Metal-organic frameworks (MOFs) are attracting increasing attention as adsorbents of contaminants of emerging concern that are difficult to remove by conventional processes. This paper examines how functional groups covering the pore walls of phosphinate-based MOFs affect the adsorption of specific pharmaceutical pollutants (diclofenac, cephalexin, and sulfamethoxazole) and their hydrolytic stability. New structures, isoreticular to the phosphinate MOF ICR-7, are presented. The phenyl ring facing the pore wall of the presented MOFs is modified with dimethylamino groups (ICR-8) and ethyl carboxylate groups (ICR-14). These functionalized MOFs were obtained from two newly synthesized phosphinate linkers containing the respective functional groups. The presence of additional functional groups resulted in higher affinity toward the tested pollutants compared to ICR-7 or activated carbon. However, this modification also comes with a reduced adsorption capacity. Importantly, the introduction of the functional groups enhanced the hydrolytic stability of the MOFs.

Department of Chemical Physics and Optics Faculty of Mathematics and Physics Charles University Ke Karlovu 3 Prague 121 16 Czech Republic

Department of Environmental Chemistry and Technology Faculty of Environment Jan Evangelista Purkyně University in Ústí nad Labem Pasteurova 3632 15 Ústí nad Labem 400 96 Czech Republic

Department of Inorganic Chemistry Faculty of Science Charles University Hlavova 2030 Prague 128 40 Czech Republic

Institute of Inorganic Chemistry of the Czech Academy of Sciences Husinec Řež 1001 Řež 250 68 Czech Republic

Institute of Physics of the Czech Academy of Sciences Na Slovance 1999 2 Prague 182 21 Czech Republic

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Linker-Functionalized Phosphinate Metal-Organic Frameworks: Adsorbents for the Removal of Emerging Pollutants