghan, C. J. Effectiveness, safety and costs of orphan drugs: an evidence-based review. BMJ Open. 5, e007199 (2015). PubMed DOI PMC
Kesselheim, A. S. et al. The prevalence and cost of unapproved uses of top-selling orphan drugs. PLoS ONE 7, e31894 (2012). PubMed DOI PMC
Young, K. E., Soussi, I. & Toumi, M. The perverse impact of external reference pricing (ERP): a comparison of orphan drugs affordability in 12 European countries. A call for policy change. J. Mark. Access. Health Policy 5, 1369817 (2017). PubMed DOI PMC
Gammie, T., Lu, C. Y. & Babar, Z. U. Access to orphan drugs: a comprehensive review of legislations, regulations and policies in 35 countries. PLoS ONE 10, e0140002 (2015). PubMed DOI PMC
Marmot, M. Just societies, health equity, and dignified lives: the PAHO equity commission. Lancet 392, 2247–2250 (2018). PubMed DOI
Garcia, G. G. et al. Sex and gender differences in chronic kidney disease and access to care around the globe. Semin. Nephrol. 42, 101–113 (2022). PubMed DOI
Moosa, M. R. & Luyckx, V. A. The realities of rationing in health care. Nat. Rev. Nephrol. 17, 435–436 (2021). PubMed DOI PMC
Venkatapuram, S. Health Justice: An Argument from the Capabilities Approach (Polity Press, 2011).
Uberoi, D. & Forman, L. What role can the right to health play in advancing equity in kidney care? Semin. Nephrol. 41, 220–229 (2021). PubMed DOI
Braveman, P. A. et al. Health disparities and health equity: the issue is justice. Am. J. Public. Health 101, Suppl. 1 S149–S155 (2011). PubMed DOI PMC
World Health Organization. Noncommunicable diseases. https://www.who.int/teams/surveillance-of-noncommunicable-diseases/about/ncds (accessed 31 July 2023).
Chin, M. H. et al. A roadmap and best practices for organizations to reduce racial and ethnic disparities in health care. J. Gen. Intern. Med. 27, 992–1000 (2012). PubMed DOI PMC
European Commission. Public Health. European Reference Networks. https://health.ec.europa.eu/european-reference-networks/overview_en (2023).
Plahte, J. Tiered pricing of vaccines: a win-win-win situation, not a subsidy. Lancet Infect. Dis. 5, 58–63 (2005). PubMed DOI
Gopichandran, V. et al. Developing the ethics of implementation research in health. Implement. Sci. 11, 161 (2016). PubMed DOI PMC
Jager, K. J. et al. A snapshot of European registries on chronic kidney disease patients not on kidney replacement therapy. Nephrol. Dial. Transpl. 37, 8–13 (2021). DOI
Qaseem, A., Hopkins, R. H. Jr., Sweet, D. E., Starkey, M. & Shekelle, P. Screening, monitoring, and treatment of stage 1 to 3 chronic kidney disease: a clinical practice guideline from the American College of Physicians. Ann. Intern. Med. 159, 835–847 (2013). PubMed DOI
Greer, R. & Boulware, L. E. Reducing CKD risks among vulnerable populations in primary care. Adv. Chronic Kidney Dis. 22, 74–80 (2015). PubMed DOI PMC
Hull, S., Dreyer, G., Badrick, E., Chesser, A. & Yaqoob, M. M. The relationship of ethnicity to the prevalence and management of hypertension and associated chronic kidney disease. BMC Nephrol. 12, 41 (2011). PubMed DOI PMC
Tenkorang, E. Y. & Kuuire, V. Z. Noncommunicable diseases in Ghana: does the theory of social gradient in health hold? Health Educ. Behav. 43, 25S–36S (2016). PubMed DOI
Wardle, J. & Steptoe, A. Socioeconomic differences in attitudes and beliefs about healthy lifestyles. J. Epidemiol. Community Health 57, 440–443 (2003). PubMed DOI PMC
United Nations. Department of Economic and Social Affairs. Sustainable Development Goal 3, https://sdgs.un.org/goals/goal3 (2022).
