Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization
Jazyk angličtina Země Spojené státy americké Médium electronic
Typ dokumentu multicentrická studie, časopisecké články, práce podpořená grantem
PubMed
37906196
PubMed Central
PMC10618839
DOI
10.1001/jamanetworkopen.2023.39793
PII: 2811145
Knihovny.cz E-zdroje
- MeSH
- infekce chirurgické rány prevence a kontrola MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mastektomie MeSH
- nádory prsu * komplikace MeSH
- senioři MeSH
- stafylokokové infekce * prevence a kontrola MeSH
- Staphylococcus aureus MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
IMPORTANCE: Staphylococcus aureus surgical site infections (SSIs) and bloodstream infections (BSIs) are important complications of surgical procedures for which prevention remains suboptimal. Contemporary data on the incidence of and etiologic factors for these infections are needed to support the development of improved preventive strategies. OBJECTIVES: To assess the occurrence of postoperative S aureus SSIs and BSIs and quantify its association with patient-related and contextual factors. DESIGN, SETTING, AND PARTICIPANTS: This multicenter cohort study assessed surgical patients at 33 hospitals in 10 European countries who were recruited between December 16, 2016, and September 30, 2019 (follow-up through December 30, 2019). Enrolled patients were actively followed up for up to 90 days after surgery to assess the occurrence of S aureus SSIs and BSIs. Data analysis was performed between November 20, 2020, and April 21, 2022. All patients were 18 years or older and had undergone 11 different types of surgical procedures. They were screened for S aureus colonization in the nose, throat, and perineum within 30 days before surgery (source population). Both S aureus carriers and noncarriers were subsequently enrolled in a 2:1 ratio. EXPOSURE: Preoperative S aureus colonization. MAIN OUTCOMES AND MEASURES: The main outcome was cumulative incidence of S aureus SSIs and BSIs estimated for the source population, using weighted incidence calculation. The independent association of candidate variables was estimated using multivariable Cox proportional hazards regression models. RESULTS: In total, 5004 patients (median [IQR] age, 66 [56-72] years; 2510 [50.2%] female) were enrolled in the study cohort; 3369 (67.3%) were S aureus carriers. One hundred patients developed S aureus SSIs or BSIs within 90 days after surgery. The weighted cumulative incidence of S aureus SSIs or BSIs was 2.55% (95% CI, 2.05%-3.12%) for carriers and 0.52% (95% CI, 0.22%-0.91%) for noncarriers. Preoperative S aureus colonization (adjusted hazard ratio [AHR], 4.38; 95% CI, 2.19-8.76), having nonremovable implants (AHR, 2.00; 95% CI, 1.15-3.49), undergoing mastectomy (AHR, 5.13; 95% CI, 1.87-14.08) or neurosurgery (AHR, 2.47; 95% CI, 1.09-5.61) (compared with orthopedic surgery), and body mass index (AHR, 1.05; 95% CI, 1.01-1.08 per unit increase) were independently associated with S aureus SSIs and BSIs. CONCLUSIONS AND RELEVANCE: In this cohort study of surgical patients, S aureus carriage was associated with an increased risk of developing S aureus SSIs and BSIs. Both modifiable and nonmodifiable etiologic factors were associated with this risk and should be addressed in those at increased S aureus SSI and BSI risk.
AstraZeneca Plc Gaithersburg Maryland
AZ Sint Lucas Ziekenhuis Gent Campus Volkskliniek Gent Belgium
Azienda Ospedaliera Universitaria Ospedali Riuniti Ancona Italy
Central Military University Emergency Hospital Dr Carol Davila Bucharest Romania
Centre Hospitalier Universitaire de Limoges Limoges France
CIBERINFEC Instituto de Salud Carlos 3 Madrid Spain
Clinical Centre of Kragujevac Kragujevac Serbia
Clinical Centre of Serbia Belgrade Serbia
Department of Surgery Amphia Hospital Breda North Brabant the Netherlands
Department of Surgery Wilhelmina Ziekenhuis Assen Assen Drenthe the Netherlands
Elias Emergency University Hospital Bucharest Romania
Heilig Hart Hospital Lier Belgium
Hospital Brescia University of Brescia Brescia Italy
Hospital del Mar IMIM UPF Barcelona Spain
Hospital Universitario de Asturias Asturia Spain
Hospital Universitario de Bellvitge Barcelona Spain
Hospital Universitario Reina Sofía IMIBIC Cordoba Spain
Hospital Universitario Virgen Macarena Seville Spain
Institute for Orthopedic Surgery Banjica Belgrade Serbia
Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca Romania
Microbial Sciences R and D BioPharmaceuticals AstraZeneca Plc Gaithersburg Maryland
Motol University Hospital Prague Czechia
North Estonia Medical Centre Tallinn Estonia
ow with Gilead Sciences Inc Foster City California
Prof Dr C C Iliescu Institute for Emergency Cardiovascular Diseases Bucharest Romania
South Tees Hospitals NHS Foundation Trust Middlesbrough England United Kingdom
St Anne's University Hospital Brno Czechia
Tartu University Hospital Tartu Estonia
Timisoara County Hospital Timisoara Romania
University Hospital Hradec Králové Hradec Králové Czechia
University Hospital Ostrava Ostrava Poruba Czechia
University Hospitals of Derby and Burton NHS Foundation Trust Derby England United Kingdom
University Hospitals Sussex NHS Foundation Trust Brighton United Kingdom
University Medical Center Utrecht Utrecht University Utrecht the Netherlands
UOC Anestesia e Rianimazione Ospedale Infermi Rimini Italy
York and Scarborough Teaching Hospitals NHS Foundation Trust York England United Kingdom
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