Real-world evaluation of UK high hyperdiploidy profile using a large cohort of patients provided by HARMONY data platform
Language English Country Great Britain, England Media print-electronic
Document type Research Support, Non-U.S. Gov't, Letter
Grant support
9609
Cancer Research UK - United Kingdom
PubMed
37773265
PubMed Central
PMC10681889
DOI
10.1038/s41375-023-02046-0
PII: 10.1038/s41375-023-02046-0
Knihovny.cz E-resources
- MeSH
- Aneuploidy * MeSH
- Chromosome Aberrations * MeSH
- Humans MeSH
- Check Tag
- Humans MeSH
- Publication type
- Letter MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- United Kingdom MeSH
Aghia Sophia Children's Hospital Athens Greece
Department of Haematology Great Ormond Street Hospital London UK
Department of Hematology and Stem Cell Transplantation University Hospital Essen Essen Germany
Department of Hematology Erasmus Medical Center Rotterdam Netherlands
Department of Paediatric Haematology and Oncology Hanover Germany
Fondazione GIMEMA Franco Mandelli onlus Rome Italy
Institute for Biomedical Research of Salamanca Salamanca Spain
UCL Cancer Institute London UK
See more in PubMed
Moorman AV, Ensor HM, Richards SM, Chilton L, Schwab C, Kinsey SE, et al. Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial. Lancet Oncol. 2010;11:429–38. doi: 10.1016/S1470-2045(10)70066-8. PubMed DOI
Malard F, Mohty M. Acute lymphoblastic leukaemia. Lancet. 2020;395:1146–62. doi: 10.1016/S0140-6736(19)33018-1. PubMed DOI
Paulsson K, Johansson B. High hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2009;48:637–60. doi: 10.1002/gcc.20671. PubMed DOI
Teachey DT, Pui CH. Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia. Lancet Oncol. 2019;20:e142–e54. doi: 10.1016/S1470-2045(19)30031-2. PubMed DOI PMC
Heerema NA, Sather HN, Sensel MG, Zhang T, Hutchinson RJ, Nachman JB, et al. Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes) J Clin Oncol. 2000;18:1876–87. doi: 10.1200/JCO.2000.18.9.1876. PubMed DOI
Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, et al. Treating childhood acute lymphoblastic leukemia without cranial irradiation. N. Engl J Med. 2009;360:2730–41. doi: 10.1056/NEJMoa0900386. PubMed DOI PMC
Irving JA, Enshaei A, Parker CA, Sutton R, Kuiper RP, Erhorn A, et al. Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia. Blood. 2016;128:911–22. doi: 10.1182/blood-2016-03-704973. PubMed DOI PMC
Enshaei A, Vora A, Harrison CJ, Moppett J, Moorman AV. Defining low-risk high hyperdiploidy in patients with paediatric acute lymphoblastic leukaemia: a retrospective analysis of data from the UKALL97/99 and UKALL2003 clinical trials. Lancet Haematol. 2021;8:e828–39. doi: 10.1016/S2352-3026(21)00304-5. PubMed DOI PMC
Moorman AV, Antony G, Wade R, Butler ER, Enshaei A, Harrison CJ, et al. Time to cure for childhood and young adult acute lymphoblastic leukemia is independent of early risk factors: long-term follow-up of the UKALL2003 Trial. J Clin Oncol. 2022;40:4228–39. doi: 10.1200/JCO.22.00245. PubMed DOI
Team RC. R: A language and environment for statistical computing. 2018.
O’Connor D, Enshaei A, Bartram J, Hancock J, Harrison CJ, Hough R, et al. Genotype-specific minimal residual disease interpretation improves stratification in pediatric acute lymphoblastic leukemia. J Clin Oncol. 2018;36:34–43. doi: 10.1200/JCO.2017.74.0449. PubMed DOI PMC
Haas OA, Borkhardt A. Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children. Leukemia. 2022;36:2769–83. doi: 10.1038/s41375-022-01720-z. PubMed DOI PMC