Chapman, A. R. Assessing the universal health coverage target in the sustainable development goals from a human rights perspective. BMC Int. Health Hum. Rights 16, 33 (2016). PubMed DOI PMC
Annemans, L. A proposal for value informed, affordable (“via”) prices for innovative medicines. J. Med. Econ. 22, 1235–1239 (2019). PubMed DOI
Cookson, R. et al. Using cost-effectiveness analysis to address health equity concerns. Value Health 20, 206–212 (2017). PubMed DOI PMC
Bukhman, G. et al. From a Lancet commission to the NCDI poverty network: reaching the poorest billion through integration science. Lancet 398, 2217–2220 (2021). PubMed DOI
Piaggio, D. et al. A framework for designing medical devices resilient to low-resource settings. Glob. Health 17, 64 (2021). DOI
Karopadi, A. N., Mason, G., Rettore, E. & Ronco, C. Cost of peritoneal dialysis and haemodialysis across the world. Nephrol. Dial. Transpl. 28, 2553–2569 (2013). DOI
Mendu, M. L. et al. Expanding utilization of home dialysis: an action agenda from the first international home dialysis roundtable. Kidney Med. 3, 635–643 (2021). PubMed DOI PMC
Good Medical Council. Good Medical Practice, https://www.gmc-uk.org/ethical-guidance/ethical-guidance-for-doctors/good-medical-practice (2019).
Vanholder, R., Conway, P. T., Gallego, D., Scheres, E. & Wieringa, F. The European Kidney Health Alliance (EKHA) and the Decade of the Kidney™. Nephrol. Dial. Transpl. 38, 1113–1122 (2023). DOI
EUPATI. https://eupati.eu (2023).
Abdel-Kader, K., Greer, R. C., Boulware, L. E. & Unruh, M. L. Primary care physicians’ familiarity, beliefs, and perceived barriers to practice guidelines in non-diabetic CKD: a survey study. BMC Nephrol. 15, 64 (2014). PubMed DOI PMC
Lusignan, S. et al. Audit-based education lowers systolic blood pressure in chronic kidney disease: the Quality Improvement in CKD (QICKD) trial results. Kidney Int. 84, 609–620 (2013). PubMed DOI
Bashshur, R. L. On the definition and evaluation of telemedicine. Telemed. J. 1, 19–30 (1995). PubMed DOI
Parker, J. C. Cherry picking in ESRD: an ethical challenge in the era of pay for performance. Semin. Dialysis 24, 5–8 (2011). DOI
Singer, P., McKie, J., Kuhse, H. & Richardson, J. Double jeopardy and the use of QALYs in health care allocation. J. Med. Ethics 21, 144–150 (1995). PubMed DOI PMC
Amaral, S. et al. Association between dialysis facility ownership and access to the waiting list and transplant in pediatric patients with end-stage kidney disease in the US. JAMA 328, 451–459 (2022). PubMed DOI PMC
Calderon, J. L. et al. Improving diabetes health literacy by animation. Diabetes Educ. 40, 361–372 (2014). 2014. PubMed DOI PMC
Koh, H. K., Brach, C., Harris, L. M. & Parchman, M. L. A proposed ‘health literate care model’ would constitute a systems approach to improving patients’ engagement in care. Health Aff. 32, 357–367 (2013). DOI
Jukkala, A., Deupree, J. P. & Graham, S. Knowledge of limited health literacy at an academic health center. J. Contin. Educ. Nurs. 40, 298–302 (2009). quiz 3-4, 36. PubMed DOI
Karuranga, S., Sorensen, K., Coleman, C. & Mahmud, A. J. Health literacy competencies for European health care personnel. Health Lit. Res. Pract. 1, e247–e256 (2017). PubMed PMC
Elwyn, G. et al. Shared decision making: a model for clinical practice. J. Gen. Intern. Med. 27, 1361–1367 (2012). PubMed DOI PMC
Murgic, L., Hebert, P. C., Sovic, S. & Pavlekovic, G. Paternalism and autonomy: views of patients and providers in a transitional (post-communist) country. BMC Med. Ethics 16, 65 (2015). PubMed DOI PMC
Joosten, E. A. et al. Systematic review of the effects of shared decision-making on patient satisfaction, treatment adherence and health status. Psychother. Psychosom. 77, 219–226 (2008). PubMed DOI
Rosner, M. H., Husain-Syed, F., Reis, T., Ronco, C. & Vanholder, R. Uremic encephalopathy. Kidney Int. 101, 227–241 (2022). PubMed DOI